PMC:7589163 / 25768-26896
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T176 | 89-102 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T177 | 279-292 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T178 | 293-298 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T179 | 307-318 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T180 | 323-334 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T181 | 367-372 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T182 | 451-462 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T183 | 610-625 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
| T184 | 620-625 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T185 | 682-687 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T186 | 787-796 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T187 | 986-994 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T64 | 89-102 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T65 | 279-292 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T66 | 638-644 | Body_part | denotes | organs | http://purl.obolibrary.org/obo/UBERON_0000062 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T110 | 920-924 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T111 | 1112-1127 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T112 | 1118-1127 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T315 | 35-42 | http://purl.obolibrary.org/obo/CLO_0009985 | denotes | focused |
| T316 | 89-102 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T317 | 220-228 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptides |
| T318 | 254-259 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T319 | 279-292 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T320 | 293-298 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T321 | 344-354 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T322 | 367-372 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T323 | 439-447 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T324 | 534-542 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T325 | 610-625 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cells |
| T326 | 629-644 | http://purl.obolibrary.org/obo/UBERON_0004177 | denotes | lymphoid organs |
| T327 | 680-687 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T328 | 901-908 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T329 | 1103-1109 | http://purl.obolibrary.org/obo/UBERON_0001456 | denotes | facing |
| T330 | 1110-1111 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T422 | 61-70 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T423 | 61-68 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T424 | 158-167 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T425 | 158-165 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T426 | 206-219 | Chemical | denotes | antimicrobial | http://purl.obolibrary.org/obo/CHEBI_33281 |
| T427 | 220-228 | Chemical | denotes | peptides | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T428 | 260-264 | Chemical | denotes | beta | http://purl.obolibrary.org/obo/CHEBI_10545 |
| T429 | 265-273 | Chemical | denotes | defensin | http://purl.obolibrary.org/obo/CHEBI_82761 |
| T430 | 397-406 | Chemical | denotes | Vitamin D | http://purl.obolibrary.org/obo/CHEBI_89324 |
| T431 | 397-404 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T432 | 425-438 | Chemical | denotes | antimicrobial | http://purl.obolibrary.org/obo/CHEBI_33281 |
| T433 | 546-551 | Chemical | denotes | NADPH | http://purl.obolibrary.org/obo/CHEBI_16474|http://purl.obolibrary.org/obo/CHEBI_57783 |
| T435 | 668-676 | Chemical | denotes | antigens | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T436 | 725-734 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T437 | 725-732 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T438 | 1052-1061 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T439 | 1052-1059 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T94 | 507-516 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T95 | 507-516 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T96 | 1112-1127 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T52 | 948-964 | Phenotype | denotes | hypercytokinemia | http://purl.obolibrary.org/obo/HP_0033041 |
| T53 | 986-1000 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T176 | 0-103 | Sentence | denotes | For the purpose of this review, we focused on the effects of vitamin D in modulating the immune system. |
| T177 | 104-396 | Sentence | denotes | Several mechanisms have been described [83]: firstly, vitamin D was found to induce the production of antimicrobial peptides such as cathelicidin and human beta-defensin from immune system cells such as neutrophils and macrophages and from epithelial respiratory cells [81,82,83,84,85,86,87]. |
| T178 | 397-693 | Sentence | denotes | Vitamin D also enhances the antimicrobial activity of macrophages by increasing TLR and CD14 expression [88], autophagy [89,90], and the activity of NADPH-dependent oxidase [91]; it also promotes the migration of dendritic cells to lymphoid organs where they can present antigens to T cells [92]. |
| T179 | 694-1019 | Sentence | denotes | On the other side of the coin, vitamin D can also inhibit the production of pro inflammatory cytokines, which might appear counterproductive [93]; it is known, however, that the pathogenicity of respiratory viruses, including SARS-CoV2, can be linked to hypercytokinemia up to the so-called “cytokine storm” [94,95,96,97,98]. |
| T180 | 1020-1128 | Sentence | denotes | This immunoregulatory effect of vitamin D can thus be beneficial to the host while facing a viral infection. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 680 | 485-489 | Gene | denotes | CD14 | Gene:929 |
| 681 | 254-259 | Species | denotes | human | Tax:9606 |
| 682 | 920-929 | Species | denotes | SARS-CoV2 | Tax:2697049 |
| 683 | 355-366 | Species | denotes | respiratory | Tax:12814 |
| 684 | 889-900 | Species | denotes | respiratory | Tax:12814 |
| 685 | 61-70 | Chemical | denotes | vitamin D | MESH:D014807 |
| 686 | 158-167 | Chemical | denotes | vitamin D | MESH:D014807 |
| 687 | 397-406 | Chemical | denotes | Vitamin D | MESH:D014807 |
| 688 | 725-734 | Chemical | denotes | vitamin D | MESH:D014807 |
| 689 | 1052-1061 | Chemical | denotes | vitamin D | MESH:D014807 |
| 690 | 948-964 | Disease | denotes | hypercytokinemia | |
| 691 | 1112-1127 | Disease | denotes | viral infection | MESH:D001102 |