PMC:7589163 / 17982-19432
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T119 | 84-88 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T120 | 149-154 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T121 | 164-175 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T122 | 336-347 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T123 | 375-386 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T124 | 438-444 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T125 | 478-489 | Body_part | denotes | lymphocytes | http://purl.org/sig/ont/fma/fma62863 |
| T126 | 584-589 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T127 | 609-613 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T128 | 661-669 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T129 | 706-710 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T130 | 851-860 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T131 | 876-880 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T132 | 971-979 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T133 | 992-995 | Body_part | denotes | IgM | http://purl.org/sig/ont/fma/fma62873 |
| T134 | 1000-1003 | Body_part | denotes | IgG | http://purl.org/sig/ont/fma/fma62872 |
| T135 | 1134-1139 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T136 | 1140-1151 | Body_part | denotes | lymphocytes | http://purl.org/sig/ont/fma/fma62863 |
| T137 | 1229-1233 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T138 | 1324-1328 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T139 | 1420-1427 | Body_part | denotes | histone | http://purl.org/sig/ont/fma/fma74413 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T45 | 438-444 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T46 | 1134-1139 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T73 | 362-371 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T220 | 84-88 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T221 | 138-148 | http://purl.obolibrary.org/obo/CL_0000234 | denotes | phagocytic |
| T222 | 149-154 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T223 | 512-515 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T224 | 575-576 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T225 | 582-589 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cells |
| T226 | 609-613 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T227 | 706-715 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cell type |
| T228 | 767-770 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T229 | 1008-1014 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
| T230 | 1067-1068 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T231 | 1134-1139 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T232 | 1134-1139 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T233 | 1227-1233 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cell |
| T234 | 1322-1328 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cell |
| T235 | 1383-1386 | http://purl.obolibrary.org/obo/CLO_0050884 | denotes | ten |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T282 | 13-22 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T283 | 13-20 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T284 | 113-122 | Chemical | denotes | Vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290 |
| T287 | 113-120 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T288 | 233-236 | Chemical | denotes | ROS | http://purl.obolibrary.org/obo/CHEBI_26523 |
| T289 | 465-474 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T290 | 465-472 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T291 | 648-657 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T292 | 648-655 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T293 | 786-795 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T294 | 786-793 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T295 | 866-868 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T297 | 876-878 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T299 | 918-931 | Chemical | denotes | ascorbic acid | http://purl.obolibrary.org/obo/CHEBI_22652|http://purl.obolibrary.org/obo/CHEBI_29073 |
| T301 | 927-931 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T302 | 1042-1055 | Chemical | denotes | ascorbic acid | http://purl.obolibrary.org/obo/CHEBI_22652|http://purl.obolibrary.org/obo/CHEBI_29073 |
| T304 | 1051-1055 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T305 | 1204-1213 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T306 | 1204-1211 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T307 | 1298-1307 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T308 | 1298-1305 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T309 | 1420-1427 | Chemical | denotes | histone | http://purl.obolibrary.org/obo/CHEBI_15358 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T65 | 84-106 | http://purl.obolibrary.org/obo/GO_0002456 | denotes | cell-mediated immunity |
| T66 | 84-106 | http://purl.obolibrary.org/obo/GO_0002449 | denotes | cell-mediated immunity |
| T67 | 193-203 | http://purl.obolibrary.org/obo/GO_0006935 | denotes | chemotaxis |
| T68 | 205-217 | http://purl.obolibrary.org/obo/GO_0006909 | denotes | phagocytosis |
| T69 | 299-308 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T70 | 299-308 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T71 | 407-415 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T72 | 407-415 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T73 | 407-415 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T74 | 407-415 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T75 | 817-826 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T76 | 971-990 | http://purl.obolibrary.org/obo/GO_0002377 | denotes | antibody production |
| T77 | 1104-1119 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T78 | 1229-1244 | http://purl.obolibrary.org/obo/GO_0048469 | denotes | cell maturation |
| T79 | 1324-1339 | http://purl.obolibrary.org/obo/GO_0048469 | denotes | cell maturation |
| T80 | 1420-1441 | http://purl.obolibrary.org/obo/GO_0016577 | denotes | histone demethylation |
| T81 | 1428-1441 | http://purl.obolibrary.org/obo/GO_0070988 | denotes | demethylation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T124 | 0-112 | Sentence | denotes | Furthermore, vitamin C is effective in supporting both the humoral response and the cell-mediated immunity [46]. |
| T125 | 113-276 | Sentence | denotes | Vitamin C accumulates in phagocytic cells, such as neutrophils, and can enhance chemotaxis, phagocytosis, generation of ROS, and ultimately microbial killing [57]. |
| T126 | 277-452 | Sentence | denotes | It is also needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage. |
| T127 | 453-633 | Sentence | denotes | The role of vitamin C in lymphocytes is less clear, but it has been shown to enhance differentiation and proliferation of B- and T-cells, likely due to its gene-regulating effects. |
| T128 | 634-750 | Sentence | denotes | The effect of vitamin C on cytokine generation appears to depend on the cell type and/or the inflammatory stimulant. |
| T129 | 751-887 | Sentence | denotes | Recent research has indicated that vitamin C treatment attenuates synthesis of the pro-inflammatory cytokines TNF, IL-6, and IL-1β [57]. |
| T130 | 888-1157 | Sentence | denotes | In vitro studies suggest that ascorbic acid operates as potent immunostimulator of antibody production (IgM and IgG) in humans and that the intracellular ascorbic acid content is a key parameter for establishing the immune response of peripheral blood lymphocytes [58]. |
| T131 | 1158-1250 | Sentence | denotes | Other in vitro studies have shown the role of vitamin C in promoting T-cell maturation [59]. |
| T132 | 1251-1450 | Sentence | denotes | Recent research indicates the possible role of vitamin C in regulating T-cell maturation via epigenetic mechanisms involving in the ten-eleven translocations (TETs) and histone demethylation [60,61]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 441 | 861-864 | Gene | denotes | TNF | Gene:7124 |
| 442 | 866-870 | Gene | denotes | IL-6 | Gene:3569 |
| 443 | 876-881 | Gene | denotes | IL-1β | Gene:3552 |
| 444 | 1008-1014 | Species | denotes | humans | Tax:9606 |
| 445 | 13-22 | Chemical | denotes | vitamin C | MESH:D001205 |
| 446 | 113-122 | Chemical | denotes | Vitamin C | MESH:D001205 |
| 447 | 233-236 | Chemical | denotes | ROS | MESH:D017382 |
| 448 | 465-474 | Chemical | denotes | vitamin C | MESH:D001205 |
| 449 | 648-657 | Chemical | denotes | vitamin C | MESH:D001205 |
| 450 | 786-795 | Chemical | denotes | vitamin C | MESH:D001205 |
| 451 | 918-931 | Chemical | denotes | ascorbic acid | MESH:D001205 |
| 452 | 1042-1055 | Chemical | denotes | ascorbic acid | MESH:D001205 |
| 453 | 1204-1213 | Chemical | denotes | vitamin C | MESH:D001205 |
| 454 | 1298-1307 | Chemical | denotes | vitamin C | MESH:D001205 |
| 455 | 362-371 | Disease | denotes | infection | MESH:D007239 |
| 456 | 407-415 | Disease | denotes | necrosis | MESH:D009336 |
| 457 | 416-423 | Disease | denotes | NETosis |