PMC:7589163 / 23831-28002
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T159 | 57-64 | Body_part | denotes | hormone | http://purl.org/sig/ont/fma/fma12278 |
| T160 | 99-103 | Body_part | denotes | skin | http://purl.org/sig/ont/fma/fma7163 |
| T161 | 421-425 | Body_part | denotes | skin | http://purl.org/sig/ont/fma/fma7163 |
| T162 | 450-472 | Body_part | denotes | gastrointestinal tract | http://purl.org/sig/ont/fma/fma71132 |
| T163 | 499-504 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T164 | 526-533 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T165 | 549-554 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T166 | 749-756 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T167 | 1061-1066 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T168 | 1071-1078 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T169 | 1094-1107 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T170 | 1113-1117 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T171 | 1144-1154 | Body_part | denotes | chromosome | http://purl.org/sig/ont/fma/fma67093 |
| T172 | 1358-1367 | Body_part | denotes | intestine | http://purl.org/sig/ont/fma/fma7199 |
| T173 | 1392-1399 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T174 | 1446-1457 | Body_part | denotes | osteoclasts | http://purl.org/sig/ont/fma/fma66781 |
| T175 | 1855-1865 | Body_part | denotes | epithelium | http://purl.org/sig/ont/fma/fma9639 |
| T176 | 2026-2039 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T177 | 2216-2229 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T178 | 2230-2235 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T179 | 2244-2255 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T180 | 2260-2271 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T181 | 2304-2309 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T182 | 2388-2399 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T183 | 2547-2562 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
| T184 | 2557-2562 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T185 | 2619-2624 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T186 | 2724-2733 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T187 | 2923-2931 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T188 | 3186-3191 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T189 | 3459-3470 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T190 | 3487-3498 | Body_part | denotes | macrophagic | http://purl.org/sig/ont/fma/fma63261 |
| T191 | 3499-3508 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T192 | 3606-3619 | Body_part | denotes | keratinocytes | http://purl.org/sig/ont/fma/fma62879 |
| T193 | 3775-3780 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T194 | 3824-3829 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T195 | 3853-3858 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T196 | 3983-3988 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T55 | 99-103 | Body_part | denotes | skin | http://purl.obolibrary.org/obo/UBERON_0000014 |
| T56 | 335-344 | Body_part | denotes | egg yolks | http://purl.obolibrary.org/obo/UBERON_0007378 |
| T57 | 335-338 | Body_part | denotes | egg | http://purl.obolibrary.org/obo/UBERON_0007379 |
| T58 | 421-425 | Body_part | denotes | skin | http://purl.obolibrary.org/obo/UBERON_0000014 |
| T59 | 499-504 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T60 | 549-554 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T61 | 1094-1107 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T62 | 1358-1367 | Body_part | denotes | intestine | http://purl.obolibrary.org/obo/UBERON_0000160 |
| T63 | 1855-1865 | Body_part | denotes | epithelium | http://purl.obolibrary.org/obo/UBERON_0000483 |
| T64 | 2026-2039 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T65 | 2216-2229 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
| T66 | 2575-2581 | Body_part | denotes | organs | http://purl.obolibrary.org/obo/UBERON_0000062 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T106 | 1211-1233 | Disease | denotes | respiratory infections | http://purl.obolibrary.org/obo/MONDO_0024355 |
| T107 | 1533-1540 | Disease | denotes | rickets | http://purl.obolibrary.org/obo/MONDO_0005520 |
| T108 | 1545-1557 | Disease | denotes | osteomalacia | http://purl.obolibrary.org/obo/MONDO_0001068 |
| T109 | 1903-1930 | Disease | denotes | gastrointestinal infections | http://purl.obolibrary.org/obo/MONDO_0043424 |
| T110 | 2857-2861 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T111 | 3049-3064 | Disease | denotes | viral infection | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T112 | 3055-3064 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T113 | 3094-3103 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T114 | 3106-3115 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T115 | 3131-3136 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T116 | 3262-3271 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T117 | 3370-3376 | Disease | denotes | Dengue | http://purl.obolibrary.org/obo/MONDO_0005502 |
| T118 | 3377-3386 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T273 | 43-44 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T274 | 45-48 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | fat |
| T275 | 99-103 | http://purl.obolibrary.org/obo/UBERON_0000014 | denotes | skin |
| T276 | 99-103 | http://purl.obolibrary.org/obo/UBERON_0001003 | denotes | skin |
| T277 | 99-103 | http://purl.obolibrary.org/obo/UBERON_0002097 | denotes | skin |
| T278 | 99-103 | http://purl.obolibrary.org/obo/UBERON_0002199 | denotes | skin |
| T279 | 99-103 | http://www.ebi.ac.uk/efo/EFO_0000962 | denotes | skin |
| T280 | 177-179 | http://purl.obolibrary.org/obo/CLO_0002675 | denotes | D3 |
| T281 | 190-191 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T282 | 268-270 | http://purl.obolibrary.org/obo/CLO_0002668 | denotes | D2 |
| T283 | 274-276 | http://purl.obolibrary.org/obo/CLO_0002675 | denotes | D3 |
| T284 | 318-322 | http://purl.obolibrary.org/obo/NCBITaxon_117565 | denotes | fish |
| T285 | 324-328 | http://purl.obolibrary.org/obo/NCBITaxon_117565 | denotes | fish |
| T286 | 421-425 | http://purl.obolibrary.org/obo/UBERON_0000014 | denotes | skin |
| T287 | 421-425 | http://purl.obolibrary.org/obo/UBERON_0001003 | denotes | skin |
| T288 | 421-425 | http://purl.obolibrary.org/obo/UBERON_0002097 | denotes | skin |
| T289 | 421-425 | http://purl.obolibrary.org/obo/UBERON_0002199 | denotes | skin |
| T290 | 421-425 | http://www.ebi.ac.uk/efo/EFO_0000962 | denotes | skin |
| T291 | 450-472 | http://purl.obolibrary.org/obo/UBERON_0005409 | denotes | gastrointestinal tract |
| T292 | 499-504 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T293 | 499-504 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T294 | 549-554 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T295 | 549-554 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T296 | 749-756 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T297 | 749-756 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T298 | 749-756 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T299 | 795-801 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T300 | 907-908 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T301 | 1010-1015 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | genes |
| T302 | 1061-1066 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T303 | 1094-1107 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T304 | 1113-1117 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T305 | 1358-1367 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestine |
| T306 | 1358-1367 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestine |
| T307 | 1392-1399 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T308 | 1392-1399 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T309 | 1392-1399 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T310 | 1416-1420 | http://purl.obolibrary.org/obo/UBERON_0002481 | denotes | bone |
| T311 | 1596-1599 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T312 | 1676-1680 | http://purl.obolibrary.org/obo/UBERON_0002481 | denotes | bone |
| T313 | 1855-1865 | http://purl.obolibrary.org/obo/UBERON_0000483 | denotes | epithelium |
| T314 | 1881-1882 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T315 | 1972-1979 | http://purl.obolibrary.org/obo/CLO_0009985 | denotes | focused |
| T316 | 2026-2039 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T317 | 2157-2165 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptides |
| T318 | 2191-2196 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T319 | 2216-2229 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T320 | 2230-2235 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T321 | 2281-2291 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T322 | 2304-2309 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T323 | 2376-2384 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T324 | 2471-2479 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T325 | 2547-2562 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cells |
| T326 | 2566-2581 | http://purl.obolibrary.org/obo/UBERON_0004177 | denotes | lymphoid organs |
| T327 | 2617-2624 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T328 | 2838-2845 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T329 | 3040-3046 | http://purl.obolibrary.org/obo/UBERON_0001456 | denotes | facing |
| T330 | 3047-3048 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T331 | 3069-3072 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T332 | 3104-3105 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T333 | 3165-3169 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
| T334 | 3186-3191 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T335 | 3427-3435 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T336 | 3449-3458 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T337 | 3472-3475 | http://purl.obolibrary.org/obo/CLO_0054060 | denotes | 102 |
| T338 | 3606-3619 | http://purl.obolibrary.org/obo/CL_0000312 | denotes | keratinocytes |
| T339 | 3661-3669 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T340 | 3753-3758 | http://purl.obolibrary.org/obo/PR_000001350 | denotes | FOXP3 |
| T341 | 3773-3780 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T342 | 3824-3829 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T343 | 3833-3838 | http://purl.obolibrary.org/obo/PR_000001350 | denotes | FOXP3 |
| T344 | 3853-3858 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T345 | 3860-3865 | http://purl.obolibrary.org/obo/CL_0000792 | denotes | T reg |
| T346 | 3899-3907 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T347 | 3981-3988 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T348 | 4020-4021 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T349 | 4159-4164 | http://purl.obolibrary.org/obo/CL_0000792 | denotes | Tregs |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T382 | 30-39 | Chemical | denotes | Vitamin D | http://purl.obolibrary.org/obo/CHEBI_89324 |
| T383 | 30-37 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T384 | 57-64 | Chemical | denotes | hormone | http://purl.obolibrary.org/obo/CHEBI_24621 |
| T385 | 169-179 | Chemical | denotes | vitamin D3 | http://purl.obolibrary.org/obo/CHEBI_28940 |
| T386 | 169-176 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T387 | 260-270 | Chemical | denotes | vitamin D2 | http://purl.obolibrary.org/obo/CHEBI_28934 |
| T388 | 260-267 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T389 | 268-270 | Chemical | denotes | D2 | http://purl.obolibrary.org/obo/CHEBI_29294 |
| T390 | 298-307 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T391 | 298-305 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T392 | 358-367 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T393 | 358-365 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T394 | 392-401 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T395 | 392-399 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T396 | 508-517 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T397 | 508-515 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T398 | 526-533 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T399 | 555-564 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T400 | 555-562 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T401 | 584-591 | Chemical | denotes | hydroxy | http://purl.obolibrary.org/obo/CHEBI_43176 |
| T402 | 592-601 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T403 | 592-599 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T404 | 644-653 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T405 | 644-651 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T406 | 709-716 | Chemical | denotes | hydroxy | http://purl.obolibrary.org/obo/CHEBI_43176 |
| T407 | 717-726 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T408 | 717-724 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T409 | 917-926 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T410 | 917-924 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T411 | 1274-1283 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T412 | 1274-1281 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T413 | 1299-1306 | Chemical | denotes | calcium | http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320 |
| T415 | 1332-1339 | Chemical | denotes | calcium | http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320 |
| T417 | 1586-1595 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T418 | 1586-1593 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T419 | 1652-1659 | Chemical | denotes | mineral | http://purl.obolibrary.org/obo/CHEBI_46662 |
| T420 | 1796-1805 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T421 | 1796-1803 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T422 | 1998-2007 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T423 | 1998-2005 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T424 | 2095-2104 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T425 | 2095-2102 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T426 | 2143-2156 | Chemical | denotes | antimicrobial | http://purl.obolibrary.org/obo/CHEBI_33281 |
| T427 | 2157-2165 | Chemical | denotes | peptides | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T428 | 2197-2201 | Chemical | denotes | beta | http://purl.obolibrary.org/obo/CHEBI_10545 |
| T429 | 2202-2210 | Chemical | denotes | defensin | http://purl.obolibrary.org/obo/CHEBI_82761 |
| T430 | 2334-2343 | Chemical | denotes | Vitamin D | http://purl.obolibrary.org/obo/CHEBI_89324 |
| T431 | 2334-2341 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T432 | 2362-2375 | Chemical | denotes | antimicrobial | http://purl.obolibrary.org/obo/CHEBI_33281 |
| T433 | 2483-2488 | Chemical | denotes | NADPH | http://purl.obolibrary.org/obo/CHEBI_16474|http://purl.obolibrary.org/obo/CHEBI_57783 |
| T435 | 2605-2613 | Chemical | denotes | antigens | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T436 | 2662-2671 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T437 | 2662-2669 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T438 | 2989-2998 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T439 | 2989-2996 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T440 | 3121-3124 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T441 | 3125-3129 | Chemical | denotes | beta | http://purl.obolibrary.org/obo/CHEBI_10545 |
| T442 | 3165-3167 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T444 | 3174-3176 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T446 | 3235-3244 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T447 | 3235-3242 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T448 | 3281-3290 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T449 | 3394-3403 | Chemical | denotes | Vitamin D | http://purl.obolibrary.org/obo/CHEBI_89324 |
| T450 | 3394-3401 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T451 | 3439-3442 | Chemical | denotes | IFN | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T452 | 3443-3448 | Chemical | denotes | gamma | http://purl.obolibrary.org/obo/CHEBI_30212 |
| T453 | 3541-3544 | Chemical | denotes | MKP | http://purl.obolibrary.org/obo/CHEBI_63036 |
| T454 | 3597-3600 | Chemical | denotes | MMP | http://purl.obolibrary.org/obo/CHEBI_340824|http://purl.obolibrary.org/obo/CHEBI_59761 |
| T456 | 3725-3734 | Chemical | denotes | Vitamin D | http://purl.obolibrary.org/obo/CHEBI_89324 |
| T457 | 3725-3732 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T458 | 3970-3972 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T460 | 4080-4089 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T461 | 4080-4087 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T84 | 5-15 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | Metabolism |
| T85 | 480-491 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transported |
| T86 | 730-741 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transported |
| T87 | 958-968 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T88 | 976-989 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T89 | 1307-1318 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
| T90 | 1404-1431 | http://purl.obolibrary.org/obo/GO_0046852 | denotes | stimulating bone remodeling |
| T91 | 1416-1431 | http://purl.obolibrary.org/obo/GO_0046849 | denotes | bone remodeling |
| T92 | 1660-1671 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
| T93 | 1706-1716 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulation |
| T94 | 2444-2453 | http://purl.obolibrary.org/obo/GO_0016236 | denotes | autophagy |
| T95 | 2444-2453 | http://purl.obolibrary.org/obo/GO_0006914 | denotes | autophagy |
| T96 | 3049-3064 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infection |
| T97 | 3137-3145 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T98 | 3137-3145 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T99 | 3137-3145 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T100 | 3137-3145 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T101 | 3939-3948 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T48 | 1211-1233 | Phenotype | denotes | respiratory infections | http://purl.obolibrary.org/obo/HP_0011947 |
| T49 | 1533-1540 | Phenotype | denotes | rickets | http://purl.obolibrary.org/obo/HP_0002748 |
| T50 | 1545-1557 | Phenotype | denotes | osteomalacia | http://purl.obolibrary.org/obo/HP_0002749 |
| T51 | 1903-1930 | Phenotype | denotes | gastrointestinal infections | http://purl.obolibrary.org/obo/HP_0004798 |
| T52 | 2885-2901 | Phenotype | denotes | hypercytokinemia | http://purl.obolibrary.org/obo/HP_0033041 |
| T53 | 2923-2937 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T54 | 3131-3136 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T164 | 0-4 | Sentence | denotes | 5.1. |
| T165 | 5-29 | Sentence | denotes | Metabolism and Functions |
| T166 | 30-385 | Sentence | denotes | Vitamin D is a fat-soluble hormone that is mainly synthesized in the skin after exposure to ultraviolet rays from sunlight (in the form of vitamin D3), and, to a lesser extent, is derived from dietary intake in the form of either vitamin D2 or D3 (the main sources of vitamin D are fatty fish, fish oils, egg yolks, cheese, and vitamin D-fortified foods). |
| T167 | 386-541 | Sentence | denotes | After vitamin D is produced in the skin or absorbed through the gastrointestinal tract, it is transported to the liver by vitamin D-binding protein (VDBP). |
| T168 | 542-699 | Sentence | denotes | In the liver vitamin D is converted to 25 hydroxy vitamin D (25(OH)D), which is monitored to evaluate vitamin D status because of its half-life of 2–3 weeks. |
| T169 | 700-845 | Sentence | denotes | Next, 25 hydroxy vitamin D is transported to the kidneys, where it is finally converted to its active form, 1,25 dihydroxyvitamin D (1,25(OH)2D). |
| T170 | 846-1016 | Sentence | denotes | The actions of 1,25(OH)2D are mediated through ligation with a nuclear vitamin D receptor (VDR), leading to the regulation of the transcription of over 1000 target genes. |
| T171 | 1017-1108 | Sentence | denotes | VDR is widely distributed in many different cells and tissues, including the immune system. |
| T172 | 1109-1248 | Sentence | denotes | VDR gene polymorphisms, located on chromosome 12q13.1, have been associated with higher prevalence of respiratory infections [74,75,76,77]. |
| T173 | 1249-1465 | Sentence | denotes | One of the main roles of vitamin D is to maintain calcium homeostasis by promoting calcium absorption in the intestine and reabsorption in the kidneys and stimulating bone remodeling by increasing osteoclasts number. |
| T174 | 1466-1782 | Sentence | denotes | This effect was the first to be discovered, studying the causes of rickets and osteomalacia, but now it is thought that vitamin D has physiological effects much broader that its role in mineral homeostasis and bone function [78], including regulation of immunity, fetal development [79], and pulmonary function [80]. |
| T175 | 1783-1936 | Sentence | denotes | In addition, vitamin D can also induce cathelicidin in gastrointestinal epithelium [81] and plays a role in controlling gastrointestinal infections [82]. |
| T176 | 1937-2040 | Sentence | denotes | For the purpose of this review, we focused on the effects of vitamin D in modulating the immune system. |
| T177 | 2041-2333 | Sentence | denotes | Several mechanisms have been described [83]: firstly, vitamin D was found to induce the production of antimicrobial peptides such as cathelicidin and human beta-defensin from immune system cells such as neutrophils and macrophages and from epithelial respiratory cells [81,82,83,84,85,86,87]. |
| T178 | 2334-2630 | Sentence | denotes | Vitamin D also enhances the antimicrobial activity of macrophages by increasing TLR and CD14 expression [88], autophagy [89,90], and the activity of NADPH-dependent oxidase [91]; it also promotes the migration of dendritic cells to lymphoid organs where they can present antigens to T cells [92]. |
| T179 | 2631-2956 | Sentence | denotes | On the other side of the coin, vitamin D can also inhibit the production of pro inflammatory cytokines, which might appear counterproductive [93]; it is known, however, that the pathogenicity of respiratory viruses, including SARS-CoV2, can be linked to hypercytokinemia up to the so-called “cytokine storm” [94,95,96,97,98]. |
| T180 | 2957-3065 | Sentence | denotes | This immunoregulatory effect of vitamin D can thus be beneficial to the host while facing a viral infection. |
| T181 | 3066-3393 | Sentence | denotes | It has been reported during influenza A infection that IFN-beta, tumor necrosis factor (TNF)-alfa, IL-8 and IL-6 in the lungs were reduced in response to treatment with vitamin D [99]; during RSV infection the NfkB inhibitor was induced [100]; similar immunomodulatory effects were also described during Dengue infection [101]. |
| T182 | 3394-3724 | Sentence | denotes | Vitamin D can suppress excessive activity of IFN gamma-activated macrophages [102]; decrease macrophagic cytokines release through upregulation of MKP-1 [103]; reduce the production of metalloproteinase MMP-9 in keratinocytes, whose excessive and potentially harmful activity is induced by TNF alfa during hyperinflammation [104]. |
| T183 | 3725-3995 | Sentence | denotes | Vitamin D can also regulate FOXP3 expression in T cells, thus inducing the differentiation of this cells to FOXP3+ T regulatory cells (T reg), which have an immunosuppressor activity [105,106], and can promote the secretion of anti-inflammatory IL-10 from T cells [107]. |
| T184 | 3996-4171 | Sentence | denotes | It was also reported in a placebo-controlled trial on healthy adults that high dose vitamin D supplementation significantly increased the frequency of circulating Tregs [108]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 628 | 508-533 | Gene | denotes | vitamin D-binding protein | Gene:2638 |
| 629 | 535-539 | Gene | denotes | VDBP | Gene:2638 |
| 630 | 30-39 | Chemical | denotes | Vitamin D | MESH:D014807 |
| 631 | 169-179 | Chemical | denotes | vitamin D3 | MESH:D002762 |
| 632 | 260-270 | Chemical | denotes | vitamin D2 | MESH:D004872 |
| 633 | 274-276 | Chemical | denotes | D3 | MESH:D002762 |
| 634 | 298-307 | Chemical | denotes | vitamin D | MESH:D014807 |
| 635 | 358-367 | Chemical | denotes | vitamin D | MESH:D014807 |
| 636 | 392-401 | Chemical | denotes | vitamin D | MESH:D014807 |
| 637 | 555-564 | Chemical | denotes | vitamin D | MESH:D014807 |
| 638 | 581-601 | Chemical | denotes | 25 hydroxy vitamin D | MESH:C104450 |
| 639 | 603-610 | Chemical | denotes | 25(OH)D | |
| 640 | 644-653 | Chemical | denotes | vitamin D | MESH:D014807 |
| 641 | 706-726 | Chemical | denotes | 25 hydroxy vitamin D | MESH:C104450 |
| 642 | 808-831 | Chemical | denotes | 1,25 dihydroxyvitamin D | MESH:C097949 |
| 643 | 833-843 | Chemical | denotes | 1,25(OH)2D | |
| 656 | 917-935 | Gene | denotes | vitamin D receptor | Gene:7421 |
| 657 | 937-940 | Gene | denotes | VDR | Gene:7421 |
| 658 | 1017-1020 | Gene | denotes | VDR | Gene:7421 |
| 659 | 1109-1112 | Gene | denotes | VDR | Gene:7421 |
| 660 | 1274-1283 | Chemical | denotes | vitamin D | MESH:D014807 |
| 661 | 1299-1306 | Chemical | denotes | calcium | MESH:D002118 |
| 662 | 1332-1339 | Chemical | denotes | calcium | MESH:D002118 |
| 663 | 1586-1595 | Chemical | denotes | vitamin D | MESH:D014807 |
| 664 | 1796-1805 | Chemical | denotes | vitamin D | MESH:D014807 |
| 665 | 1211-1233 | Disease | denotes | respiratory infections | MESH:D012141 |
| 666 | 1545-1557 | Disease | denotes | osteomalacia | MESH:D010018 |
| 667 | 1903-1930 | Disease | denotes | gastrointestinal infections | MESH:D005767 |
| 680 | 2422-2426 | Gene | denotes | CD14 | Gene:929 |
| 681 | 2191-2196 | Species | denotes | human | Tax:9606 |
| 682 | 2857-2866 | Species | denotes | SARS-CoV2 | Tax:2697049 |
| 683 | 2292-2303 | Species | denotes | respiratory | Tax:12814 |
| 684 | 2826-2837 | Species | denotes | respiratory | Tax:12814 |
| 685 | 1998-2007 | Chemical | denotes | vitamin D | MESH:D014807 |
| 686 | 2095-2104 | Chemical | denotes | vitamin D | MESH:D014807 |
| 687 | 2334-2343 | Chemical | denotes | Vitamin D | MESH:D014807 |
| 688 | 2662-2671 | Chemical | denotes | vitamin D | MESH:D014807 |
| 689 | 2989-2998 | Chemical | denotes | vitamin D | MESH:D014807 |
| 690 | 2885-2901 | Disease | denotes | hypercytokinemia | |
| 691 | 3049-3064 | Disease | denotes | viral infection | MESH:D001102 |
| 705 | 3121-3129 | Gene | denotes | IFN-beta | Gene:3440 |
| 706 | 3131-3154 | Gene | denotes | tumor necrosis factor ( | Gene:7124 |
| 707 | 3154-3157 | Gene | denotes | TNF | Gene:7124 |
| 708 | 3165-3169 | Gene | denotes | IL-8 | Gene:3576 |
| 709 | 3174-3178 | Gene | denotes | IL-6 | Gene:3569 |
| 710 | 3439-3448 | Gene | denotes | IFN gamma | Gene:3458 |
| 711 | 3541-3546 | Gene | denotes | MKP-1 | Gene:1843 |
| 712 | 3684-3687 | Gene | denotes | TNF | Gene:7124 |
| 713 | 3235-3244 | Chemical | denotes | vitamin D | MESH:D014807 |
| 714 | 3394-3403 | Chemical | denotes | Vitamin D | MESH:D014807 |
| 715 | 3106-3115 | Disease | denotes | infection | MESH:D007239 |
| 716 | 3262-3271 | Disease | denotes | infection | MESH:D007239 |
| 717 | 3370-3386 | Disease | denotes | Dengue infection | MESH:D003715 |
| 724 | 3753-3758 | Gene | denotes | FOXP3 | Gene:50943 |
| 725 | 3833-3838 | Gene | denotes | FOXP3 | Gene:50943 |
| 726 | 3970-3975 | Gene | denotes | IL-10 | Gene:3586 |
| 727 | 3725-3734 | Chemical | denotes | Vitamin D | MESH:D014807 |
| 728 | 4080-4089 | Chemical | denotes | vitamin D | MESH:D014807 |
| 729 | 4159-4164 | Chemical | denotes | Tregs |