PMC:7589163 / 1741-3203 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T9","span":{"begin":4,"end":17},"obj":"Body_part"},{"id":"T10","span":{"begin":30,"end":34},"obj":"Body_part"},{"id":"T11","span":{"begin":197,"end":201},"obj":"Body_part"},{"id":"T12","span":{"begin":203,"end":219},"obj":"Body_part"},{"id":"T13","span":{"begin":250,"end":266},"obj":"Body_part"},{"id":"T14","span":{"begin":261,"end":266},"obj":"Body_part"},{"id":"T15","span":{"begin":315,"end":328},"obj":"Body_part"},{"id":"T16","span":{"begin":366,"end":370},"obj":"Body_part"},{"id":"T17","span":{"begin":409,"end":422},"obj":"Body_part"},{"id":"T18","span":{"begin":820,"end":824},"obj":"Body_part"},{"id":"T19","span":{"begin":866,"end":875},"obj":"Body_part"},{"id":"T20","span":{"begin":941,"end":949},"obj":"Body_part"},{"id":"T21","span":{"begin":1089,"end":1094},"obj":"Body_part"},{"id":"T22","span":{"begin":1102,"end":1107},"obj":"Body_part"},{"id":"T23","span":{"begin":1276,"end":1281},"obj":"Body_part"}],"attributes":[{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma7163"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma85355"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"The immune system defends the body against infectious agents and other internal and external insults. The immune defense system comprises a combination of anatomic physical barriers, including the skin, mucous membranes, mucous blanket, and ciliated epithelial cells [1]. If these are evaded, the components of the immune system are quickly activated to protect the body against any “non-self” molecules. The immune system integrates two fundamental response mechanisms: the innate response and the acquired one. Innate responses occur to the same extent however many times the infectious agent is encountered. Innate immunity is rapid and utilizes receptors (pattern recognition receptors, PRRs) to recognize the invading particles, known as pathogen-associated molecular patterns (PAMPs). The innate defenses comprise cell-intrinsic responses to viral infections, leukocyte responses to pathogens, and soluble mediators such as complement proteins. Innate immunity is an immediate defense that is not as specific or mutable as antigen receptors. Adaptive immunity is specific to T and B cells. These cells recognize specific antigens on the invading microorganism and produce antibodies to target and destroy the pathogen, enabling identification for attack by other immune cells or neutralizing the pathogen directly. The adaptive immunity generates the immunological memory; thus, acquired responses improve on repeated exposure to a given infection [2,3,4]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T4","span":{"begin":4,"end":17},"obj":"Body_part"},{"id":"T5","span":{"begin":197,"end":201},"obj":"Body_part"},{"id":"T6","span":{"begin":203,"end":219},"obj":"Body_part"},{"id":"T7","span":{"begin":315,"end":328},"obj":"Body_part"},{"id":"T8","span":{"begin":409,"end":422},"obj":"Body_part"}],"attributes":[{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000344"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"The immune system defends the body against infectious agents and other internal and external insults. The immune defense system comprises a combination of anatomic physical barriers, including the skin, mucous membranes, mucous blanket, and ciliated epithelial cells [1]. If these are evaded, the components of the immune system are quickly activated to protect the body against any “non-self” molecules. The immune system integrates two fundamental response mechanisms: the innate response and the acquired one. Innate responses occur to the same extent however many times the infectious agent is encountered. Innate immunity is rapid and utilizes receptors (pattern recognition receptors, PRRs) to recognize the invading particles, known as pathogen-associated molecular patterns (PAMPs). The innate defenses comprise cell-intrinsic responses to viral infections, leukocyte responses to pathogens, and soluble mediators such as complement proteins. Innate immunity is an immediate defense that is not as specific or mutable as antigen receptors. Adaptive immunity is specific to T and B cells. These cells recognize specific antigens on the invading microorganism and produce antibodies to target and destroy the pathogen, enabling identification for attack by other immune cells or neutralizing the pathogen directly. The adaptive immunity generates the immunological memory; thus, acquired responses improve on repeated exposure to a given infection [2,3,4]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T10","span":{"begin":43,"end":53},"obj":"Disease"},{"id":"T11","span":{"begin":578,"end":588},"obj":"Disease"},{"id":"T12","span":{"begin":848,"end":864},"obj":"Disease"},{"id":"T13","span":{"begin":1444,"end":1453},"obj":"Disease"}],"attributes":[{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"The immune system defends the body against infectious agents and other internal and external insults. The immune defense system comprises a combination of anatomic physical barriers, including the skin, mucous membranes, mucous blanket, and ciliated epithelial cells [1]. If these are evaded, the components of the immune system are quickly activated to protect the body against any “non-self” molecules. The immune system integrates two fundamental response mechanisms: the innate response and the acquired one. Innate responses occur to the same extent however many times the infectious agent is encountered. Innate immunity is rapid and utilizes receptors (pattern recognition receptors, PRRs) to recognize the invading particles, known as pathogen-associated molecular patterns (PAMPs). The innate defenses comprise cell-intrinsic responses to viral infections, leukocyte responses to pathogens, and soluble mediators such as complement proteins. Innate immunity is an immediate defense that is not as specific or mutable as antigen receptors. Adaptive immunity is specific to T and B cells. These cells recognize specific antigens on the invading microorganism and produce antibodies to target and destroy the pathogen, enabling identification for attack by other immune cells or neutralizing the pathogen directly. The adaptive immunity generates the immunological memory; thus, acquired responses improve on repeated exposure to a given infection [2,3,4]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T12","span":{"begin":4,"end":17},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T13","span":{"begin":138,"end":139},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T14","span":{"begin":197,"end":201},"obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"T15","span":{"begin":197,"end":201},"obj":"http://purl.obolibrary.org/obo/UBERON_0001003"},{"id":"T16","span":{"begin":197,"end":201},"obj":"http://purl.obolibrary.org/obo/UBERON_0002097"},{"id":"T17","span":{"begin":197,"end":201},"obj":"http://purl.obolibrary.org/obo/UBERON_0002199"},{"id":"T18","span":{"begin":197,"end":201},"obj":"http://www.ebi.ac.uk/efo/EFO_0000962"},{"id":"T19","span":{"begin":203,"end":219},"obj":"http://purl.obolibrary.org/obo/UBERON_0000344"},{"id":"T20","span":{"begin":250,"end":260},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T21","span":{"begin":261,"end":266},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T22","span":{"begin":315,"end":328},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T23","span":{"begin":341,"end":350},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T24","span":{"begin":409,"end":422},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T25","span":{"begin":820,"end":824},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T26","span":{"begin":1087,"end":1094},"obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"T27","span":{"begin":1102,"end":1107},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T28","span":{"begin":1276,"end":1281},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T29","span":{"begin":1436,"end":1437},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The immune system defends the body against infectious agents and other internal and external insults. The immune defense system comprises a combination of anatomic physical barriers, including the skin, mucous membranes, mucous blanket, and ciliated epithelial cells [1]. If these are evaded, the components of the immune system are quickly activated to protect the body against any “non-self” molecules. The immune system integrates two fundamental response mechanisms: the innate response and the acquired one. Innate responses occur to the same extent however many times the infectious agent is encountered. Innate immunity is rapid and utilizes receptors (pattern recognition receptors, PRRs) to recognize the invading particles, known as pathogen-associated molecular patterns (PAMPs). The innate defenses comprise cell-intrinsic responses to viral infections, leukocyte responses to pathogens, and soluble mediators such as complement proteins. Innate immunity is an immediate defense that is not as specific or mutable as antigen receptors. Adaptive immunity is specific to T and B cells. These cells recognize specific antigens on the invading microorganism and produce antibodies to target and destroy the pathogen, enabling identification for attack by other immune cells or neutralizing the pathogen directly. The adaptive immunity generates the immunological memory; thus, acquired responses improve on repeated exposure to a given infection [2,3,4]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T23","span":{"begin":394,"end":403},"obj":"Chemical"},{"id":"T24","span":{"begin":941,"end":949},"obj":"Chemical"},{"id":"T25","span":{"begin":1029,"end":1036},"obj":"Chemical"},{"id":"T26","span":{"begin":1127,"end":1135},"obj":"Chemical"}],"attributes":[{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A26","pred":"chebi_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"}],"text":"The immune system defends the body against infectious agents and other internal and external insults. The immune defense system comprises a combination of anatomic physical barriers, including the skin, mucous membranes, mucous blanket, and ciliated epithelial cells [1]. If these are evaded, the components of the immune system are quickly activated to protect the body against any “non-self” molecules. The immune system integrates two fundamental response mechanisms: the innate response and the acquired one. Innate responses occur to the same extent however many times the infectious agent is encountered. Innate immunity is rapid and utilizes receptors (pattern recognition receptors, PRRs) to recognize the invading particles, known as pathogen-associated molecular patterns (PAMPs). The innate defenses comprise cell-intrinsic responses to viral infections, leukocyte responses to pathogens, and soluble mediators such as complement proteins. Innate immunity is an immediate defense that is not as specific or mutable as antigen receptors. Adaptive immunity is specific to T and B cells. These cells recognize specific antigens on the invading microorganism and produce antibodies to target and destroy the pathogen, enabling identification for attack by other immune cells or neutralizing the pathogen directly. The adaptive immunity generates the immunological memory; thus, acquired responses improve on repeated exposure to a given infection [2,3,4]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T5","span":{"begin":611,"end":626},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T6","span":{"begin":848,"end":864},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T7","span":{"begin":951,"end":966},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T8","span":{"begin":1371,"end":1377},"obj":"http://purl.obolibrary.org/obo/GO_0007613"}],"text":"The immune system defends the body against infectious agents and other internal and external insults. The immune defense system comprises a combination of anatomic physical barriers, including the skin, mucous membranes, mucous blanket, and ciliated epithelial cells [1]. If these are evaded, the components of the immune system are quickly activated to protect the body against any “non-self” molecules. The immune system integrates two fundamental response mechanisms: the innate response and the acquired one. Innate responses occur to the same extent however many times the infectious agent is encountered. Innate immunity is rapid and utilizes receptors (pattern recognition receptors, PRRs) to recognize the invading particles, known as pathogen-associated molecular patterns (PAMPs). The innate defenses comprise cell-intrinsic responses to viral infections, leukocyte responses to pathogens, and soluble mediators such as complement proteins. Innate immunity is an immediate defense that is not as specific or mutable as antigen receptors. Adaptive immunity is specific to T and B cells. These cells recognize specific antigens on the invading microorganism and produce antibodies to target and destroy the pathogen, enabling identification for attack by other immune cells or neutralizing the pathogen directly. The adaptive immunity generates the immunological memory; thus, acquired responses improve on repeated exposure to a given infection [2,3,4]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T14","span":{"begin":0,"end":101},"obj":"Sentence"},{"id":"T15","span":{"begin":102,"end":271},"obj":"Sentence"},{"id":"T16","span":{"begin":272,"end":404},"obj":"Sentence"},{"id":"T17","span":{"begin":405,"end":512},"obj":"Sentence"},{"id":"T18","span":{"begin":513,"end":610},"obj":"Sentence"},{"id":"T19","span":{"begin":611,"end":790},"obj":"Sentence"},{"id":"T20","span":{"begin":791,"end":950},"obj":"Sentence"},{"id":"T21","span":{"begin":951,"end":1047},"obj":"Sentence"},{"id":"T22","span":{"begin":1048,"end":1095},"obj":"Sentence"},{"id":"T23","span":{"begin":1096,"end":1320},"obj":"Sentence"},{"id":"T24","span":{"begin":1321,"end":1462},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The immune system defends the body against infectious agents and other internal and external insults. The immune defense system comprises a combination of anatomic physical barriers, including the skin, mucous membranes, mucous blanket, and ciliated epithelial cells [1]. If these are evaded, the components of the immune system are quickly activated to protect the body against any “non-self” molecules. The immune system integrates two fundamental response mechanisms: the innate response and the acquired one. Innate responses occur to the same extent however many times the infectious agent is encountered. Innate immunity is rapid and utilizes receptors (pattern recognition receptors, PRRs) to recognize the invading particles, known as pathogen-associated molecular patterns (PAMPs). The innate defenses comprise cell-intrinsic responses to viral infections, leukocyte responses to pathogens, and soluble mediators such as complement proteins. Innate immunity is an immediate defense that is not as specific or mutable as antigen receptors. Adaptive immunity is specific to T and B cells. These cells recognize specific antigens on the invading microorganism and produce antibodies to target and destroy the pathogen, enabling identification for attack by other immune cells or neutralizing the pathogen directly. The adaptive immunity generates the immunological memory; thus, acquired responses improve on repeated exposure to a given infection [2,3,4]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"32","span":{"begin":848,"end":864},"obj":"Disease"},{"id":"33","span":{"begin":1444,"end":1453},"obj":"Disease"}],"attributes":[{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:D001102"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The immune system defends the body against infectious agents and other internal and external insults. The immune defense system comprises a combination of anatomic physical barriers, including the skin, mucous membranes, mucous blanket, and ciliated epithelial cells [1]. If these are evaded, the components of the immune system are quickly activated to protect the body against any “non-self” molecules. The immune system integrates two fundamental response mechanisms: the innate response and the acquired one. Innate responses occur to the same extent however many times the infectious agent is encountered. Innate immunity is rapid and utilizes receptors (pattern recognition receptors, PRRs) to recognize the invading particles, known as pathogen-associated molecular patterns (PAMPs). The innate defenses comprise cell-intrinsic responses to viral infections, leukocyte responses to pathogens, and soluble mediators such as complement proteins. Innate immunity is an immediate defense that is not as specific or mutable as antigen receptors. Adaptive immunity is specific to T and B cells. These cells recognize specific antigens on the invading microorganism and produce antibodies to target and destroy the pathogen, enabling identification for attack by other immune cells or neutralizing the pathogen directly. The adaptive immunity generates the immunological memory; thus, acquired responses improve on repeated exposure to a given infection [2,3,4]."}