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PMC:7589163 / 14783-23815 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T94 395-401 Body_part denotes Breast http://purl.org/sig/ont/fma/fma9601
T95 402-406 Body_part denotes milk http://purl.org/sig/ont/fma/fma62100
T96 587-595 Body_part denotes collagen http://purl.org/sig/ont/fma/fma63891
T97 597-613 Body_part denotes neurotransmitter http://purl.org/sig/ont/fma/fma302832
T98 650-660 Body_part denotes fatty acid http://purl.org/sig/ont/fma/fma82738
T99 881-901 Body_part denotes hematopoietic system http://purl.org/sig/ont/fma/fma9667
T100 1130-1143 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T101 1180-1189 Body_part denotes leukocyte http://purl.org/sig/ont/fma/fma62852
T102 1283-1288 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T103 1298-1308 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T104 1402-1406 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T105 1415-1425 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T106 1548-1553 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T107 1577-1582 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T108 1807-1811 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T109 2003-2013 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T110 2185-2195 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T111 2260-2268 Body_part denotes neonates http://purl.org/sig/ont/fma/fma292381
T112 2611-2622 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T113 2690-2701 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T114 2768-2774 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T115 2934-2945 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T116 2972-2982 Body_part denotes neutrophil http://purl.org/sig/ont/fma/fma62860
T117 3102-3113 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T118 3148-3154 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T119 3283-3287 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T120 3348-3353 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T121 3363-3374 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T122 3535-3546 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T123 3574-3585 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T124 3637-3643 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T125 3677-3688 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T126 3783-3788 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T127 3808-3812 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T128 3860-3868 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T129 3905-3909 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T130 4050-4059 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T131 4075-4079 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T132 4170-4178 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T133 4191-4194 Body_part denotes IgM http://purl.org/sig/ont/fma/fma62873
T134 4199-4202 Body_part denotes IgG http://purl.org/sig/ont/fma/fma62872
T135 4333-4338 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T136 4339-4350 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T137 4428-4432 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T138 4523-4527 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T139 4619-4626 Body_part denotes histone http://purl.org/sig/ont/fma/fma74413
T140 4680-4686 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T141 4725-4731 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T142 4877-4883 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T143 4991-4995 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T144 5126-5136 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T145 5168-5173 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T146 5553-5559 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T147 6420-6426 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T148 6960-6983 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T149 7333-7356 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T150 7456-7479 Body_part denotes lower respiratory tract http://purl.org/sig/ont/fma/fma45662
T151 8313-8318 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T152 8528-8533 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T153 8548-8552 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T154 8638-8643 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T155 8696-8700 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T156 8716-8720 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T157 8821-8838 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T158 8901-8906 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T38 395-401 Body_part denotes Breast http://purl.obolibrary.org/obo/UBERON_0000310
T39 402-406 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T40 881-901 Body_part denotes hematopoietic system http://purl.obolibrary.org/obo/UBERON_0002390
T41 1130-1143 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T42 1402-1406 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T43 2768-2774 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T44 3148-3154 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T45 3637-3643 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T46 4333-4338 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T47 6960-6983 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T48 6966-6983 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T49 7333-7356 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T50 7339-7356 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T51 7456-7479 Body_part denotes lower respiratory tract http://purl.obolibrary.org/obo/UBERON_0001558
T52 7462-7479 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T53 8313-8318 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T54 8821-8838 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T66 2319-2328 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T67 2347-2367 Disease denotes vitamin C deficiency http://purl.obolibrary.org/obo/MONDO_0009412
T68 2442-2452 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T69 2468-2486 Disease denotes genetic conditions http://purl.obolibrary.org/obo/MONDO_0003847
T70 2495-2519 Disease denotes Chediak–Higashi syndrome http://purl.obolibrary.org/obo/MONDO_0008963
T71 2521-2524 Disease denotes CHS http://purl.obolibrary.org/obo/MONDO_0008963
T72 2732-2744 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T73 3561-3570 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T74 4853-4859 Disease denotes Scurvy http://purl.obolibrary.org/obo/MONDO_0009412
T75 5099-5108 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T76 5868-5883 Disease denotes Viral Infection http://purl.obolibrary.org/obo/MONDO_0005108
T77 5874-5883 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T78 5884-5904 Disease denotes Vitamin C deficiency http://purl.obolibrary.org/obo/MONDO_0009412
T79 5969-5991 Disease denotes respiratory infections http://purl.obolibrary.org/obo/MONDO_0024355
T80 6000-6009 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T81 6163-6172 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T82 6270-6279 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T83 6372-6381 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T84 6509-6518 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T85 6793-6802 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T86 6960-6994 Disease denotes upper respiratory tract infections http://purl.obolibrary.org/obo/MONDO_0024355
T87 7008-7019 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T88 7150-7161 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T89 7339-7366 Disease denotes respiratory tract infection http://purl.obolibrary.org/obo/MONDO_0024355
T90 7357-7366 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T91 7462-7489 Disease denotes respiratory tract infection http://purl.obolibrary.org/obo/MONDO_0024355
T92 7480-7489 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T93 7631-7642 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T94 7760-7771 Disease denotes common cold http://purl.obolibrary.org/obo/MONDO_0005709
T95 7787-7795 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T96 7884-7899 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T97 7890-7899 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T98 7910-7918 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T99 8074-8083 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T100 8269-8273 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T101 8579-8587 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T102 8743-8751 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T103 8754-8763 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T104 8815-8849 Disease denotes viral respiratory tract infections http://purl.obolibrary.org/obo/MONDO_0024352
T105 9015-9023 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T187 73-74 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T188 132-138 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T189 395-401 http://purl.obolibrary.org/obo/UBERON_0000310 denotes Breast
T190 587-595 http://purl.obolibrary.org/obo/CHEBI_3815 denotes collagen
T191 743-744 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T192 780-781 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T193 790-796 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T194 1130-1143 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T195 1200-1202 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T196 1232-1240 http://purl.obolibrary.org/obo/CLO_0001658 denotes actively
T197 1283-1288 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T198 1376-1377 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T199 1402-1406 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T200 1402-1406 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T201 1402-1406 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T202 1402-1406 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T203 1402-1406 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T204 1445-1446 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T205 1548-1553 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T206 1577-1582 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T207 1637-1639 http://purl.obolibrary.org/obo/CLO_0053799 denotes 45
T208 1654-1664 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytes
T209 1705-1712 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T210 1732-1740 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T211 1807-1811 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T212 1868-1877 http://purl.obolibrary.org/obo/SO_0000418 denotes signaling
T213 1886-1895 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T214 2024-2026 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T215 2108-2114 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T216 2310-2311 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T217 2599-2607 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T218 2886-2887 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T219 3194-3196 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T220 3283-3287 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T221 3337-3347 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytic
T222 3348-3353 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T223 3711-3714 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T224 3774-3775 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T225 3781-3788 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cells
T226 3808-3812 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T227 3905-3914 http://purl.obolibrary.org/obo/CL_0000000 denotes cell type
T228 3966-3969 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T229 4207-4213 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T230 4266-4267 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T231 4333-4338 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T232 4333-4338 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T233 4426-4432 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T234 4521-4527 http://purl.obolibrary.org/obo/CL_0000084 denotes T-cell
T235 4582-4585 http://purl.obolibrary.org/obo/CLO_0050884 denotes ten
T236 4680-4686 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T237 4725-4731 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T238 4803-4804 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T239 4877-4883 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T240 4989-4990 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T241 5168-5173 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T242 5325-5330 http://purl.obolibrary.org/obo/CLO_0002128 denotes C [44
T243 5533-5534 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T244 5553-5559 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T245 6059-6060 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T246 6244-6245 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T247 6420-6426 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T248 6903-6904 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T249 7021-7024 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T250 7212-7213 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T251 7276-7277 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T252 7456-7479 http://purl.obolibrary.org/obo/UBERON_0001558 denotes lower respiratory tract
T253 7496-7497 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T254 7629-7630 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T255 7688-7689 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T256 7758-7759 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T257 7827-7828 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T258 8065-8066 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T259 8116-8118 http://purl.obolibrary.org/obo/CLO_0054055 denotes 71
T260 8121-8122 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T261 8313-8318 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T262 8526-8533 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T263 8535-8538 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T264 8541-8544 http://purl.obolibrary.org/obo/CLO_0053438 denotes CD8
T265 8546-8552 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T266 8564-8565 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T267 8607-8608 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T268 8636-8643 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T269 8683-8684 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T270 8694-8700 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T271 8714-8720 http://purl.obolibrary.org/obo/CL_0000084 denotes T cell
T272 8899-8906 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T203 3-12 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T206 3-10 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T207 44-53 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T210 44-51 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T211 55-68 Chemical denotes ascorbic acid http://purl.obolibrary.org/obo/CHEBI_22652|http://purl.obolibrary.org/obo/CHEBI_29073
T213 64-68 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T214 75-96 Chemical denotes water-soluble vitamin http://purl.obolibrary.org/obo/CHEBI_27314
T215 75-80 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T216 89-96 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T217 114-127 Chemical denotes micronutrient http://purl.obolibrary.org/obo/CHEBI_27027
T218 160-169 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T219 160-167 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T220 261-270 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T221 261-268 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T222 440-449 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T223 440-447 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T224 476-489 Chemical denotes Ascorbic acid http://purl.obolibrary.org/obo/CHEBI_29073
T225 485-489 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T226 496-507 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T227 509-523 Chemical denotes electron donor http://purl.obolibrary.org/obo/CHEBI_15022|http://purl.obolibrary.org/obo/CHEBI_39144
T229 509-517 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T230 518-523 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T231 597-613 Chemical denotes neurotransmitter http://purl.obolibrary.org/obo/CHEBI_25512
T232 626-637 Chemical denotes cholesterol http://purl.obolibrary.org/obo/CHEBI_16113
T233 650-660 Chemical denotes fatty acid http://purl.obolibrary.org/obo/CHEBI_35366
T234 656-660 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T235 685-694 Chemical denotes carnitine http://purl.obolibrary.org/obo/CHEBI_17126
T236 713-717 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T237 722-728 Chemical denotes copper http://purl.obolibrary.org/obo/CHEBI_28694|http://purl.obolibrary.org/obo/CHEBI_30052
T239 729-734 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T240 745-753 Chemical denotes cofactor http://purl.obolibrary.org/obo/CHEBI_23357
T241 817-826 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T242 817-824 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T243 940-944 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T244 973-977 Chemical denotes iron http://purl.obolibrary.org/obo/CHEBI_18248
T245 1029-1049 Chemical denotes tetrahydrofolic acid http://purl.obolibrary.org/obo/CHEBI_20506|http://purl.obolibrary.org/obo/CHEBI_26907
T247 1045-1049 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T248 1056-1065 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T251 1056-1063 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T252 1082-1090 Chemical denotes nutrient http://purl.obolibrary.org/obo/CHEBI_33284
T253 1219-1228 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T254 1219-1226 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T255 1314-1320 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T256 1362-1369 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T257 1432-1441 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T260 1432-1439 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T261 1454-1459 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T262 1468-1479 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T263 1606-1629 Chemical denotes reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_26523
T264 1615-1621 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T265 1631-1634 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T266 1748-1752 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T267 1778-1781 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T268 1928-1937 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T271 1928-1935 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T272 2347-2356 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T273 2347-2354 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T274 2548-2557 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T275 2548-2555 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T276 2632-2645 Chemical denotes Ascorbic acid http://purl.obolibrary.org/obo/CHEBI_29073
T277 2641-2645 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T278 2849-2858 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T279 2849-2856 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T280 3120-3133 Chemical denotes Ascorbic acid http://purl.obolibrary.org/obo/CHEBI_29073
T281 3129-3133 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T282 3212-3221 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T283 3212-3219 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T284 3312-3321 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T287 3312-3319 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T288 3432-3435 Chemical denotes ROS http://purl.obolibrary.org/obo/CHEBI_26523
T289 3664-3673 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T290 3664-3671 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T291 3847-3856 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T292 3847-3854 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T293 3985-3994 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T294 3985-3992 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T295 4065-4067 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T297 4075-4077 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T299 4117-4130 Chemical denotes ascorbic acid http://purl.obolibrary.org/obo/CHEBI_22652|http://purl.obolibrary.org/obo/CHEBI_29073
T301 4126-4130 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T302 4241-4254 Chemical denotes ascorbic acid http://purl.obolibrary.org/obo/CHEBI_22652|http://purl.obolibrary.org/obo/CHEBI_29073
T304 4250-4254 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T305 4403-4412 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T306 4403-4410 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T307 4497-4506 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T308 4497-4504 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T309 4619-4626 Chemical denotes histone http://purl.obolibrary.org/obo/CHEBI_15358
T310 4656-4665 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T313 4656-4663 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T314 4687-4696 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T315 4687-4694 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T316 4732-4741 Chemical denotes ascorbate http://purl.obolibrary.org/obo/CHEBI_22651
T317 4971-4980 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T318 4971-4978 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T319 5048-5057 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T320 5048-5055 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T321 5317-5326 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T322 5317-5324 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T323 5425-5434 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T324 5425-5432 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T325 5511-5520 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T326 5511-5518 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T327 5543-5552 Chemical denotes ascorbate http://purl.obolibrary.org/obo/CHEBI_22651
T328 5742-5751 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T329 5742-5749 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T330 5776-5781 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T331 5791-5800 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T332 5791-5798 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T333 5834-5843 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T336 5834-5841 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T337 5884-5893 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T340 5884-5891 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T341 6126-6135 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T342 6126-6133 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T343 6287-6296 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T344 6287-6294 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T345 6338-6347 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T346 6338-6345 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T347 6427-6436 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T348 6427-6434 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T349 6487-6496 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T350 6487-6494 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T351 6604-6613 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T352 6604-6611 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T353 6614-6619 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T354 6772-6781 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T355 6772-6779 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T356 6918-6927 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T357 6918-6925 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T358 6947-6956 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T359 6947-6954 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T360 7062-7071 Chemical denotes Vitamin C http://purl.obolibrary.org/obo/CHEBI_21241|http://purl.obolibrary.org/obo/CHEBI_29073|http://purl.obolibrary.org/obo/CHEBI_38290
T363 7062-7069 Chemical denotes Vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T364 7529-7538 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T365 7529-7536 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T366 7603-7612 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T367 7603-7610 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T368 7806-7815 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T369 7806-7813 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T370 7957-7966 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T371 7957-7964 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T372 8024-8033 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T373 8024-8031 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T374 8209-8218 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T375 8209-8216 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T376 8797-8806 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T377 8797-8804 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229
T378 8973-8982 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T379 8973-8980 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T44 19-29 http://purl.obolibrary.org/obo/GO_0008152 denotes Metabolism
T45 348-355 http://purl.obolibrary.org/obo/GO_0051235 denotes storage
T46 574-583 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T47 597-624 http://purl.obolibrary.org/obo/GO_0042133 denotes neurotransmitter metabolism
T48 614-624 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T49 626-648 http://purl.obolibrary.org/obo/GO_0008203 denotes cholesterol metabolism
T50 638-648 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T51 650-670 http://purl.obolibrary.org/obo/GO_0015908 denotes fatty acid transport
T52 661-670 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T53 672-681 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T54 1016-1025 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T55 1331-1342 http://purl.obolibrary.org/obo/GO_0006810 denotes transporter
T56 1529-1540 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T57 1868-1885 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T58 1868-1877 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T59 1903-1918 http://purl.obolibrary.org/obo/GO_0045730 denotes oxidative burst
T60 1949-1964 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T61 2669-2686 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptotic process
T62 2732-2744 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T63 2959-2968 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T64 3175-3184 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T65 3283-3305 http://purl.obolibrary.org/obo/GO_0002456 denotes cell-mediated immunity
T66 3283-3305 http://purl.obolibrary.org/obo/GO_0002449 denotes cell-mediated immunity
T67 3392-3402 http://purl.obolibrary.org/obo/GO_0006935 denotes chemotaxis
T68 3404-3416 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T69 3498-3507 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T70 3498-3507 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T71 3606-3614 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T72 3606-3614 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T73 3606-3614 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T74 3606-3614 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T75 4016-4025 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T76 4170-4189 http://purl.obolibrary.org/obo/GO_0002377 denotes antibody production
T77 4303-4318 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T78 4428-4443 http://purl.obolibrary.org/obo/GO_0048469 denotes cell maturation
T79 4523-4538 http://purl.obolibrary.org/obo/GO_0048469 denotes cell maturation
T80 4619-4640 http://purl.obolibrary.org/obo/GO_0016577 denotes histone demethylation
T81 4627-4640 http://purl.obolibrary.org/obo/GO_0070988 denotes demethylation
T82 5868-5883 http://purl.obolibrary.org/obo/GO_0016032 denotes Viral Infection
T83 7884-7899 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T28 2312-2328 Phenotype denotes severe infection http://purl.obolibrary.org/obo/HP_0032169
T29 2347-2367 Phenotype denotes vitamin C deficiency http://purl.obolibrary.org/obo/HP_0100510
T30 2432-2452 Phenotype denotes recurrent infections http://purl.obolibrary.org/obo/HP_0002719
T31 4898-4903 Phenotype denotes falls http://purl.obolibrary.org/obo/HP_0002527
T32 5186-5202 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T33 5884-5904 Phenotype denotes Vitamin C deficiency http://purl.obolibrary.org/obo/HP_0100510
T34 5969-5991 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947
T35 6000-6009 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T36 6163-6172 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T37 6270-6279 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T38 6372-6381 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T39 6509-6518 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T40 6793-6802 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T41 6960-6994 Phenotype denotes upper respiratory tract infections http://purl.obolibrary.org/obo/HP_0002788
T42 7333-7366 Phenotype denotes upper respiratory tract infection http://purl.obolibrary.org/obo/HP_0002788
T43 7456-7489 Phenotype denotes lower respiratory tract infection http://purl.obolibrary.org/obo/HP_0002783
T44 8067-8083 Phenotype denotes severe infection http://purl.obolibrary.org/obo/HP_0032169
T45 8258-8264 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T46 8694-8712 Phenotype denotes T cell dysfunction http://purl.obolibrary.org/obo/HP_0005435
T47 8821-8849 Phenotype denotes respiratory tract infections http://purl.obolibrary.org/obo/HP_0011947

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T104 0-2 Sentence denotes 4.
T105 3-12 Sentence denotes Vitamin C
T106 14-18 Sentence denotes 4.1.
T107 19-43 Sentence denotes Metabolism and Functions
T108 44-139 Sentence denotes Vitamin C (ascorbic acid) is a water-soluble vitamin and an essential micronutrient for humans.
T109 140-235 Sentence denotes The main sources of vitamin C are citrus fruit, tomatoes, potatoes, and green leafy vegetables.
T110 236-394 Sentence denotes The provision of dietary vitamin C is dependent on food preparation because it is easily destroyed by prolonged storage, overcooking, and processing of foods.
T111 395-475 Sentence denotes Breast milk represents an adequate source of vitamin C for newborns and infants.
T112 476-803 Sentence denotes Ascorbic acid is an antioxidant (electron donor) and is involved in several biological processes: synthesis of collagen, neurotransmitter metabolism, cholesterol metabolism, fatty acid transport (synthesis of carnitine), maintaining the iron and copper atoms, and is a cofactor of the metalloenzymes, in a reduced active state.
T113 804-1055 Sentence denotes Furthermore, vitamin C affects the cellular and immunologic functions of the hematopoietic system, due to its role in enhancing nonheme iron absorption, the transfer of iron from transferrin to ferritin, and the formation of tetrahydrofolic acid [44].
T114 1056-1204 Sentence denotes Vitamin C is an essential nutrient that influences several aspects of the immune system, particularly barrier integrity and leukocyte function [45].
T115 1205-1431 Sentence denotes The fact that vitamin C is actively accumulated into the epidermal and dermal cells and into leukocytes, via sodium-dependent transporter, suggests that the vitamin plays a crucial role within the skin and the leukocytes [46].
T116 1432-1741 Sentence denotes Vitamin C is a potent water-soluble antioxidant and plays an important role in maintaining redox homeostasis within cells and in protecting host cells against the actions of reactive oxygen species (ROS) [45], released by phagocytes in order to lead to the deactivation of viruses and the killing of bacteria.
T117 1742-1927 Sentence denotes Thus, acid ascorbic as scavenger of ROS may both protect crucial cell structural components and modulate the pro-inflammatory signaling pathway activated by the oxidative burst [46,47].
T118 1928-2131 Sentence denotes Vitamin C influences innate immunity also by regulating several aspects of neutrophil function [48], particularly the chemotactic ability, as shown in several in vitro and in vivo animal studies [49,50].
T119 2132-2376 Sentence denotes Severe septic syndromes are associated with impaired neutrophil chemotactic ability [51], and studies conducted in children and neonates may suggest that it could be due also by a severe infection-induced status of vitamin C deficiency [52,53].
T120 2377-2631 Sentence denotes Furthermore, studies have shown that, in patients with recurrent infections or affected by genetic conditions such as Chediak–Higashi syndrome (CHS), supplementation with vitamin C improved significantly the antibacterial activity of neutrophils [54,55].
T121 2632-2787 Sentence denotes Ascorbic acid may also influence the apoptotic process of neutrophils, thus promoting resolution of inflammation and reducing extensive tissue damage [46].
T122 2788-3119 Sentence denotes Lastly, promising in vitro and preclinical data suggest that vitamin C supplementation could play a role on more recently discovered functions of neutrophils, such as the formation of neutrophil extracellular traps (NETs), resulting by the release of toxic intracellular components following the necrotic death of neutrophils [56].
T123 3120-3198 Sentence denotes Ascorbic acid may attenuate tissue damage reducing the formation of NETs [48].
T124 3199-3311 Sentence denotes Furthermore, vitamin C is effective in supporting both the humoral response and the cell-mediated immunity [46].
T125 3312-3475 Sentence denotes Vitamin C accumulates in phagocytic cells, such as neutrophils, and can enhance chemotaxis, phagocytosis, generation of ROS, and ultimately microbial killing [57].
T126 3476-3651 Sentence denotes It is also needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage.
T127 3652-3832 Sentence denotes The role of vitamin C in lymphocytes is less clear, but it has been shown to enhance differentiation and proliferation of B- and T-cells, likely due to its gene-regulating effects.
T128 3833-3949 Sentence denotes The effect of vitamin C on cytokine generation appears to depend on the cell type and/or the inflammatory stimulant.
T129 3950-4086 Sentence denotes Recent research has indicated that vitamin C treatment attenuates synthesis of the pro-inflammatory cytokines TNF, IL-6, and IL-1β [57].
T130 4087-4356 Sentence denotes In vitro studies suggest that ascorbic acid operates as potent immunostimulator of antibody production (IgM and IgG) in humans and that the intracellular ascorbic acid content is a key parameter for establishing the immune response of peripheral blood lymphocytes [58].
T131 4357-4449 Sentence denotes Other in vitro studies have shown the role of vitamin C in promoting T-cell maturation [59].
T132 4450-4649 Sentence denotes Recent research indicates the possible role of vitamin C in regulating T-cell maturation via epigenetic mechanisms involving in the ten-eleven translocations (TETs) and histone demethylation [60,61].
T133 4651-4655 Sentence denotes 4.2.
T134 4656-4672 Sentence denotes Vitamin C Status
T135 4673-4724 Sentence denotes Normal plasma vitamin C concentration is 50 µmol/L.
T136 4725-4852 Sentence denotes Plasma ascorbate concentrations above 10 µmol/L but below 50 µmol/L represent a status with an increased risk of insufficiency.
T137 4853-5023 Sentence denotes Scurvy appears when the plasma concentration falls below 10 µmol/L, which corresponds to an intake of less than 10 mg vitamin C/day and a body pool less than 300 mg [60].
T138 5024-5208 Sentence denotes It is acknowledged that vitamin C concentration declines during stress and infection, particularly in leukocytes, as it is used to protect host cells against the oxidative stress [46].
T139 5209-5332 Sentence denotes For the same reason, children exposed to smoking or environmental tobacco smoke require increased intake of vitamin C [44].
T140 5334-5338 Sentence denotes 4.3.
T141 5339-5386 Sentence denotes Recommended Daily Allowance and Supplementation
T142 5387-5597 Sentence denotes In adults, the average requirement of vitamin C is considered to be the amount that compensates for the metabolic losses of vitamin C and ensures a fasting ascorbate plasma level of 50 µmol/L [62,63] (Table 1).
T143 5598-5682 Sentence denotes In infants and children, no data for deriving the average requirement are available.
T144 5683-5827 Sentence denotes The European Food Safety Authority (EFSA) extrapolated the vitamin C requirement in this age group from the vitamin C requirement in adult [62].
T145 5829-5833 Sentence denotes 4.4.
T146 5834-5883 Sentence denotes Vitamin C Supplementation against Viral Infection
T147 5884-6055 Sentence denotes Vitamin C deficiency status is correlated with an increased susceptibility to severe respiratory infections such as pneumonia [46,47,64,65,66,67,68,69,70,71,72] (Table 3).
T148 6056-6205 Sentence denotes In a recent meta-analysis, Hemilä and Louhiala analyzed the effect of vitamin C in preventing and treating pneumonia regardless of the etiology [65].
T149 6206-6449 Sentence denotes They reported three studies that show a >80% lower incidence of pneumonia in the vitamin C groups, supporting the potential role of vitamin C in reducing the risk of pneumonia, particularly in individuals with low plasma vitamin C levels [66].
T150 6450-6659 Sentence denotes Furthermore, regarding the effect of vitamin C in treating pneumonia, in older patients, lower mortality and reduced severity of disease was found in the vitamin C group, particularly in the most ill patients.
T151 6660-6932 Sentence denotes However, the authors concluded that the current evidence is too weak to advocate widespread prophylactic use of vitamin C to prevent pneumonia in the general population, and further studies are needed to clarify the population that could have a benefit from vitamin C use.
T152 6933-7061 Sentence denotes The effect of vitamin C on upper respiratory tract infections, such as the common cold, has also been studied in several trials.
T153 7062-7208 Sentence denotes Vitamin C supplementation significantly decreases the incidence and the severity of the common cold in people under heavy physical stress [67,68].
T154 7209-7495 Sentence denotes In a randomised controlled pilot study, Garaiova et al. have shown a significant reduction in the incidence and duration of upper respiratory tract infection, but no significant differences were observed in the incidence rate ratio or duration of lower respiratory tract infection [69].
T155 7496-7777 Sentence denotes A recent meta-analysis comparing vitamin C with placebo demonstrated that administration of extra doses of vitamin C at the onset of a common cold could help reduce the duration by about half a day, shorten the time confined indoors, and relieve the symptoms of a common cold [70].
T156 7778-7921 Sentence denotes With the COVID-19 outbreak, vitamin C could play a role in preventing and treating the severe respiratory viral infection caused by SARS-CoV-2.
T157 7922-8120 Sentence denotes The potential beneficial effect of vitamin C supplementation could be expected also from the depleted vitamin C levels that are present during a severe infection and in critically ill patients [71].
T158 8121-8457 Sentence denotes A recent randomised clinical trial (CITRIS-ALI) demonstrated that 96 hours’ infusion of vitamin C compared with placebo in patients with sepsis and ARDS did not improve the primary outcome of organ dysfunction scores, but significantly reduced mortality and significantly increased ICU-free days to 28 and hospital-free days to 60 [72].
T159 8458-8651 Sentence denotes Recently, Diao et al. retrospectively reviewed the numbers of total T cells, CD4+, CD8+ T cell subsets in a total of 499 COVID-19 patients and found a significantly reduction of T cells counts.
T160 8652-8769 Sentence denotes Furthermore, they demonstrated a state of T cell dysfunction (T cell exhaustion) following SARS-CoV-2 infection [73].
T161 8770-9032 Sentence denotes Thus, the possibility that vitamin C affects viral respiratory tract infections, also supporting the viral clearance mediated by T cells, could encourage further studies aimed to investigate the role of vitamin C for prevention and treatment of COVID-19 disease.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
335 3-12 Chemical denotes Vitamin C MESH:D001205
345 132-138 Species denotes humans Tax:9606
346 198-206 Species denotes potatoes Tax:4113
347 467-474 Species denotes infants Tax:9606
348 44-53 Chemical denotes Vitamin C MESH:D001205
349 55-68 Chemical denotes ascorbic acid MESH:D001205
350 75-80 Chemical denotes water MESH:D014867
351 160-169 Chemical denotes vitamin C MESH:D001205
352 261-270 Chemical denotes vitamin C MESH:D001205
353 440-449 Chemical denotes vitamin C MESH:D001205
365 983-994 Gene denotes transferrin Gene:7018
366 476-489 Chemical denotes Ascorbic acid MESH:D001205
367 626-637 Chemical denotes cholesterol MESH:D002784
368 650-660 Chemical denotes fatty acid MESH:D005227
369 685-694 Chemical denotes carnitine MESH:D002331
370 713-717 Chemical denotes iron MESH:D007501
371 817-826 Chemical denotes vitamin C MESH:D001205
372 940-944 Chemical denotes iron MESH:D007501
373 973-977 Chemical denotes iron MESH:D007501
374 1029-1049 Chemical denotes tetrahydrofolic acid MESH:C030371
375 722-734 Disease denotes copper atoms MESH:C535468
400 2247-2255 Species denotes children Tax:9606
401 2418-2426 Species denotes patients Tax:9606
402 1056-1065 Chemical denotes Vitamin C MESH:D001205
403 1219-1228 Chemical denotes vitamin C MESH:D001205
404 1314-1320 Chemical denotes sodium MESH:D012964
405 1432-1441 Chemical denotes Vitamin C MESH:D001205
406 1454-1459 Chemical denotes water MESH:D014867
407 1606-1629 Chemical denotes reactive oxygen species MESH:D017382
408 1631-1634 Chemical denotes ROS MESH:D017382
409 1753-1761 Chemical denotes ascorbic
410 1778-1781 Chemical denotes ROS MESH:D017382
411 1928-1937 Chemical denotes Vitamin C MESH:D001205
412 2548-2557 Chemical denotes vitamin C MESH:D001205
413 2632-2645 Chemical denotes Ascorbic acid MESH:D001205
414 2849-2858 Chemical denotes vitamin C MESH:D001205
415 3120-3133 Chemical denotes Ascorbic acid MESH:D001205
416 2139-2155 Disease denotes septic syndromes MESH:D012772
417 2319-2328 Disease denotes infection MESH:D007239
418 2337-2367 Disease denotes status of vitamin C deficiency MESH:D001206
419 2442-2452 Disease denotes infections MESH:D007239
420 2495-2519 Disease denotes Chediak–Higashi syndrome MESH:D002609
421 2521-2524 Disease denotes CHS MESH:D002609
422 2732-2744 Disease denotes inflammation MESH:D007249
423 3084-3098 Disease denotes necrotic death MESH:D003643
441 4060-4063 Gene denotes TNF Gene:7124
442 4065-4069 Gene denotes IL-6 Gene:3569
443 4075-4080 Gene denotes IL-1β Gene:3552
444 4207-4213 Species denotes humans Tax:9606
445 3212-3221 Chemical denotes vitamin C MESH:D001205
446 3312-3321 Chemical denotes Vitamin C MESH:D001205
447 3432-3435 Chemical denotes ROS MESH:D017382
448 3664-3673 Chemical denotes vitamin C MESH:D001205
449 3847-3856 Chemical denotes vitamin C MESH:D001205
450 3985-3994 Chemical denotes vitamin C MESH:D001205
451 4117-4130 Chemical denotes ascorbic acid MESH:D001205
452 4241-4254 Chemical denotes ascorbic acid MESH:D001205
453 4403-4412 Chemical denotes vitamin C MESH:D001205
454 4497-4506 Chemical denotes vitamin C MESH:D001205
455 3561-3570 Disease denotes infection MESH:D007239
456 3606-3614 Disease denotes necrosis MESH:D009336
457 3615-3622 Disease denotes NETosis
459 4656-4665 Chemical denotes Vitamin C MESH:D001205
473 5230-5238 Species denotes children Tax:9606
474 5275-5282 Species denotes tobacco Tax:4097
475 4918-4919 Gene denotes L Gene:21832
476 4791-4792 Gene denotes L Gene:21832
477 4771-4772 Gene denotes L Gene:21832
478 4722-4723 Gene denotes L Gene:21832
479 4687-4696 Chemical denotes vitamin C MESH:D001205
480 4732-4741 Chemical denotes ascorbate MESH:D001205
481 4971-4980 Chemical denotes vitamin C MESH:D001205
482 5048-5057 Chemical denotes vitamin C MESH:D001205
483 5317-5326 Chemical denotes vitamin C MESH:D001205
484 4838-4851 Disease denotes insufficiency MESH:D000309
485 5099-5108 Disease denotes infection MESH:D007239
491 5425-5434 Chemical denotes vitamin C MESH:D001205
492 5511-5520 Chemical denotes vitamin C MESH:D001205
493 5543-5552 Chemical denotes ascorbate MESH:D001205
498 5601-5608 Species denotes infants Tax:9606
499 5613-5621 Species denotes children Tax:9606
500 5742-5751 Chemical denotes vitamin C MESH:D001205
501 5791-5800 Chemical denotes vitamin C MESH:D001205
504 5834-5843 Chemical denotes Vitamin C MESH:D001205
505 5868-5883 Disease denotes Viral Infection MESH:D001102
509 5892-5904 Disease denotes C deficiency MESH:C537418
510 5969-5991 Disease denotes respiratory infections MESH:D012141
511 6000-6009 Disease denotes pneumonia MESH:D011014
536 6529-6537 Species denotes patients Tax:9606
537 6650-6658 Species denotes patients Tax:9606
538 7165-7171 Species denotes people Tax:9606
539 6126-6135 Chemical denotes vitamin C MESH:D001205
540 6287-6296 Chemical denotes vitamin C MESH:D001205
541 6338-6347 Chemical denotes vitamin C MESH:D001205
542 6427-6436 Chemical denotes vitamin C MESH:D001205
543 6487-6496 Chemical denotes vitamin C MESH:D001205
544 6604-6613 Chemical denotes vitamin C MESH:D001205
545 6772-6781 Chemical denotes vitamin C MESH:D001205
546 6918-6927 Chemical denotes vitamin C MESH:D001205
547 6947-6956 Chemical denotes vitamin C MESH:D001205
548 7062-7071 Chemical denotes Vitamin C MESH:D001205
549 7529-7538 Chemical denotes vitamin C MESH:D001205
550 7603-7612 Chemical denotes vitamin C MESH:D001205
551 6163-6172 Disease denotes pneumonia MESH:D011014
552 6270-6279 Disease denotes pneumonia MESH:D011014
553 6372-6381 Disease denotes pneumonia MESH:D011014
554 6509-6518 Disease denotes pneumonia MESH:D011014
555 6545-6554 Disease denotes mortality MESH:D003643
556 6793-6802 Disease denotes pneumonia MESH:D011014
557 6960-6994 Disease denotes upper respiratory tract infections MESH:D012141
558 7333-7366 Disease denotes upper respiratory tract infection MESH:D012141
559 7462-7489 Disease denotes respiratory tract infection MESH:D012141
575 7910-7920 Species denotes SARS-CoV-2 Tax:2697049
576 8106-8114 Species denotes patients Tax:9606
577 8244-8252 Species denotes patients Tax:9606
578 7872-7883 Species denotes respiratory Tax:12814
579 7806-7815 Chemical denotes vitamin C MESH:D001205
580 7957-7966 Chemical denotes vitamin C MESH:D001205
581 8024-8033 Chemical denotes vitamin C MESH:D001205
582 8209-8218 Chemical denotes vitamin C MESH:D001205
583 7787-7795 Disease denotes COVID-19 MESH:C000657245
584 7884-7899 Disease denotes viral infection MESH:D001102
585 8074-8083 Disease denotes infection MESH:D007239
586 8091-8105 Disease denotes critically ill MESH:D016638
587 8258-8264 Disease denotes sepsis MESH:D018805
588 8269-8273 Disease denotes ARDS MESH:D012128
589 8365-8374 Disease denotes mortality MESH:D003643
600 8535-8538 Gene denotes CD4 Gene:920
601 8541-8544 Gene denotes CD8 Gene:925
602 8588-8596 Species denotes patients Tax:9606
603 8797-8806 Chemical denotes vitamin C MESH:D001205
604 8973-8982 Chemical denotes vitamin C MESH:D001205
605 8579-8587 Disease denotes COVID-19 MESH:C000657245
606 8694-8712 Disease denotes T cell dysfunction MESH:C536780
607 8748-8763 Disease denotes CoV-2 infection MESH:C000657245
608 8821-8849 Disease denotes respiratory tract infections MESH:D012141
609 9015-9023 Disease denotes COVID-19 MESH:C000657245