PMC:7589163 / 42455-43788 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7589163","sourcedb":"PMC","sourceid":"7589163","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7589163","text":"At the time of writing (3 July 2020), the COVID-19 pandemic has claimed over 500,000 lives worldwide with over 11 million confirmed infections. Different regions of the world have been differently affected by the pandemic, with Northern Italy setting an unfortunate record for incidence and mortality. Different factors might explain these geographical variations, such as the earlier spread of the virus in certain countries or the different preventive measures adopted, the different climates and air-pollution levels, or the different age-composition and social proximity of the communities. A North–South gradient in COVID-19 distribution has been noticed [174,175,176]. Areas along a latitude of 30–50° N with similar low-humidity, temperate weather, showed significant community spread of COVID-19 [177]. Marik and colleagues calculated the case-fatality rate in each state of the US and found increasing mortality with increasing latitude (\u003e40° N) [178]. More recently, another study reported a highly significant, positive correlation between lower death rates and a country’s proximity to the equator [179]. Rhodes et al. described that more northerly countries are currently showing relatively high COVID-19 mortality, with an estimated 4.4% increase in mortality for each 1-degree latitude north of 28 degrees North 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