PMC:7589163 / 61510-63263 JSONTXT

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    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T305","span":{"begin":249,"end":266},"obj":"Body_part"}],"attributes":[{"id":"A305","pred":"fma_id","subj":"T305","obj":"http://purl.org/sig/ont/fma/fma265130"}],"text":"7.3. Zinc Supplementation in Preventing Viral Infections\nFrom the early 2000s, various studies were conducted, mainly in children from lower socio-economic settings, to establish whether daily or weekly zinc supplementation could help in preventing respiratory tract infections (Table 9) [269,270,271,272,273,274,275,276,277,278,279,280,281].\nDifferent studies reported a reduced incidence of respiratory infections in the zinc receiving group [269,271,272,273,280]. In 2007, Sazawal et al. reported a slight reduction in the relative risk of all-cause mortality in children supplemented with zinc in Zanzibar [277]. Other studies found instead that zinc supplementation had no significant effect on the frequency of respiratory infections [274,275,276,278,279,281]. Some of these trials used a lower daily dose of zinc, which might be one of the reasons why the supplementation was less effective; however, both negative and positive results were reported with different zinc dosages, from 5 up to 30 mg/day.\nOverall, different reviews and meta-analysis confirmed the efficacy of zinc supplementation in preventing respiratory illnesses: Aggarwal et al. reported that zinc supplementation for more than 3 months significantly reduced the frequency and severity of diarrhea and respiratory illnesses [282]; in 2010, Roth et al. found that routine zinc supplementation reduced the incidence of childhood ALRI [283]; in 2011, Yakoob and colleagues described a reduction in diarrhea and pneumonia mortality in children from developing countries who received zinc supplementation for over 3 months [284]; a 2016 systematic review also reported a statistically significant lower incidence of pneumonia (−13%) in children receiving zinc supplementation [285]."}

    LitCovid-PD-UBERON

    {"project":"LitCovid-PD-UBERON","denotations":[{"id":"T115","span":{"begin":249,"end":266},"obj":"Body_part"}],"attributes":[{"id":"A115","pred":"uberon_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"}],"text":"7.3. Zinc Supplementation in Preventing Viral Infections\nFrom the early 2000s, various studies were conducted, mainly in children from lower socio-economic settings, to establish whether daily or weekly zinc supplementation could help in preventing respiratory tract infections (Table 9) [269,270,271,272,273,274,275,276,277,278,279,280,281].\nDifferent studies reported a reduced incidence of respiratory infections in the zinc receiving group [269,271,272,273,280]. In 2007, Sazawal et al. reported a slight reduction in the relative risk of all-cause mortality in children supplemented with zinc in Zanzibar [277]. Other studies found instead that zinc supplementation had no significant effect on the frequency of respiratory infections [274,275,276,278,279,281]. Some of these trials used a lower daily dose of zinc, which might be one of the reasons why the supplementation was less effective; however, both negative and positive results were reported with different zinc dosages, from 5 up to 30 mg/day.\nOverall, different reviews and meta-analysis confirmed the efficacy of zinc supplementation in preventing respiratory illnesses: Aggarwal et al. reported that zinc supplementation for more than 3 months significantly reduced the frequency and severity of diarrhea and respiratory illnesses [282]; in 2010, Roth et al. found that routine zinc supplementation reduced the incidence of childhood ALRI [283]; in 2011, Yakoob and colleagues described a reduction in diarrhea and pneumonia mortality in children from developing countries who received zinc supplementation for over 3 months [284]; a 2016 systematic review also reported a statistically significant lower incidence of pneumonia (−13%) in children receiving zinc supplementation [285]."}

    LitCovid-PD-MONDO

    {"project":"LitCovid-PD-MONDO","denotations":[{"id":"T232","span":{"begin":249,"end":277},"obj":"Disease"},{"id":"T233","span":{"begin":393,"end":415},"obj":"Disease"},{"id":"T234","span":{"begin":717,"end":739},"obj":"Disease"},{"id":"T235","span":{"begin":1265,"end":1273},"obj":"Disease"},{"id":"T236","span":{"begin":1471,"end":1479},"obj":"Disease"},{"id":"T237","span":{"begin":1484,"end":1493},"obj":"Disease"},{"id":"T238","span":{"begin":1687,"end":1696},"obj":"Disease"}],"attributes":[{"id":"A232","pred":"mondo_id","subj":"T232","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A233","pred":"mondo_id","subj":"T233","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A234","pred":"mondo_id","subj":"T234","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A235","pred":"mondo_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A236","pred":"mondo_id","subj":"T236","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A237","pred":"mondo_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A238","pred":"mondo_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"}],"text":"7.3. Zinc Supplementation in Preventing Viral Infections\nFrom the early 2000s, various studies were conducted, mainly in children from lower socio-economic settings, to establish whether daily or weekly zinc supplementation could help in preventing respiratory tract infections (Table 9) [269,270,271,272,273,274,275,276,277,278,279,280,281].\nDifferent studies reported a reduced incidence of respiratory infections in the zinc receiving group [269,271,272,273,280]. In 2007, Sazawal et al. reported a slight reduction in the relative risk of all-cause mortality in children supplemented with zinc in Zanzibar [277]. Other studies found instead that zinc supplementation had no significant effect on the frequency of respiratory infections [274,275,276,278,279,281]. Some of these trials used a lower daily dose of zinc, which might be one of the reasons why the supplementation was less effective; however, both negative and positive results were reported with different zinc dosages, from 5 up to 30 mg/day.\nOverall, different reviews and meta-analysis confirmed the efficacy of zinc supplementation in preventing respiratory illnesses: Aggarwal et al. reported that zinc supplementation for more than 3 months significantly reduced the frequency and severity of diarrhea and respiratory illnesses [282]; in 2010, Roth et al. found that routine zinc supplementation reduced the incidence of childhood ALRI [283]; in 2011, Yakoob and colleagues described a reduction in diarrhea and pneumonia mortality in children from developing countries who received zinc supplementation for over 3 months [284]; a 2016 systematic review also reported a statistically significant lower incidence of pneumonia (−13%) in children receiving zinc supplementation [285]."}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T595","span":{"begin":370,"end":371},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T596","span":{"begin":500,"end":501},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T597","span":{"begin":793,"end":794},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T598","span":{"begin":1456,"end":1457},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T599","span":{"begin":1601,"end":1602},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T600","span":{"begin":1640,"end":1641},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"7.3. Zinc Supplementation in Preventing Viral Infections\nFrom the early 2000s, various studies were conducted, mainly in children from lower socio-economic settings, to establish whether daily or weekly zinc supplementation could help in preventing respiratory tract infections (Table 9) [269,270,271,272,273,274,275,276,277,278,279,280,281].\nDifferent studies reported a reduced incidence of respiratory infections in the zinc receiving group [269,271,272,273,280]. In 2007, Sazawal et al. reported a slight reduction in the relative risk of all-cause mortality in children supplemented with zinc in Zanzibar [277]. Other studies found instead that zinc supplementation had no significant effect on the frequency of respiratory infections [274,275,276,278,279,281]. Some of these trials used a lower daily dose of zinc, which might be one of the reasons why the supplementation was less effective; however, both negative and positive results were reported with different zinc dosages, from 5 up to 30 mg/day.\nOverall, different reviews and meta-analysis confirmed the efficacy of zinc supplementation in preventing respiratory illnesses: Aggarwal et al. reported that zinc supplementation for more than 3 months significantly reduced the frequency and severity of diarrhea and respiratory illnesses [282]; in 2010, Roth et al. found that routine zinc supplementation reduced the incidence of childhood ALRI [283]; in 2011, Yakoob and colleagues described a reduction in diarrhea and pneumonia mortality in children from developing countries who received zinc supplementation for over 3 months [284]; a 2016 systematic review also reported a statistically significant lower incidence of pneumonia (−13%) in children receiving zinc supplementation [285]."}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T72145","span":{"begin":203,"end":207},"obj":"Chemical"},{"id":"T88124","span":{"begin":423,"end":427},"obj":"Chemical"},{"id":"T96891","span":{"begin":438,"end":443},"obj":"Chemical"},{"id":"T80510","span":{"begin":593,"end":597},"obj":"Chemical"},{"id":"T62359","span":{"begin":650,"end":654},"obj":"Chemical"},{"id":"T86995","span":{"begin":815,"end":819},"obj":"Chemical"},{"id":"T205","span":{"begin":972,"end":976},"obj":"Chemical"},{"id":"T61771","span":{"begin":1081,"end":1085},"obj":"Chemical"},{"id":"T209","span":{"begin":1169,"end":1173},"obj":"Chemical"},{"id":"T70946","span":{"begin":1347,"end":1351},"obj":"Chemical"},{"id":"T52881","span":{"begin":1555,"end":1559},"obj":"Chemical"},{"id":"T39499","span":{"begin":1726,"end":1730},"obj":"Chemical"}],"attributes":[{"id":"A47639","pred":"chebi_id","subj":"T72145","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A64548","pred":"chebi_id","subj":"T72145","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A19715","pred":"chebi_id","subj":"T88124","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A92695","pred":"chebi_id","subj":"T88124","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A69565","pred":"chebi_id","subj":"T96891","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A56282","pred":"chebi_id","subj":"T80510","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A59589","pred":"chebi_id","subj":"T80510","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A32379","pred":"chebi_id","subj":"T62359","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A9767","pred":"chebi_id","subj":"T62359","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A27816","pred":"chebi_id","subj":"T86995","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A89185","pred":"chebi_id","subj":"T86995","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A18753","pred":"chebi_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A53920","pred":"chebi_id","subj":"T205","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A28536","pred":"chebi_id","subj":"T61771","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A1568","pred":"chebi_id","subj":"T61771","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A46673","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A39011","pred":"chebi_id","subj":"T209","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A65045","pred":"chebi_id","subj":"T70946","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A19442","pred":"chebi_id","subj":"T70946","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A57147","pred":"chebi_id","subj":"T52881","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A82785","pred":"chebi_id","subj":"T52881","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A12803","pred":"chebi_id","subj":"T39499","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A39510","pred":"chebi_id","subj":"T39499","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"}],"text":"7.3. Zinc Supplementation in Preventing Viral Infections\nFrom the early 2000s, various studies were conducted, mainly in children from lower socio-economic settings, to establish whether daily or weekly zinc supplementation could help in preventing respiratory tract infections (Table 9) [269,270,271,272,273,274,275,276,277,278,279,280,281].\nDifferent studies reported a reduced incidence of respiratory infections in the zinc receiving group [269,271,272,273,280]. In 2007, Sazawal et al. reported a slight reduction in the relative risk of all-cause mortality in children supplemented with zinc in Zanzibar [277]. Other studies found instead that zinc supplementation had no significant effect on the frequency of respiratory infections [274,275,276,278,279,281]. Some of these trials used a lower daily dose of zinc, which might be one of the reasons why the supplementation was less effective; however, both negative and positive results were reported with different zinc dosages, from 5 up to 30 mg/day.\nOverall, different reviews and meta-analysis confirmed the efficacy of zinc supplementation in preventing respiratory illnesses: Aggarwal et al. reported that zinc supplementation for more than 3 months significantly reduced the frequency and severity of diarrhea and respiratory illnesses [282]; in 2010, Roth et al. found that routine zinc supplementation reduced the incidence of childhood ALRI [283]; in 2011, Yakoob and colleagues described a reduction in diarrhea and pneumonia mortality in children from developing countries who received zinc supplementation for over 3 months [284]; a 2016 systematic review also reported a statistically significant lower incidence of pneumonia (−13%) in children receiving zinc supplementation [285]."}

    LitCovid-PD-GO-BP

    {"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T155","span":{"begin":40,"end":56},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"7.3. Zinc Supplementation in Preventing Viral Infections\nFrom the early 2000s, various studies were conducted, mainly in children from lower socio-economic settings, to establish whether daily or weekly zinc supplementation could help in preventing respiratory tract infections (Table 9) [269,270,271,272,273,274,275,276,277,278,279,280,281].\nDifferent studies reported a reduced incidence of respiratory infections in the zinc receiving group [269,271,272,273,280]. In 2007, Sazawal et al. reported a slight reduction in the relative risk of all-cause mortality in children supplemented with zinc in Zanzibar [277]. Other studies found instead that zinc supplementation had no significant effect on the frequency of respiratory infections [274,275,276,278,279,281]. Some of these trials used a lower daily dose of zinc, which might be one of the reasons why the supplementation was less effective; however, both negative and positive results were reported with different zinc dosages, from 5 up to 30 mg/day.\nOverall, different reviews and meta-analysis confirmed the efficacy of zinc supplementation in preventing respiratory illnesses: Aggarwal et al. reported that zinc supplementation for more than 3 months significantly reduced the frequency and severity of diarrhea and respiratory illnesses [282]; in 2010, Roth et al. found that routine zinc supplementation reduced the incidence of childhood ALRI [283]; in 2011, Yakoob and colleagues described a reduction in diarrhea and pneumonia mortality in children from developing countries who received zinc supplementation for over 3 months [284]; a 2016 systematic review also reported a statistically significant lower incidence of pneumonia (−13%) in children receiving zinc supplementation [285]."}

    LitCovid-PD-HP

    {"project":"LitCovid-PD-HP","denotations":[{"id":"T116","span":{"begin":249,"end":277},"obj":"Phenotype"},{"id":"T117","span":{"begin":393,"end":415},"obj":"Phenotype"},{"id":"T118","span":{"begin":717,"end":739},"obj":"Phenotype"},{"id":"T119","span":{"begin":1116,"end":1137},"obj":"Phenotype"},{"id":"T120","span":{"begin":1265,"end":1273},"obj":"Phenotype"},{"id":"T121","span":{"begin":1278,"end":1299},"obj":"Phenotype"},{"id":"T122","span":{"begin":1471,"end":1479},"obj":"Phenotype"},{"id":"T123","span":{"begin":1484,"end":1493},"obj":"Phenotype"},{"id":"T124","span":{"begin":1687,"end":1696},"obj":"Phenotype"}],"attributes":[{"id":"A116","pred":"hp_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/HP_0011947"},{"id":"A117","pred":"hp_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/HP_0011947"},{"id":"A118","pred":"hp_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/HP_0011947"},{"id":"A119","pred":"hp_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/HP_0002086"},{"id":"A120","pred":"hp_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A121","pred":"hp_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/HP_0002086"},{"id":"A122","pred":"hp_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/HP_0002014"},{"id":"A123","pred":"hp_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A124","pred":"hp_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"7.3. Zinc Supplementation in Preventing Viral Infections\nFrom the early 2000s, various studies were conducted, mainly in children from lower socio-economic settings, to establish whether daily or weekly zinc supplementation could help in preventing respiratory tract infections (Table 9) [269,270,271,272,273,274,275,276,277,278,279,280,281].\nDifferent studies reported a reduced incidence of respiratory infections in the zinc receiving group [269,271,272,273,280]. In 2007, Sazawal et al. reported a slight reduction in the relative risk of all-cause mortality in children supplemented with zinc in Zanzibar [277]. Other studies found instead that zinc supplementation had no significant effect on the frequency of respiratory infections [274,275,276,278,279,281]. Some of these trials used a lower daily dose of zinc, which might be one of the reasons why the supplementation was less effective; however, both negative and positive results were reported with different zinc dosages, from 5 up to 30 mg/day.\nOverall, different reviews and meta-analysis confirmed the efficacy of zinc supplementation in preventing respiratory illnesses: Aggarwal et al. reported that zinc supplementation for more than 3 months significantly reduced the frequency and severity of diarrhea and respiratory illnesses [282]; in 2010, Roth et al. found that routine zinc supplementation reduced the incidence of childhood ALRI [283]; in 2011, Yakoob and colleagues described a reduction in diarrhea and pneumonia mortality in children from developing countries who received zinc supplementation for over 3 months [284]; a 2016 systematic review also reported a statistically significant lower incidence of pneumonia (−13%) in children receiving zinc supplementation [285]."}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T366","span":{"begin":0,"end":4},"obj":"Sentence"},{"id":"T367","span":{"begin":5,"end":56},"obj":"Sentence"},{"id":"T368","span":{"begin":57,"end":342},"obj":"Sentence"},{"id":"T369","span":{"begin":343,"end":466},"obj":"Sentence"},{"id":"T370","span":{"begin":467,"end":616},"obj":"Sentence"},{"id":"T371","span":{"begin":617,"end":766},"obj":"Sentence"},{"id":"T372","span":{"begin":767,"end":1009},"obj":"Sentence"},{"id":"T373","span":{"begin":1010,"end":1138},"obj":"Sentence"},{"id":"T374","span":{"begin":1139,"end":1753},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"7.3. Zinc Supplementation in Preventing Viral Infections\nFrom the early 2000s, various studies were conducted, mainly in children from lower socio-economic settings, to establish whether daily or weekly zinc supplementation could help in preventing respiratory tract infections (Table 9) [269,270,271,272,273,274,275,276,277,278,279,280,281].\nDifferent studies reported a reduced incidence of respiratory infections in the zinc receiving group [269,271,272,273,280]. In 2007, Sazawal et al. reported a slight reduction in the relative risk of all-cause mortality in children supplemented with zinc in Zanzibar [277]. Other studies found instead that zinc supplementation had no significant effect on the frequency of respiratory infections [274,275,276,278,279,281]. Some of these trials used a lower daily dose of zinc, which might be one of the reasons why the supplementation was less effective; however, both negative and positive results were reported with different zinc dosages, from 5 up to 30 mg/day.\nOverall, different reviews and meta-analysis confirmed the efficacy of zinc supplementation in preventing respiratory illnesses: Aggarwal et al. reported that zinc supplementation for more than 3 months significantly reduced the frequency and severity of diarrhea and respiratory illnesses [282]; in 2010, Roth et al. found that routine zinc supplementation reduced the incidence of childhood ALRI [283]; in 2011, Yakoob and colleagues described a reduction in diarrhea and pneumonia mortality in children from developing countries who received zinc supplementation for over 3 months [284]; a 2016 systematic review also reported a statistically significant lower incidence of pneumonia (−13%) in children receiving zinc supplementation [285]."}

    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"1531","span":{"begin":40,"end":56},"obj":"Disease"},{"id":"1534","span":{"begin":121,"end":129},"obj":"Species"},{"id":"1535","span":{"begin":249,"end":277},"obj":"Disease"},{"id":"1540","span":{"begin":566,"end":574},"obj":"Species"},{"id":"1541","span":{"begin":393,"end":415},"obj":"Disease"},{"id":"1542","span":{"begin":553,"end":562},"obj":"Disease"},{"id":"1543","span":{"begin":717,"end":739},"obj":"Disease"},{"id":"1552","span":{"begin":1507,"end":1515},"obj":"Species"},{"id":"1553","span":{"begin":1707,"end":1715},"obj":"Species"},{"id":"1554","span":{"begin":1116,"end":1137},"obj":"Disease"},{"id":"1555","span":{"begin":1265,"end":1273},"obj":"Disease"},{"id":"1556","span":{"begin":1278,"end":1299},"obj":"Disease"},{"id":"1557","span":{"begin":1471,"end":1479},"obj":"Disease"},{"id":"1558","span":{"begin":1484,"end":1503},"obj":"Disease"},{"id":"1559","span":{"begin":1687,"end":1696},"obj":"Disease"}],"attributes":[{"id":"A1531","pred":"tao:has_database_id","subj":"1531","obj":"MESH:D001102"},{"id":"A1534","pred":"tao:has_database_id","subj":"1534","obj":"Tax:9606"},{"id":"A1535","pred":"tao:has_database_id","subj":"1535","obj":"MESH:D012141"},{"id":"A1540","pred":"tao:has_database_id","subj":"1540","obj":"Tax:9606"},{"id":"A1541","pred":"tao:has_database_id","subj":"1541","obj":"MESH:D012141"},{"id":"A1542","pred":"tao:has_database_id","subj":"1542","obj":"MESH:D003643"},{"id":"A1543","pred":"tao:has_database_id","subj":"1543","obj":"MESH:D012141"},{"id":"A1552","pred":"tao:has_database_id","subj":"1552","obj":"Tax:9606"},{"id":"A1553","pred":"tao:has_database_id","subj":"1553","obj":"Tax:9606"},{"id":"A1554","pred":"tao:has_database_id","subj":"1554","obj":"MESH:D012140"},{"id":"A1555","pred":"tao:has_database_id","subj":"1555","obj":"MESH:D003967"},{"id":"A1556","pred":"tao:has_database_id","subj":"1556","obj":"MESH:D012140"},{"id":"A1557","pred":"tao:has_database_id","subj":"1557","obj":"MESH:D003967"},{"id":"A1558","pred":"tao:has_database_id","subj":"1558","obj":"MESH:D003643"},{"id":"A1559","pred":"tao:has_database_id","subj":"1559","obj":"MESH:D011014"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"7.3. Zinc Supplementation in Preventing Viral Infections\nFrom the early 2000s, various studies were conducted, mainly in children from lower socio-economic settings, to establish whether daily or weekly zinc supplementation could help in preventing respiratory tract infections (Table 9) [269,270,271,272,273,274,275,276,277,278,279,280,281].\nDifferent studies reported a reduced incidence of respiratory infections in the zinc receiving group [269,271,272,273,280]. In 2007, Sazawal et al. reported a slight reduction in the relative risk of all-cause mortality in children supplemented with zinc in Zanzibar [277]. Other studies found instead that zinc supplementation had no significant effect on the frequency of respiratory infections [274,275,276,278,279,281]. Some of these trials used a lower daily dose of zinc, which might be one of the reasons why the supplementation was less effective; however, both negative and positive results were reported with different zinc dosages, from 5 up to 30 mg/day.\nOverall, different reviews and meta-analysis confirmed the efficacy of zinc supplementation in preventing respiratory illnesses: Aggarwal et al. reported that zinc supplementation for more than 3 months significantly reduced the frequency and severity of diarrhea and respiratory illnesses [282]; in 2010, Roth et al. found that routine zinc supplementation reduced the incidence of childhood ALRI [283]; in 2011, Yakoob and colleagues described a reduction in diarrhea and pneumonia mortality in children from developing countries who received zinc supplementation for over 3 months [284]; a 2016 systematic review also reported a statistically significant lower incidence of pneumonia (−13%) in children receiving zinc supplementation [285]."}