PMC:7589163 / 59137-61508
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T302 | 111-124 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T303 | 313-318 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T304 | 1143-1148 | Body_part | denotes | chest | http://purl.org/sig/ont/fma/fma9576 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T112 | 111-124 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T113 | 313-318 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T114 | 1143-1148 | Body_part | denotes | chest | http://purl.obolibrary.org/obo/UBERON_0001443 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T226 | 374-383 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T227 | 1439-1461 | Disease | denotes | respiratory infections | http://purl.obolibrary.org/obo/MONDO_0024355 |
| T228 | 1684-1693 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T229 | 1804-1813 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T230 | 2349-2370 | Disease | denotes | respiratory infection | http://purl.obolibrary.org/obo/MONDO_0024355 |
| T231 | 2361-2370 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T582 | 111-124 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T583 | 299-300 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T584 | 301-305 | http://purl.obolibrary.org/obo/CLO_0001185 | denotes | 2018 |
| T585 | 478-479 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T586 | 1068-1069 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T587 | 1143-1148 | http://www.ebi.ac.uk/efo/EFO_0000965 | denotes | chest |
| T588 | 1287-1288 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T589 | 1502-1503 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T590 | 1574-1575 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T591 | 1756-1757 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T592 | 1868-1869 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T593 | 1935-1936 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T594 | 2169-2170 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T90130 | 88-92 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T62273 | 184-188 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T27748 | 319-323 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T43683 | 518-522 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T62708 | 781-786 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T89061 | 912-916 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T57170 | 1083-1087 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T30936 | 1409-1413 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T84920 | 1537-1541 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T96591 | 1646-1650 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T77804 | 1843-1847 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T33497 | 1894-1898 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T23568 | 2074-2078 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
| T71392 | 2293-2297 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T154 | 38-54 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | Viral Infections |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T109 | 201-222 | Phenotype | denotes | respiratory illnesses | http://purl.obolibrary.org/obo/HP_0002086 |
| T110 | 374-383 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T111 | 571-577 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T112 | 1439-1461 | Phenotype | denotes | respiratory infections | http://purl.obolibrary.org/obo/HP_0011947 |
| T113 | 1804-1813 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T114 | 2115-2134 | Phenotype | denotes | respiratory illness | http://purl.obolibrary.org/obo/HP_0002086 |
| T115 | 2349-2370 | Phenotype | denotes | respiratory infection | http://purl.obolibrary.org/obo/HP_0011947 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T358 | 0-4 | Sentence | denotes | 7.2. |
| T359 | 5-54 | Sentence | denotes | Zinc Supplementation in Treating Viral Infections |
| T360 | 55-295 | Sentence | denotes | Considering the known effects of zinc in regulating the immune system, trials have been conducted to investigate the efficacy of zinc in treating respiratory illnesses (Table 8) [253,254,255,256,257,258,259,260,261,262,263,264,265,266,267]. |
| T361 | 296-625 | Sentence | denotes | In a 2018 study, serum zinc levels were found to be significantly lower among pneumonia pediatric patients admitted to PICU compared with patients admitted to other wards; there was a statistically significant decrease in zinc level in critically ill children complicated by sepsis, mechanically ventilated and fatal cases [252]. |
| T362 | 626-872 | Sentence | denotes | Some studies reported similar duration of hospital stay, time to symptoms resolution, and risk of treatment failure in the intervention and in the control group [254,255,256,258,259,262,264,265], while others described partially positive results. |
| T363 | 873-1355 | Sentence | denotes | Basnet and colleagues [260] found that zinc recepients recovered slightly faster than controls, although the difference was not statistically significant; Sempertegui et al. [263] evidenced that a higher basal zinc concentration was associated with faster resolution of chest indrawing, although there was no difference in time needed to fully recover nor in the risk of treatment failure; Mahalanbis et al. found a reduced duration of ALRI symptoms in boys, but not in girls [253]. |
| T364 | 1356-2000 | Sentence | denotes | Other trials evidenced instead positive results with zinc supplementation in acute respiratory infections: in 2011, Valavi et al. [257] described a faster resolution of symptoms in zinc-supplemented children; in 2012, a lower mortality rate was evidenced in Uganda in children who received zinc supplementation during the acute infection [261]; in 2019, Acevedo-Murillo and colleagues [266] reported a quicker improvement in the clinical status of pneumonia pediatric patients receiving zinc supplementation; in a Thailandese 2019 trial, zinc supplementation was associated with a shorter hospital stay and quicker resolution of symptoms [267]. |
| T365 | 2001-2371 | Sentence | denotes | Overall, the available data does not conclusively assert the efficacy of zinc in treating an existing acute lower respiratory illness in children, as also described in a 2012 meta-analysis from Das and colleagues [268]; more studies are needed to definitively establish if, and at what dose, zinc should be supplemented to children during an acute respiratory infection. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1489 | 38-54 | Disease | denotes | Viral Infections | MESH:D001102 |
| 1491 | 201-222 | Disease | denotes | respiratory illnesses | MESH:D012140 |
| 1500 | 394-402 | Species | denotes | patients | Tax:9606 |
| 1501 | 434-442 | Species | denotes | patients | Tax:9606 |
| 1502 | 547-555 | Species | denotes | children | Tax:9606 |
| 1503 | 1326-1330 | Species | denotes | boys | Tax:9606 |
| 1504 | 1343-1348 | Species | denotes | girls | Tax:9606 |
| 1505 | 374-383 | Disease | denotes | pneumonia | MESH:D011014 |
| 1506 | 532-546 | Disease | denotes | critically ill | MESH:D016638 |
| 1507 | 571-577 | Disease | denotes | sepsis | MESH:D018805 |
| 1515 | 1555-1563 | Species | denotes | children | Tax:9606 |
| 1516 | 1624-1632 | Species | denotes | children | Tax:9606 |
| 1517 | 1824-1832 | Species | denotes | patients | Tax:9606 |
| 1518 | 1433-1461 | Disease | denotes | acute respiratory infections | MESH:D012120 |
| 1519 | 1582-1591 | Disease | denotes | mortality | MESH:D003643 |
| 1520 | 1684-1693 | Disease | denotes | infection | MESH:D007239 |
| 1521 | 1804-1813 | Disease | denotes | pneumonia | MESH:D011014 |
| 1526 | 2138-2146 | Species | denotes | children | Tax:9606 |
| 1527 | 2324-2332 | Species | denotes | children | Tax:9606 |
| 1528 | 2115-2134 | Disease | denotes | respiratory illness | MESH:D012140 |
| 1529 | 2349-2370 | Disease | denotes | respiratory infection | MESH:D012141 |