PMC:7589163 / 28026-28733 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T197","span":{"begin":312,"end":317},"obj":"Body_part"}],"attributes":[{"id":"A197","pred":"fma_id","subj":"T197","obj":"http://purl.org/sig/ont/fma/fma63083"}],"text":"There is currently no definitive consensus regarding the optimal concentration of vitamin D in children and adults. Most authors define vitamin D in normal range from 30 to 100 ng/mL, which might be the optimal range to ensure its immunoregulatory effects; insufficient between 20 and 29 ng/mL, and deficient if serum levels are \u003c20 ng/mL (50 nmol/L), since this level is necessary to maintain optimal bone mineralization and calcium homeostasis in 97.5% of the population [109,110]. Severe vitamin D deficiency is defined as \u003c10 ng/mL; below this cut-off, the risk of developing rickets is very high. Concentrations \u003e100 ng/mL may instead be harmful, although toxicity is more commonly seen over 200 ng/mL."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T67","span":{"begin":312,"end":317},"obj":"Body_part"}],"attributes":[{"id":"A67","pred":"uberon_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"There is currently no definitive consensus regarding the optimal concentration of vitamin D in children and adults. Most authors define vitamin D in normal range from 30 to 100 ng/mL, which might be the optimal range to ensure its immunoregulatory effects; insufficient between 20 and 29 ng/mL, and deficient if serum levels are \u003c20 ng/mL (50 nmol/L), since this level is necessary to maintain optimal bone mineralization and calcium homeostasis in 97.5% of the population [109,110]. Severe vitamin D deficiency is defined as \u003c10 ng/mL; below this cut-off, the risk of developing rickets is very high. Concentrations \u003e100 ng/mL may instead be harmful, although toxicity is more commonly seen over 200 ng/mL."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T119","span":{"begin":580,"end":587},"obj":"Disease"}],"attributes":[{"id":"A119","pred":"mondo_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/MONDO_0005520"}],"text":"There is currently no definitive consensus regarding the optimal concentration of vitamin D in children and adults. Most authors define vitamin D in normal range from 30 to 100 ng/mL, which might be the optimal range to ensure its immunoregulatory effects; insufficient between 20 and 29 ng/mL, and deficient if serum levels are \u003c20 ng/mL (50 nmol/L), since this level is necessary to maintain optimal bone mineralization and calcium homeostasis in 97.5% of the population [109,110]. Severe vitamin D deficiency is defined as \u003c10 ng/mL; below this cut-off, the risk of developing rickets is very high. Concentrations \u003e100 ng/mL may instead be harmful, although toxicity is more commonly seen over 200 ng/mL."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T350","span":{"begin":402,"end":406},"obj":"http://purl.obolibrary.org/obo/UBERON_0002481"}],"text":"There is currently no definitive consensus regarding the optimal concentration of vitamin D in children and adults. Most authors define vitamin D in normal range from 30 to 100 ng/mL, which might be the optimal range to ensure its immunoregulatory effects; insufficient between 20 and 29 ng/mL, and deficient if serum levels are \u003c20 ng/mL (50 nmol/L), since this level is necessary to maintain optimal bone mineralization and calcium homeostasis in 97.5% of the population [109,110]. Severe vitamin D deficiency is defined as \u003c10 ng/mL; below this cut-off, the risk of developing rickets is very high. Concentrations \u003e100 ng/mL may instead be harmful, although toxicity is more commonly seen over 200 ng/mL."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T464","span":{"begin":82,"end":91},"obj":"Chemical"},{"id":"T465","span":{"begin":82,"end":89},"obj":"Chemical"},{"id":"T466","span":{"begin":136,"end":145},"obj":"Chemical"},{"id":"T467","span":{"begin":136,"end":143},"obj":"Chemical"},{"id":"T468","span":{"begin":426,"end":433},"obj":"Chemical"},{"id":"T470","span":{"begin":491,"end":500},"obj":"Chemical"},{"id":"T471","span":{"begin":491,"end":498},"obj":"Chemical"}],"attributes":[{"id":"A464","pred":"chebi_id","subj":"T464","obj":"http://purl.obolibrary.org/obo/CHEBI_27300"},{"id":"A465","pred":"chebi_id","subj":"T465","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A466","pred":"chebi_id","subj":"T466","obj":"http://purl.obolibrary.org/obo/CHEBI_27300"},{"id":"A467","pred":"chebi_id","subj":"T467","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A468","pred":"chebi_id","subj":"T468","obj":"http://purl.obolibrary.org/obo/CHEBI_22984"},{"id":"A469","pred":"chebi_id","subj":"T468","obj":"http://purl.obolibrary.org/obo/CHEBI_29320"},{"id":"A470","pred":"chebi_id","subj":"T470","obj":"http://purl.obolibrary.org/obo/CHEBI_27300"},{"id":"A471","pred":"chebi_id","subj":"T471","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"}],"text":"There is currently no definitive consensus regarding the optimal concentration of vitamin D in children and adults. Most authors define vitamin D in normal range from 30 to 100 ng/mL, which might be the optimal range to ensure its immunoregulatory effects; insufficient between 20 and 29 ng/mL, and deficient if serum levels are \u003c20 ng/mL (50 nmol/L), since this level is necessary to maintain optimal bone mineralization and calcium homeostasis in 97.5% of the population [109,110]. Severe vitamin D deficiency is defined as \u003c10 ng/mL; below this cut-off, the risk of developing rickets is very high. Concentrations \u003e100 ng/mL may instead be harmful, although toxicity is more commonly seen over 200 ng/mL."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T102","span":{"begin":402,"end":421},"obj":"http://purl.obolibrary.org/obo/GO_0030282"},{"id":"T103","span":{"begin":407,"end":421},"obj":"http://purl.obolibrary.org/obo/GO_0110148"},{"id":"T104","span":{"begin":434,"end":445},"obj":"http://purl.obolibrary.org/obo/GO_0042592"}],"text":"There is currently no definitive consensus regarding the optimal concentration of vitamin D in children and adults. Most authors define vitamin D in normal range from 30 to 100 ng/mL, which might be the optimal range to ensure its immunoregulatory effects; insufficient between 20 and 29 ng/mL, and deficient if serum levels are \u003c20 ng/mL (50 nmol/L), since this level is necessary to maintain optimal bone mineralization and calcium homeostasis in 97.5% of the population [109,110]. Severe vitamin D deficiency is defined as \u003c10 ng/mL; below this cut-off, the risk of developing rickets is very high. Concentrations \u003e100 ng/mL may instead be harmful, although toxicity is more commonly seen over 200 ng/mL."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T55","span":{"begin":491,"end":511},"obj":"Phenotype"},{"id":"T56","span":{"begin":580,"end":587},"obj":"Phenotype"}],"attributes":[{"id":"A55","pred":"hp_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/HP_0100512"},{"id":"A56","pred":"hp_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/HP_0002748"}],"text":"There is currently no definitive consensus regarding the optimal concentration of vitamin D in children and adults. Most authors define vitamin D in normal range from 30 to 100 ng/mL, which might be the optimal range to ensure its immunoregulatory effects; insufficient between 20 and 29 ng/mL, and deficient if serum levels are \u003c20 ng/mL (50 nmol/L), since this level is necessary to maintain optimal bone mineralization and calcium homeostasis in 97.5% of the population [109,110]. Severe vitamin D deficiency is defined as \u003c10 ng/mL; below this cut-off, the risk of developing rickets is very high. Concentrations \u003e100 ng/mL may instead be harmful, although toxicity is more commonly seen over 200 ng/mL."}

{"project":"LitCovid-sentences","denotations":[{"id":"T187","span":{"begin":0,"end":115},"obj":"Sentence"},{"id":"T188","span":{"begin":116,"end":483},"obj":"Sentence"},{"id":"T189","span":{"begin":484,"end":601},"obj":"Sentence"},{"id":"T190","span":{"begin":602,"end":707},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"There is currently no definitive consensus regarding the optimal concentration of vitamin D in children and adults. Most authors define vitamin D in normal range from 30 to 100 ng/mL, which might be the optimal range to ensure its immunoregulatory effects; insufficient between 20 and 29 ng/mL, and deficient if serum levels are \u003c20 ng/mL (50 nmol/L), since this level is necessary to maintain optimal bone mineralization and calcium homeostasis in 97.5% of the population [109,110]. Severe vitamin D deficiency is defined as \u003c10 ng/mL; below this cut-off, the risk of developing rickets is very high. Concentrations \u003e100 ng/mL may instead be harmful, although toxicity is more commonly seen over 200 ng/mL."}

{"project":"LitCovid-PubTator","denotations":[{"id":"745","span":{"begin":704,"end":706},"obj":"Gene"},{"id":"746","span":{"begin":625,"end":627},"obj":"Gene"},{"id":"747","span":{"begin":533,"end":535},"obj":"Gene"},{"id":"748","span":{"begin":336,"end":338},"obj":"Gene"},{"id":"749","span":{"begin":291,"end":293},"obj":"Gene"},{"id":"750","span":{"begin":180,"end":182},"obj":"Gene"},{"id":"751","span":{"begin":95,"end":103},"obj":"Species"},{"id":"752","span":{"begin":348,"end":349},"obj":"Gene"},{"id":"753","span":{"begin":82,"end":91},"obj":"Chemical"},{"id":"754","span":{"begin":136,"end":145},"obj":"Chemical"},{"id":"755","span":{"begin":426,"end":433},"obj":"Chemical"},{"id":"756","span":{"begin":491,"end":500},"obj":"Chemical"},{"id":"757","span":{"begin":661,"end":669},"obj":"Disease"}],"attributes":[{"id":"A745","pred":"tao:has_database_id","subj":"745","obj":"Gene:21832"},{"id":"A746","pred":"tao:has_database_id","subj":"746","obj":"Gene:21832"},{"id":"A747","pred":"tao:has_database_id","subj":"747","obj":"Gene:21832"},{"id":"A748","pred":"tao:has_database_id","subj":"748","obj":"Gene:21832"},{"id":"A749","pred":"tao:has_database_id","subj":"749","obj":"Gene:21832"},{"id":"A750","pred":"tao:has_database_id","subj":"750","obj":"Gene:21832"},{"id":"A751","pred":"tao:has_database_id","subj":"751","obj":"Tax:9606"},{"id":"A752","pred":"tao:has_database_id","subj":"752","obj":"Gene:21832"},{"id":"A753","pred":"tao:has_database_id","subj":"753","obj":"MESH:D014807"},{"id":"A754","pred":"tao:has_database_id","subj":"754","obj":"MESH:D014807"},{"id":"A755","pred":"tao:has_database_id","subj":"755","obj":"MESH:D002118"},{"id":"A756","pred":"tao:has_database_id","subj":"756","obj":"MESH:D014807"},{"id":"A757","pred":"tao:has_database_id","subj":"757","obj":"MESH:D064420"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"There is currently no definitive consensus regarding the optimal concentration of vitamin D in children and adults. Most authors define vitamin D in normal range from 30 to 100 ng/mL, which might be the optimal range to ensure its immunoregulatory effects; insufficient between 20 and 29 ng/mL, and deficient if serum levels are \u003c20 ng/mL (50 nmol/L), since this level is necessary to maintain optimal bone mineralization and calcium homeostasis in 97.5% of the population [109,110]. Severe vitamin D deficiency is defined as \u003c10 ng/mL; below this cut-off, the risk of developing rickets is very high. Concentrations \u003e100 ng/mL may instead be harmful, although toxicity is more commonly seen over 200 ng/mL."}