PMC:7573174 / 3067-4341
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7573174","sourcedb":"PMC","sourceid":"7573174","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7573174","text":"Previous studies have focused on the final structures by self-assembly or the reaction products via breaking or forming covalent bonds by enzymatic covalent synthesis (Lewis et al., 2011[48]; Vaissier Welborn and Head-Gordon, 2018[77]). Recent development in molecular biology and cell biology reveal the significance of enzymatic supramolecular (i.e., noncovalent) assemblies for cell functions. Such insights have led to the exploration of enzymatic noncovalent synthesis, a process that incorporates both enzymatic covalent synthesis and noncovalent assemblies to form higher-order structures (Shy et al., 2019[73]). Enzymatic noncovalent synthesis usually starts from a less ordered system where the precursors undergo enzymatic reactions (e.g., enzymatic cleavage) to initiate self-assembly to result in morphological transformation (Yang and Xu, 2006[107]; Yang et al., 2004[104]). One usual result of enzymatic noncovalent synthesis of small molecules is the formation of molecular nanofibers. The entangling nanofibers form networks that trap water inside, altering rheological properties of the solution to generate hydrogels. Therefore, hydrogelation or phase transition is a good indication of self-assembly in water resulted from enzymatic noncovalent synthesis.","tracks":[{"project":"2_test","denotations":[{"id":"33088250-21079862-29803033","span":{"begin":187,"end":189},"obj":"21079862"},{"id":"33088250-30277066-29803034","span":{"begin":231,"end":233},"obj":"30277066"},{"id":"33088250-32104791-29803035","span":{"begin":614,"end":616},"obj":"32104791"}],"attributes":[{"subj":"33088250-21079862-29803033","pred":"source","obj":"2_test"},{"subj":"33088250-30277066-29803034","pred":"source","obj":"2_test"},{"subj":"33088250-32104791-29803035","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"33088250-21079862-29803033","span":{"begin":187,"end":189},"obj":"21079862"},{"id":"33088250-30277066-29803034","span":{"begin":231,"end":233},"obj":"30277066"},{"id":"33088250-32104791-29803035","span":{"begin":614,"end":616},"obj":"32104791"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"33088250-21079862-29803033","pred":"source","obj":"MyTest"},{"subj":"33088250-30277066-29803034","pred":"source","obj":"MyTest"},{"subj":"33088250-32104791-29803035","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93db","default":true},{"id":"MyTest","color":"#93ece3"}]}]}}