PMC:7589163 / 9438-10434 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T65","span":{"begin":109,"end":113},"obj":"Body_part"},{"id":"T66","span":{"begin":189,"end":193},"obj":"Body_part"},{"id":"T67","span":{"begin":266,"end":274},"obj":"Body_part"},{"id":"T68","span":{"begin":407,"end":412},"obj":"Body_part"},{"id":"T69","span":{"begin":434,"end":458},"obj":"Body_part"},{"id":"T70","span":{"begin":453,"end":458},"obj":"Body_part"},{"id":"T71","span":{"begin":654,"end":658},"obj":"Body_part"},{"id":"T72","span":{"begin":718,"end":722},"obj":"Body_part"},{"id":"T73","span":{"begin":773,"end":791},"obj":"Body_part"},{"id":"T74","span":{"begin":807,"end":811},"obj":"Body_part"},{"id":"T75","span":{"begin":944,"end":948},"obj":"Body_part"}],"attributes":[{"id":"A65","pred":"fma_id","subj":"T65","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A66","pred":"fma_id","subj":"T66","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A67","pred":"fma_id","subj":"T67","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A69","pred":"fma_id","subj":"T69","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A70","pred":"fma_id","subj":"T70","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A71","pred":"fma_id","subj":"T71","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A72","pred":"fma_id","subj":"T72","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A73","pred":"fma_id","subj":"T73","obj":"http://purl.org/sig/ont/fma/fma0326969"},{"id":"A74","pred":"fma_id","subj":"T74","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A75","pred":"fma_id","subj":"T75","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Vitamin A also supports adaptive immunity. Indeed, retinoids represents physiological modulators of normal B cell growth and differentiation, thus vitamin A deficiency negatively affects B cell function [18]. Furthermore, animal studies have shown impairment in the antibody response due to vitamin A deficiency [19]. The production of antibodies may be enhanced by the influence of vitamin A on T helper 2 cells development [22] and antigen-presenting cells [15,23]. In addition, retinoids induce the differentiation of Tregs and maintain both the stability of Tregs and their immunoregulatory function [24]. Indeed, retinoids play fundamental roles in cell-mediated immunity, representing an important cofactor in T cell activation [25] and influencing the expression of membrane receptors that mediate T-cell signalling [17]. Vitamin A supplementation trials conducted in paediatric populations have shown the potential effect to increase T-cell, particularly of the CD4 subpopulation [15,26]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T36","span":{"begin":147,"end":167},"obj":"Disease"},{"id":"T37","span":{"begin":291,"end":311},"obj":"Disease"}],"attributes":[{"id":"A36","pred":"mondo_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/MONDO_0007016"},{"id":"A37","pred":"mondo_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/MONDO_0007016"}],"text":"Vitamin A also supports adaptive immunity. Indeed, retinoids represents physiological modulators of normal B cell growth and differentiation, thus vitamin A deficiency negatively affects B cell function [18]. Furthermore, animal studies have shown impairment in the antibody response due to vitamin A deficiency [19]. The production of antibodies may be enhanced by the influence of vitamin A on T helper 2 cells development [22] and antigen-presenting cells [15,23]. In addition, retinoids induce the differentiation of Tregs and maintain both the stability of Tregs and their immunoregulatory function [24]. Indeed, retinoids play fundamental roles in cell-mediated immunity, representing an important cofactor in T cell activation [25] and influencing the expression of membrane receptors that mediate T-cell signalling [17]. Vitamin A supplementation trials conducted in paediatric populations have shown the potential effect to increase T-cell, particularly of the CD4 subpopulation [15,26]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T98","span":{"begin":8,"end":9},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T99","span":{"begin":107,"end":113},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T100","span":{"begin":155,"end":156},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T101","span":{"begin":187,"end":193},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T102","span":{"begin":204,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0050510"},{"id":"T103","span":{"begin":222,"end":228},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T104","span":{"begin":299,"end":300},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T105","span":{"begin":391,"end":392},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T106","span":{"begin":407,"end":412},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T107","span":{"begin":426,"end":428},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T108","span":{"begin":453,"end":458},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T109","span":{"begin":521,"end":526},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T110","span":{"begin":562,"end":567},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T111","span":{"begin":654,"end":658},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T112","span":{"begin":716,"end":722},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T113","span":{"begin":723,"end":733},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T114","span":{"begin":773,"end":781},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T115","span":{"begin":805,"end":811},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T116","span":{"begin":812,"end":822},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T117","span":{"begin":837,"end":838},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T118","span":{"begin":942,"end":948},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T119","span":{"begin":970,"end":973},"obj":"http://purl.obolibrary.org/obo/PR_000001004"}],"text":"Vitamin A also supports adaptive immunity. Indeed, retinoids represents physiological modulators of normal B cell growth and differentiation, thus vitamin A deficiency negatively affects B cell function [18]. Furthermore, animal studies have shown impairment in the antibody response due to vitamin A deficiency [19]. The production of antibodies may be enhanced by the influence of vitamin A on T helper 2 cells development [22] and antigen-presenting cells [15,23]. In addition, retinoids induce the differentiation of Tregs and maintain both the stability of Tregs and their immunoregulatory function [24]. Indeed, retinoids play fundamental roles in cell-mediated immunity, representing an important cofactor in T cell activation [25] and influencing the expression of membrane receptors that mediate T-cell signalling [17]. Vitamin A supplementation trials conducted in paediatric populations have shown the potential effect to increase T-cell, particularly of the CD4 subpopulation [15,26]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T113","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"T114","span":{"begin":0,"end":7},"obj":"Chemical"},{"id":"T115","span":{"begin":51,"end":60},"obj":"Chemical"},{"id":"T116","span":{"begin":147,"end":156},"obj":"Chemical"},{"id":"T117","span":{"begin":147,"end":154},"obj":"Chemical"},{"id":"T118","span":{"begin":291,"end":300},"obj":"Chemical"},{"id":"T119","span":{"begin":291,"end":298},"obj":"Chemical"},{"id":"T120","span":{"begin":383,"end":392},"obj":"Chemical"},{"id":"T121","span":{"begin":383,"end":390},"obj":"Chemical"},{"id":"T122","span":{"begin":434,"end":441},"obj":"Chemical"},{"id":"T123","span":{"begin":481,"end":490},"obj":"Chemical"},{"id":"T124","span":{"begin":618,"end":627},"obj":"Chemical"},{"id":"T125","span":{"begin":704,"end":712},"obj":"Chemical"},{"id":"T126","span":{"begin":829,"end":838},"obj":"Chemical"},{"id":"T127","span":{"begin":829,"end":836},"obj":"Chemical"}],"attributes":[{"id":"A113","pred":"chebi_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/CHEBI_17336"},{"id":"A114","pred":"chebi_id","subj":"T114","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A115","pred":"chebi_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/CHEBI_26537"},{"id":"A116","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_12777"},{"id":"A117","pred":"chebi_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A118","pred":"chebi_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/CHEBI_12777"},{"id":"A119","pred":"chebi_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A120","pred":"chebi_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/CHEBI_12777"},{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_26537"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_26537"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_23357"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_17336"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"}],"text":"Vitamin A also supports adaptive immunity. Indeed, retinoids represents physiological modulators of normal B cell growth and differentiation, thus vitamin A deficiency negatively affects B cell function [18]. Furthermore, animal studies have shown impairment in the antibody response due to vitamin A deficiency [19]. The production of antibodies may be enhanced by the influence of vitamin A on T helper 2 cells development [22] and antigen-presenting cells [15,23]. In addition, retinoids induce the differentiation of Tregs and maintain both the stability of Tregs and their immunoregulatory function [24]. Indeed, retinoids play fundamental roles in cell-mediated immunity, representing an important cofactor in T cell activation [25] and influencing the expression of membrane receptors that mediate T-cell signalling [17]. Vitamin A supplementation trials conducted in paediatric populations have shown the potential effect to increase T-cell, particularly of the CD4 subpopulation [15,26]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T32","span":{"begin":109,"end":120},"obj":"http://purl.obolibrary.org/obo/GO_0016049"},{"id":"T33","span":{"begin":114,"end":120},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T34","span":{"begin":396,"end":424},"obj":"http://purl.obolibrary.org/obo/GO_0045064"},{"id":"T35","span":{"begin":654,"end":676},"obj":"http://purl.obolibrary.org/obo/GO_0002456"},{"id":"T36","span":{"begin":654,"end":676},"obj":"http://purl.obolibrary.org/obo/GO_0002449"},{"id":"T37","span":{"begin":716,"end":733},"obj":"http://purl.obolibrary.org/obo/GO_0042110"},{"id":"T38","span":{"begin":718,"end":733},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T39","span":{"begin":812,"end":822},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"Vitamin A also supports adaptive immunity. Indeed, retinoids represents physiological modulators of normal B cell growth and differentiation, thus vitamin A deficiency negatively affects B cell function [18]. Furthermore, animal studies have shown impairment in the antibody response due to vitamin A deficiency [19]. The production of antibodies may be enhanced by the influence of vitamin A on T helper 2 cells development [22] and antigen-presenting cells [15,23]. In addition, retinoids induce the differentiation of Tregs and maintain both the stability of Tregs and their immunoregulatory function [24]. Indeed, retinoids play fundamental roles in cell-mediated immunity, representing an important cofactor in T cell activation [25] and influencing the expression of membrane receptors that mediate T-cell signalling [17]. Vitamin A supplementation trials conducted in paediatric populations have shown the potential effect to increase T-cell, particularly of the CD4 subpopulation [15,26]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T8","span":{"begin":147,"end":167},"obj":"Phenotype"},{"id":"T9","span":{"begin":291,"end":311},"obj":"Phenotype"}],"attributes":[{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0004905"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0004905"}],"text":"Vitamin A also supports adaptive immunity. Indeed, retinoids represents physiological modulators of normal B cell growth and differentiation, thus vitamin A deficiency negatively affects B cell function [18]. Furthermore, animal studies have shown impairment in the antibody response due to vitamin A deficiency [19]. The production of antibodies may be enhanced by the influence of vitamin A on T helper 2 cells development [22] and antigen-presenting cells [15,23]. In addition, retinoids induce the differentiation of Tregs and maintain both the stability of Tregs and their immunoregulatory function [24]. Indeed, retinoids play fundamental roles in cell-mediated immunity, representing an important cofactor in T cell activation [25] and influencing the expression of membrane receptors that mediate T-cell signalling [17]. Vitamin A supplementation trials conducted in paediatric populations have shown the potential effect to increase T-cell, particularly of the CD4 subpopulation [15,26]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T68","span":{"begin":0,"end":42},"obj":"Sentence"},{"id":"T69","span":{"begin":43,"end":208},"obj":"Sentence"},{"id":"T70","span":{"begin":209,"end":317},"obj":"Sentence"},{"id":"T71","span":{"begin":318,"end":467},"obj":"Sentence"},{"id":"T72","span":{"begin":468,"end":609},"obj":"Sentence"},{"id":"T73","span":{"begin":610,"end":828},"obj":"Sentence"},{"id":"T74","span":{"begin":829,"end":996},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Vitamin A also supports adaptive immunity. Indeed, retinoids represents physiological modulators of normal B cell growth and differentiation, thus vitamin A deficiency negatively affects B cell function [18]. Furthermore, animal studies have shown impairment in the antibody response due to vitamin A deficiency [19]. The production of antibodies may be enhanced by the influence of vitamin A on T helper 2 cells development [22] and antigen-presenting cells [15,23]. In addition, retinoids induce the differentiation of Tregs and maintain both the stability of Tregs and their immunoregulatory function [24]. Indeed, retinoids play fundamental roles in cell-mediated immunity, representing an important cofactor in T cell activation [25] and influencing the expression of membrane receptors that mediate T-cell signalling [17]. Vitamin A supplementation trials conducted in paediatric populations have shown the potential effect to increase T-cell, particularly of the CD4 subpopulation [15,26]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"175","span":{"begin":970,"end":973},"obj":"Gene"},{"id":"176","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"177","span":{"begin":51,"end":60},"obj":"Chemical"},{"id":"178","span":{"begin":383,"end":392},"obj":"Chemical"},{"id":"179","span":{"begin":481,"end":490},"obj":"Chemical"},{"id":"180","span":{"begin":521,"end":526},"obj":"Chemical"},{"id":"181","span":{"begin":562,"end":567},"obj":"Chemical"},{"id":"182","span":{"begin":618,"end":627},"obj":"Chemical"},{"id":"183","span":{"begin":829,"end":838},"obj":"Chemical"},{"id":"184","span":{"begin":147,"end":167},"obj":"Disease"},{"id":"185","span":{"begin":299,"end":311},"obj":"Disease"}],"attributes":[{"id":"A175","pred":"tao:has_database_id","subj":"175","obj":"Gene:920"},{"id":"A176","pred":"tao:has_database_id","subj":"176","obj":"MESH:D014801"},{"id":"A177","pred":"tao:has_database_id","subj":"177","obj":"MESH:D012176"},{"id":"A178","pred":"tao:has_database_id","subj":"178","obj":"MESH:D014801"},{"id":"A179","pred":"tao:has_database_id","subj":"179","obj":"MESH:D012176"},{"id":"A182","pred":"tao:has_database_id","subj":"182","obj":"MESH:D012176"},{"id":"A183","pred":"tao:has_database_id","subj":"183","obj":"MESH:D014801"},{"id":"A184","pred":"tao:has_database_id","subj":"184","obj":"MESH:D014802"},{"id":"A185","pred":"tao:has_database_id","subj":"185","obj":"MESH:D007153"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Vitamin A also supports adaptive immunity. Indeed, retinoids represents physiological modulators of normal B cell growth and differentiation, thus vitamin A deficiency negatively affects B cell function [18]. Furthermore, animal studies have shown impairment in the antibody response due to vitamin A deficiency [19]. The production of antibodies may be enhanced by the influence of vitamin A on T helper 2 cells development [22] and antigen-presenting cells [15,23]. In addition, retinoids induce the differentiation of Tregs and maintain both the stability of Tregs and their immunoregulatory function [24]. Indeed, retinoids play fundamental roles in cell-mediated immunity, representing an important cofactor in T cell activation [25] and influencing the expression of membrane receptors that mediate T-cell signalling [17]. Vitamin A supplementation trials conducted in paediatric populations have shown the potential effect to increase T-cell, particularly of the CD4 subpopulation [15,26]."}