PMC:7589163 / 23241-23815 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T152","span":{"begin":70,"end":75},"obj":"Body_part"},{"id":"T153","span":{"begin":90,"end":94},"obj":"Body_part"},{"id":"T154","span":{"begin":180,"end":185},"obj":"Body_part"},{"id":"T155","span":{"begin":238,"end":242},"obj":"Body_part"},{"id":"T156","span":{"begin":258,"end":262},"obj":"Body_part"},{"id":"T157","span":{"begin":363,"end":380},"obj":"Body_part"},{"id":"T158","span":{"begin":443,"end":448},"obj":"Body_part"}],"attributes":[{"id":"A152","pred":"fma_id","subj":"T152","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A155","pred":"fma_id","subj":"T155","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A156","pred":"fma_id","subj":"T156","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A157","pred":"fma_id","subj":"T157","obj":"http://purl.org/sig/ont/fma/fma265130"},{"id":"A158","pred":"fma_id","subj":"T158","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Recently, Diao et al. retrospectively reviewed the numbers of total T cells, CD4+, CD8+ T cell subsets in a total of 499 COVID-19 patients and found a significantly reduction of T cells counts. Furthermore, they demonstrated a state of T cell dysfunction (T cell exhaustion) following SARS-CoV-2 infection [73]. Thus, the possibility that vitamin C affects viral respiratory tract infections, also supporting the viral clearance mediated by T cells, could encourage further studies aimed to investigate the role of vitamin C for prevention and treatment of COVID-19 disease."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T54","span":{"begin":363,"end":380},"obj":"Body_part"}],"attributes":[{"id":"A54","pred":"uberon_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/UBERON_0000065"}],"text":"Recently, Diao et al. retrospectively reviewed the numbers of total T cells, CD4+, CD8+ T cell subsets in a total of 499 COVID-19 patients and found a significantly reduction of T cells counts. Furthermore, they demonstrated a state of T cell dysfunction (T cell exhaustion) following SARS-CoV-2 infection [73]. Thus, the possibility that vitamin C affects viral respiratory tract infections, also supporting the viral clearance mediated by T cells, could encourage further studies aimed to investigate the role of vitamin C for prevention and treatment of COVID-19 disease."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T101","span":{"begin":121,"end":129},"obj":"Disease"},{"id":"T102","span":{"begin":285,"end":293},"obj":"Disease"},{"id":"T103","span":{"begin":296,"end":305},"obj":"Disease"},{"id":"T104","span":{"begin":357,"end":391},"obj":"Disease"},{"id":"T105","span":{"begin":557,"end":565},"obj":"Disease"}],"attributes":[{"id":"A101","pred":"mondo_id","subj":"T101","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A102","pred":"mondo_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A103","pred":"mondo_id","subj":"T103","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A104","pred":"mondo_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/MONDO_0024352"},{"id":"A105","pred":"mondo_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Recently, Diao et al. retrospectively reviewed the numbers of total T cells, CD4+, CD8+ T cell subsets in a total of 499 COVID-19 patients and found a significantly reduction of T cells counts. Furthermore, they demonstrated a state of T cell dysfunction (T cell exhaustion) following SARS-CoV-2 infection [73]. Thus, the possibility that vitamin C affects viral respiratory tract infections, also supporting the viral clearance mediated by T cells, could encourage further studies aimed to investigate the role of vitamin C for prevention and treatment of COVID-19 disease."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T262","span":{"begin":68,"end":75},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T263","span":{"begin":77,"end":80},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T264","span":{"begin":83,"end":86},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T265","span":{"begin":88,"end":94},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T266","span":{"begin":106,"end":107},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T267","span":{"begin":149,"end":150},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T268","span":{"begin":178,"end":185},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T269","span":{"begin":225,"end":226},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T270","span":{"begin":236,"end":242},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T271","span":{"begin":256,"end":262},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T272","span":{"begin":441,"end":448},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"Recently, Diao et al. retrospectively reviewed the numbers of total T cells, CD4+, CD8+ T cell subsets in a total of 499 COVID-19 patients and found a significantly reduction of T cells counts. Furthermore, they demonstrated a state of T cell dysfunction (T cell exhaustion) following SARS-CoV-2 infection [73]. Thus, the possibility that vitamin C affects viral respiratory tract infections, also supporting the viral clearance mediated by T cells, could encourage further studies aimed to investigate the role of vitamin C for prevention and treatment of COVID-19 disease."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T376","span":{"begin":339,"end":348},"obj":"Chemical"},{"id":"T377","span":{"begin":339,"end":346},"obj":"Chemical"},{"id":"T378","span":{"begin":515,"end":524},"obj":"Chemical"},{"id":"T379","span":{"begin":515,"end":522},"obj":"Chemical"}],"attributes":[{"id":"A376","pred":"chebi_id","subj":"T376","obj":"http://purl.obolibrary.org/obo/CHEBI_21241"},{"id":"A377","pred":"chebi_id","subj":"T377","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"},{"id":"A378","pred":"chebi_id","subj":"T378","obj":"http://purl.obolibrary.org/obo/CHEBI_21241"},{"id":"A379","pred":"chebi_id","subj":"T379","obj":"http://purl.obolibrary.org/obo/CHEBI_33229"}],"text":"Recently, Diao et al. retrospectively reviewed the numbers of total T cells, CD4+, CD8+ T cell subsets in a total of 499 COVID-19 patients and found a significantly reduction of T cells counts. Furthermore, they demonstrated a state of T cell dysfunction (T cell exhaustion) following SARS-CoV-2 infection [73]. Thus, the possibility that vitamin C affects viral respiratory tract infections, also supporting the viral clearance mediated by T cells, could encourage further studies aimed to investigate the role of vitamin C for prevention and treatment of COVID-19 disease."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T46","span":{"begin":236,"end":254},"obj":"Phenotype"},{"id":"T47","span":{"begin":363,"end":391},"obj":"Phenotype"}],"attributes":[{"id":"A46","pred":"hp_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/HP_0005435"},{"id":"A47","pred":"hp_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/HP_0011947"}],"text":"Recently, Diao et al. retrospectively reviewed the numbers of total T cells, CD4+, CD8+ T cell subsets in a total of 499 COVID-19 patients and found a significantly reduction of T cells counts. Furthermore, they demonstrated a state of T cell dysfunction (T cell exhaustion) following SARS-CoV-2 infection [73]. Thus, the possibility that vitamin C affects viral respiratory tract infections, also supporting the viral clearance mediated by T cells, could encourage further studies aimed to investigate the role of vitamin C for prevention and treatment of COVID-19 disease."}

{"project":"LitCovid-sentences","denotations":[{"id":"T159","span":{"begin":0,"end":193},"obj":"Sentence"},{"id":"T160","span":{"begin":194,"end":311},"obj":"Sentence"},{"id":"T161","span":{"begin":312,"end":574},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Recently, Diao et al. retrospectively reviewed the numbers of total T cells, CD4+, CD8+ T cell subsets in a total of 499 COVID-19 patients and found a significantly reduction of T cells counts. Furthermore, they demonstrated a state of T cell dysfunction (T cell exhaustion) following SARS-CoV-2 infection [73]. Thus, the possibility that vitamin C affects viral respiratory tract infections, also supporting the viral clearance mediated by T cells, could encourage further studies aimed to investigate the role of vitamin C for prevention and treatment of COVID-19 disease."}

{"project":"LitCovid-PubTator","denotations":[{"id":"600","span":{"begin":77,"end":80},"obj":"Gene"},{"id":"601","span":{"begin":83,"end":86},"obj":"Gene"},{"id":"602","span":{"begin":130,"end":138},"obj":"Species"},{"id":"603","span":{"begin":339,"end":348},"obj":"Chemical"},{"id":"604","span":{"begin":515,"end":524},"obj":"Chemical"},{"id":"605","span":{"begin":121,"end":129},"obj":"Disease"},{"id":"606","span":{"begin":236,"end":254},"obj":"Disease"},{"id":"607","span":{"begin":290,"end":305},"obj":"Disease"},{"id":"608","span":{"begin":363,"end":391},"obj":"Disease"},{"id":"609","span":{"begin":557,"end":565},"obj":"Disease"}],"attributes":[{"id":"A600","pred":"tao:has_database_id","subj":"600","obj":"Gene:920"},{"id":"A601","pred":"tao:has_database_id","subj":"601","obj":"Gene:925"},{"id":"A602","pred":"tao:has_database_id","subj":"602","obj":"Tax:9606"},{"id":"A603","pred":"tao:has_database_id","subj":"603","obj":"MESH:D001205"},{"id":"A604","pred":"tao:has_database_id","subj":"604","obj":"MESH:D001205"},{"id":"A605","pred":"tao:has_database_id","subj":"605","obj":"MESH:C000657245"},{"id":"A606","pred":"tao:has_database_id","subj":"606","obj":"MESH:C536780"},{"id":"A607","pred":"tao:has_database_id","subj":"607","obj":"MESH:C000657245"},{"id":"A608","pred":"tao:has_database_id","subj":"608","obj":"MESH:D012141"},{"id":"A609","pred":"tao:has_database_id","subj":"609","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Recently, Diao et al. retrospectively reviewed the numbers of total T cells, CD4+, CD8+ T cell subsets in a total of 499 COVID-19 patients and found a significantly reduction of T cells counts. Furthermore, they demonstrated a state of T cell dysfunction (T cell exhaustion) following SARS-CoV-2 infection [73]. Thus, the possibility that vitamin C affects viral respiratory tract infections, also supporting the viral clearance mediated by T cells, could encourage further studies aimed to investigate the role of vitamin C for prevention and treatment of COVID-19 disease."}