PMC:7589163 / 41056-42355 JSON TXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T165","span":{"begin":95,"end":111},"obj":"Disease"},{"id":"T166","span":{"begin":240,"end":262},"obj":"Disease"},{"id":"T167","span":{"begin":674,"end":687},"obj":"Disease"}],"attributes":[{"id":"A165","pred":"mondo_id","subj":"T165","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A166","pred":"mondo_id","subj":"T166","obj":"http://purl.obolibrary.org/obo/MONDO_0024355"},{"id":"A167","pred":"mondo_id","subj":"T167","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"In conclusion, there is evidence on the role of vitamin D in regulating the immune response to viral infections, and data from most observational studies confirm an association between lower vitamin D levels and increased susceptibility to respiratory infections. Clinical trials overall show that daily or weekly supplementation of vitamin D is more beneficial in preventing LRTI than bolus or short-term administration, as confirmed by a 2017 meta-analysis by Martineau and colleagues [171], though more research will be needed to fully determine when and how vitamin D should be supplemented. Vitamin D supplementation did not appear to be effective in treating existing infections in pediatric trials, as also described in a 2018 review from Das and colleagues [173]. The different results reached in the above-mentioned studies might be due to the heterogeneity in the baseline vitamin D status of the observed populations; it is also possible that vitamin D receptor’s polymorphisms affect the daily vitamin D requirements of different individuals. Future studies might better clarify which patients will benefit from vitamin D supplementation and which ones will not, which is the best dose to administer in each case, and whether vitamin D status should always be tested before intervention."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T437","span":{"begin":438,"end":439},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T438","span":{"begin":727,"end":728},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T439","span":{"begin":729,"end":733},"obj":"http://purl.obolibrary.org/obo/CLO_0001185"},{"id":"T440","span":{"begin":1272,"end":1278},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"text":"In conclusion, there is evidence on the role of vitamin D in regulating the immune response to viral infections, and data from most observational studies confirm an association between lower vitamin D levels and increased susceptibility to respiratory infections. Clinical trials overall show that daily or weekly supplementation of vitamin D is more beneficial in preventing LRTI than bolus or short-term administration, as confirmed by a 2017 meta-analysis by Martineau and colleagues [171], though more research will be needed to fully determine when and how vitamin D should be supplemented. Vitamin D supplementation did not appear to be effective in treating existing infections in pediatric trials, as also described in a 2018 review from Das and colleagues [173]. The different results reached in the above-mentioned studies might be due to the heterogeneity in the baseline vitamin D status of the observed populations; it is also possible that vitamin D receptor’s polymorphisms affect the daily vitamin D requirements of different individuals. Future studies might better clarify which patients will benefit from vitamin D supplementation and which ones will not, which is the best dose to administer in each case, and whether vitamin D status should always be tested before intervention."}

LitCovid-PD-CHEBI

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T109","span":{"begin":61,"end":91},"obj":"http://purl.obolibrary.org/obo/GO_0050776"},{"id":"T110","span":{"begin":76,"end":91},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T111","span":{"begin":95,"end":111},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"In conclusion, there is evidence on the role of vitamin D in regulating the immune response to viral infections, and data from most observational studies confirm an association between lower vitamin D levels and increased susceptibility to respiratory infections. Clinical trials overall show that daily or weekly supplementation of vitamin D is more beneficial in preventing LRTI than bolus or short-term administration, as confirmed by a 2017 meta-analysis by Martineau and colleagues [171], though more research will be needed to fully determine when and how vitamin D should be supplemented. Vitamin D supplementation did not appear to be effective in treating existing infections in pediatric trials, as also described in a 2018 review from Das and colleagues [173]. The different results reached in the above-mentioned studies might be due to the heterogeneity in the baseline vitamin D status of the observed populations; it is also possible that vitamin D receptor’s polymorphisms affect the daily vitamin D requirements of different individuals. Future studies might better clarify which patients will benefit from vitamin D supplementation and which ones will not, which is the best dose to administer in each case, and whether vitamin D status should always be tested before intervention."}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T89","span":{"begin":222,"end":262},"obj":"Phenotype"}],"attributes":[{"id":"A89","pred":"hp_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/HP_0002205"}],"text":"In conclusion, there is evidence on the role of vitamin D in regulating the immune response to viral infections, and data from most observational studies confirm an association between lower vitamin D levels and increased susceptibility to respiratory infections. Clinical trials overall show that daily or weekly supplementation of vitamin D is more beneficial in preventing LRTI than bolus or short-term administration, as confirmed by a 2017 meta-analysis by Martineau and colleagues [171], though more research will be needed to fully determine when and how vitamin D should be supplemented. Vitamin D supplementation did not appear to be effective in treating existing infections in pediatric trials, as also described in a 2018 review from Das and colleagues [173]. The different results reached in the above-mentioned studies might be due to the heterogeneity in the baseline vitamin D status of the observed populations; it is also possible that vitamin D receptor’s polymorphisms affect the daily vitamin D requirements of different individuals. Future studies might better clarify which patients will benefit from vitamin D supplementation and which ones will not, which is the best dose to administer in each case, and whether vitamin D status should always be tested before intervention."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T248","span":{"begin":0,"end":263},"obj":"Sentence"},{"id":"T249","span":{"begin":264,"end":595},"obj":"Sentence"},{"id":"T250","span":{"begin":596,"end":771},"obj":"Sentence"},{"id":"T251","span":{"begin":772,"end":1054},"obj":"Sentence"},{"id":"T252","span":{"begin":1055,"end":1299},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In conclusion, there is evidence on the role of vitamin D in regulating the immune response to viral infections, and data from most observational studies confirm an association between lower vitamin D levels and increased susceptibility to respiratory infections. Clinical trials overall show that daily or weekly supplementation of vitamin D is more beneficial in preventing LRTI than bolus or short-term administration, as confirmed by a 2017 meta-analysis by Martineau and colleagues [171], though more research will be needed to fully determine when and how vitamin D should be supplemented. Vitamin D supplementation did not appear to be effective in treating existing infections in pediatric trials, as also described in a 2018 review from Das and colleagues [173]. The different results reached in the above-mentioned studies might be due to the heterogeneity in the baseline vitamin D status of the observed populations; it is also possible that vitamin D receptor’s polymorphisms affect the daily vitamin D requirements of different individuals. Future studies might better clarify which patients will benefit from vitamin D supplementation and which ones will not, which is the best dose to administer in each case, and whether vitamin D status should always be tested before intervention."}

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"1066","span":{"begin":954,"end":972},"obj":"Gene"},{"id":"1067","span":{"begin":1097,"end":1105},"obj":"Species"},{"id":"1068","span":{"begin":48,"end":57},"obj":"Chemical"},{"id":"1069","span":{"begin":191,"end":200},"obj":"Chemical"},{"id":"1070","span":{"begin":333,"end":342},"obj":"Chemical"},{"id":"1071","span":{"begin":562,"end":571},"obj":"Chemical"},{"id":"1072","span":{"begin":596,"end":605},"obj":"Chemical"},{"id":"1073","span":{"begin":883,"end":892},"obj":"Chemical"},{"id":"1074","span":{"begin":1006,"end":1015},"obj":"Chemical"},{"id":"1075","span":{"begin":1124,"end":1133},"obj":"Chemical"},{"id":"1076","span":{"begin":1238,"end":1247},"obj":"Chemical"},{"id":"1077","span":{"begin":95,"end":111},"obj":"Disease"},{"id":"1078","span":{"begin":240,"end":262},"obj":"Disease"},{"id":"1079","span":{"begin":674,"end":684},"obj":"Disease"}],"attributes":[{"id":"A1066","pred":"tao:has_database_id","subj":"1066","obj":"Gene:7421"},{"id":"A1067","pred":"tao:has_database_id","subj":"1067","obj":"Tax:9606"},{"id":"A1068","pred":"tao:has_database_id","subj":"1068","obj":"MESH:D014807"},{"id":"A1069","pred":"tao:has_database_id","subj":"1069","obj":"MESH:D014807"},{"id":"A1070","pred":"tao:has_database_id","subj":"1070","obj":"MESH:D014807"},{"id":"A1071","pred":"tao:has_database_id","subj":"1071","obj":"MESH:D014807"},{"id":"A1072","pred":"tao:has_database_id","subj":"1072","obj":"MESH:D014807"},{"id":"A1073","pred":"tao:has_database_id","subj":"1073","obj":"MESH:D014807"},{"id":"A1074","pred":"tao:has_database_id","subj":"1074","obj":"MESH:D014807"},{"id":"A1075","pred":"tao:has_database_id","subj":"1075","obj":"MESH:D014807"},{"id":"A1076","pred":"tao:has_database_id","subj":"1076","obj":"MESH:D014807"},{"id":"A1077","pred":"tao:has_database_id","subj":"1077","obj":"MESH:D001102"},{"id":"A1078","pred":"tao:has_database_id","subj":"1078","obj":"MESH:D012141"},{"id":"A1079","pred":"tao:has_database_id","subj":"1079","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In conclusion, there is evidence on the role of vitamin D in regulating the immune response to viral infections, and data from most observational studies confirm an association between lower vitamin D levels and increased susceptibility to respiratory infections. Clinical trials overall show that daily or weekly supplementation of vitamin D is more beneficial in preventing LRTI than bolus or short-term administration, as confirmed by a 2017 meta-analysis by Martineau and colleagues [171], though more research will be needed to fully determine when and how vitamin D should be supplemented. Vitamin D supplementation did not appear to be effective in treating existing infections in pediatric trials, as also described in a 2018 review from Das and colleagues [173]. The different results reached in the above-mentioned studies might be due to the heterogeneity in the baseline vitamin D status of the observed populations; it is also possible that vitamin D receptor’s polymorphisms affect the daily vitamin D requirements of different individuals. Future studies might better clarify which patients will benefit from vitamin D supplementation and which ones will not, which is the best dose to administer in each case, and whether vitamin D status should always be tested before intervention."}