PMC:7573178 / 2955-4084 JSONTXT

{"project":"MyTest","denotations":[{"id":"33088257-30345373-29795625","span":{"begin":100,"end":102},"obj":"30345373"},{"id":"33088257-24723629-29795626","span":{"begin":247,"end":248},"obj":"24723629"},{"id":"33088257-31081985-29795627","span":{"begin":602,"end":604},"obj":"31081985"},{"id":"33088257-21684723-29795628","span":{"begin":886,"end":887},"obj":"21684723"},{"id":"33088257-24107543-29795629","span":{"begin":908,"end":910},"obj":"24107543"},{"id":"33088257-24035489-29795630","span":{"begin":935,"end":937},"obj":"24035489"},{"id":"33088257-30223673-29795631","span":{"begin":960,"end":962},"obj":"30223673"},{"id":"33088257-29423959-29795632","span":{"begin":1125,"end":1126},"obj":"29423959"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Genetic mechanisms are one of the biological factors affecting the resilience (Navrady et al., 2018[32]). Some investigations have determined that this process has a heritability of approximately 31 %, with sex differences (Amstadter et al., 2014[3]). These results suggest that specific genes could be playing an important role in this psychological process. A genome-wide association study (GWAS) has identified that in European soldiers four Single Nucleotide Polymorphisms (SNPs) in DCLK2 gene are related to self-assessed resilience, in addition to variants in the KLHL36 gene (Stein et al., 2019[43]). On the other hand, studies focused in evaluating candidate genes have found that some polymorphisms in genes involved in synaptic plasticity, such as SLC6A4, BDNF, DRD4 and COMT, have been associated with resilience levels in people with or without diseases (Carli et al., 2011[7]; Kang et al., 2013[25]; La Greca et al., 2013[28]; Niitsu et al., 2019[33]). In addition to SNPs, changes in expression of dopaminergic genes have also been correlated with differences in resilient responses (Azadmarzabadi et al., 2018[4])."}

{"project":"2_test","denotations":[{"id":"33088257-30345373-29795625","span":{"begin":100,"end":102},"obj":"30345373"},{"id":"33088257-24723629-29795626","span":{"begin":247,"end":248},"obj":"24723629"},{"id":"33088257-31081985-29795627","span":{"begin":602,"end":604},"obj":"31081985"},{"id":"33088257-21684723-29795628","span":{"begin":886,"end":887},"obj":"21684723"},{"id":"33088257-24107543-29795629","span":{"begin":908,"end":910},"obj":"24107543"},{"id":"33088257-24035489-29795630","span":{"begin":935,"end":937},"obj":"24035489"},{"id":"33088257-30223673-29795631","span":{"begin":960,"end":962},"obj":"30223673"},{"id":"33088257-29423959-29795632","span":{"begin":1125,"end":1126},"obj":"29423959"}],"text":"Genetic mechanisms are one of the biological factors affecting the resilience (Navrady et al., 2018[32]). Some investigations have determined that this process has a heritability of approximately 31 %, with sex differences (Amstadter et al., 2014[3]). These results suggest that specific genes could be playing an important role in this psychological process. A genome-wide association study (GWAS) has identified that in European soldiers four Single Nucleotide Polymorphisms (SNPs) in DCLK2 gene are related to self-assessed resilience, in addition to variants in the KLHL36 gene (Stein et al., 2019[43]). On the other hand, studies focused in evaluating candidate genes have found that some polymorphisms in genes involved in synaptic plasticity, such as SLC6A4, BDNF, DRD4 and COMT, have been associated with resilience levels in people with or without diseases (Carli et al., 2011[7]; Kang et al., 2013[25]; La Greca et al., 2013[28]; Niitsu et al., 2019[33]). In addition to SNPs, changes in expression of dopaminergic genes have also been correlated with differences in resilient responses (Azadmarzabadi et al., 2018[4])."}