PMC:7589163 / 44467-45367 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T213","span":{"begin":433,"end":446},"obj":"Body_part"},{"id":"T214","span":{"begin":793,"end":801},"obj":"Body_part"}],"attributes":[{"id":"A213","pred":"fma_id","subj":"T213","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A214","pred":"fma_id","subj":"T214","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"Moreover, a wide variation in the severity of SARS-CoV2 infection’s clinical presentation has been noticed, ranging from absent or minimal symptoms to critical conditions and death. To date, although some risk factors have been identified (age, co-morbidities, etc.), it is not yet completely understood why some patients develop more severe symptoms than others. Considering our knowledge on the role of vitamin D in modulating the immune system and in inhibiting a hyper activation of the inflammatory response, together with data from observational and clinical studies on vitamin D supplementation, various authors have also suggested a potential role of vitamin D in reducing the severity of the disease [183,184,185,186,187]. Vitamin D is especially known for its ability to reduce the “cytokine storm” that contributes to the pathogenesis of various viral infections, including COVID-19 [188]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T84","span":{"begin":433,"end":446},"obj":"Body_part"}],"attributes":[{"id":"A84","pred":"uberon_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"Moreover, a wide variation in the severity of SARS-CoV2 infection’s clinical presentation has been noticed, ranging from absent or minimal symptoms to critical conditions and death. To date, although some risk factors have been identified (age, co-morbidities, etc.), it is not yet completely understood why some patients develop more severe symptoms than others. Considering our knowledge on the role of vitamin D in modulating the immune system and in inhibiting a hyper activation of the inflammatory response, together with data from observational and clinical studies on vitamin D supplementation, various authors have also suggested a potential role of vitamin D in reducing the severity of the disease [183,184,185,186,187]. Vitamin D is especially known for its ability to reduce the “cytokine storm” that contributes to the pathogenesis of various viral infections, including COVID-19 [188]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T177","span":{"begin":46,"end":50},"obj":"Disease"},{"id":"T178","span":{"begin":857,"end":873},"obj":"Disease"},{"id":"T179","span":{"begin":885,"end":893},"obj":"Disease"}],"attributes":[{"id":"A177","pred":"mondo_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A178","pred":"mondo_id","subj":"T178","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A179","pred":"mondo_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Moreover, a wide variation in the severity of SARS-CoV2 infection’s clinical presentation has been noticed, ranging from absent or minimal symptoms to critical conditions and death. To date, although some risk factors have been identified (age, co-morbidities, etc.), it is not yet completely understood why some patients develop more severe symptoms than others. Considering our knowledge on the role of vitamin D in modulating the immune system and in inhibiting a hyper activation of the inflammatory response, together with data from observational and clinical studies on vitamin D supplementation, various authors have also suggested a potential role of vitamin D in reducing the severity of the disease [183,184,185,186,187]. Vitamin D is especially known for its ability to reduce the “cytokine storm” that contributes to the pathogenesis of various viral infections, including COVID-19 [188]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T454","span":{"begin":10,"end":11},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T455","span":{"begin":90,"end":93},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T456","span":{"begin":433,"end":446},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T457","span":{"begin":465,"end":466},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T458","span":{"begin":473,"end":483},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T459","span":{"begin":639,"end":640},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Moreover, a wide variation in the severity of SARS-CoV2 infection’s clinical presentation has been noticed, ranging from absent or minimal symptoms to critical conditions and death. To date, although some risk factors have been identified (age, co-morbidities, etc.), it is not yet completely understood why some patients develop more severe symptoms than others. Considering our knowledge on the role of vitamin D in modulating the immune system and in inhibiting a hyper activation of the inflammatory response, together with data from observational and clinical studies on vitamin D supplementation, various authors have also suggested a potential role of vitamin D in reducing the severity of the disease [183,184,185,186,187]. Vitamin D is especially known for its ability to reduce the “cytokine storm” that contributes to the pathogenesis of various viral infections, including COVID-19 [188]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T628","span":{"begin":405,"end":414},"obj":"Chemical"},{"id":"T629","span":{"begin":405,"end":412},"obj":"Chemical"},{"id":"T630","span":{"begin":576,"end":585},"obj":"Chemical"},{"id":"T631","span":{"begin":576,"end":583},"obj":"Chemical"},{"id":"T632","span":{"begin":659,"end":668},"obj":"Chemical"},{"id":"T633","span":{"begin":659,"end":666},"obj":"Chemical"},{"id":"T634","span":{"begin":732,"end":741},"obj":"Chemical"},{"id":"T635","span":{"begin":732,"end":739},"obj":"Chemical"}],"attributes":[{"id":"A628","pred":"chebi_id","subj":"T628","obj":"http://purl.obolibrary.org/obo/CHEBI_27300"},{"id":"A629","pred":"chebi_id","subj":"T629","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A630","pred":"chebi_id","subj":"T630","obj":"http://purl.obolibrary.org/obo/CHEBI_27300"},{"id":"A631","pred":"chebi_id","subj":"T631","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A632","pred":"chebi_id","subj":"T632","obj":"http://purl.obolibrary.org/obo/CHEBI_27300"},{"id":"A633","pred":"chebi_id","subj":"T633","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A634","pred":"chebi_id","subj":"T634","obj":"http://purl.obolibrary.org/obo/CHEBI_89324"},{"id":"A635","pred":"chebi_id","subj":"T635","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"}],"text":"Moreover, a wide variation in the severity of SARS-CoV2 infection’s clinical presentation has been noticed, ranging from absent or minimal symptoms to critical conditions and death. To date, although some risk factors have been identified (age, co-morbidities, etc.), it is not yet completely understood why some patients develop more severe symptoms than others. Considering our knowledge on the role of vitamin D in modulating the immune system and in inhibiting a hyper activation of the inflammatory response, together with data from observational and clinical studies on vitamin D supplementation, various authors have also suggested a potential role of vitamin D in reducing the severity of the disease [183,184,185,186,187]. Vitamin D is especially known for its ability to reduce the “cytokine storm” that contributes to the pathogenesis of various viral infections, including COVID-19 [188]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T112","span":{"begin":473,"end":512},"obj":"http://purl.obolibrary.org/obo/GO_0050729"},{"id":"T113","span":{"begin":491,"end":512},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T114","span":{"begin":833,"end":845},"obj":"http://purl.obolibrary.org/obo/GO_0009405"},{"id":"T115","span":{"begin":857,"end":873},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"Moreover, a wide variation in the severity of SARS-CoV2 infection’s clinical presentation has been noticed, ranging from absent or minimal symptoms to critical conditions and death. To date, although some risk factors have been identified (age, co-morbidities, etc.), it is not yet completely understood why some patients develop more severe symptoms than others. Considering our knowledge on the role of vitamin D in modulating the immune system and in inhibiting a hyper activation of the inflammatory response, together with data from observational and clinical studies on vitamin D supplementation, various authors have also suggested a potential role of vitamin D in reducing the severity of the disease [183,184,185,186,187]. Vitamin D is especially known for its ability to reduce the “cytokine storm” that contributes to the pathogenesis of various viral infections, including COVID-19 [188]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T92","span":{"begin":793,"end":807},"obj":"Phenotype"}],"attributes":[{"id":"A92","pred":"hp_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"Moreover, a wide variation in the severity of SARS-CoV2 infection’s clinical presentation has been noticed, ranging from absent or minimal symptoms to critical conditions and death. To date, although some risk factors have been identified (age, co-morbidities, etc.), it is not yet completely understood why some patients develop more severe symptoms than others. Considering our knowledge on the role of vitamin D in modulating the immune system and in inhibiting a hyper activation of the inflammatory response, together with data from observational and clinical studies on vitamin D supplementation, various authors have also suggested a potential role of vitamin D in reducing the severity of the disease [183,184,185,186,187]. Vitamin D is especially known for its ability to reduce the “cytokine storm” that contributes to the pathogenesis of various viral infections, including COVID-19 [188]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T268","span":{"begin":0,"end":181},"obj":"Sentence"},{"id":"T269","span":{"begin":182,"end":363},"obj":"Sentence"},{"id":"T270","span":{"begin":364,"end":731},"obj":"Sentence"},{"id":"T271","span":{"begin":732,"end":900},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Moreover, a wide variation in the severity of SARS-CoV2 infection’s clinical presentation has been noticed, ranging from absent or minimal symptoms to critical conditions and death. To date, although some risk factors have been identified (age, co-morbidities, etc.), it is not yet completely understood why some patients develop more severe symptoms than others. Considering our knowledge on the role of vitamin D in modulating the immune system and in inhibiting a hyper activation of the inflammatory response, together with data from observational and clinical studies on vitamin D supplementation, various authors have also suggested a potential role of vitamin D in reducing the severity of the disease [183,184,185,186,187]. Vitamin D is especially known for its ability to reduce the “cytokine storm” that contributes to the pathogenesis of various viral infections, including COVID-19 [188]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1134","span":{"begin":46,"end":55},"obj":"Species"},{"id":"1135","span":{"begin":313,"end":321},"obj":"Species"},{"id":"1136","span":{"begin":405,"end":414},"obj":"Chemical"},{"id":"1137","span":{"begin":576,"end":585},"obj":"Chemical"},{"id":"1138","span":{"begin":659,"end":668},"obj":"Chemical"},{"id":"1139","span":{"begin":732,"end":741},"obj":"Chemical"},{"id":"1140","span":{"begin":56,"end":65},"obj":"Disease"},{"id":"1141","span":{"begin":175,"end":180},"obj":"Disease"},{"id":"1142","span":{"begin":857,"end":873},"obj":"Disease"},{"id":"1143","span":{"begin":885,"end":893},"obj":"Disease"}],"attributes":[{"id":"A1134","pred":"tao:has_database_id","subj":"1134","obj":"Tax:2697049"},{"id":"A1135","pred":"tao:has_database_id","subj":"1135","obj":"Tax:9606"},{"id":"A1136","pred":"tao:has_database_id","subj":"1136","obj":"MESH:D014807"},{"id":"A1137","pred":"tao:has_database_id","subj":"1137","obj":"MESH:D014807"},{"id":"A1138","pred":"tao:has_database_id","subj":"1138","obj":"MESH:D014807"},{"id":"A1139","pred":"tao:has_database_id","subj":"1139","obj":"MESH:D014807"},{"id":"A1140","pred":"tao:has_database_id","subj":"1140","obj":"MESH:D007239"},{"id":"A1141","pred":"tao:has_database_id","subj":"1141","obj":"MESH:D003643"},{"id":"A1142","pred":"tao:has_database_id","subj":"1142","obj":"MESH:D001102"},{"id":"A1143","pred":"tao:has_database_id","subj":"1143","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Moreover, a wide variation in the severity of SARS-CoV2 infection’s clinical presentation has been noticed, ranging from absent or minimal symptoms to critical conditions and death. To date, although some risk factors have been identified (age, co-morbidities, etc.), it is not yet completely understood why some patients develop more severe symptoms than others. Considering our knowledge on the role of vitamin D in modulating the immune system and in inhibiting a hyper activation of the inflammatory response, together with data from observational and clinical studies on vitamin D supplementation, various authors have also suggested a potential role of vitamin D in reducing the severity of the disease [183,184,185,186,187]. Vitamin D is especially known for its ability to reduce the “cytokine storm” that contributes to the pathogenesis of various viral infections, including COVID-19 [188]."}