PMC:7572937 / 25109-25878 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7572937","sourcedb":"PMC","sourceid":"7572937","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7572937","text":"Respiratory failure due to lung damage is accompanied by airway contraction, which can be induced by various damage-associated molecular patterns, among which mitochondrial N-formyl peptides act via FPR272. AERD is another disease in which the overactivated LXA4/FPR2 pathway exacerbates the pathogenesis. Because AERD is associated with arachidonic acid metabolism, the role of FPR2 in recognizing LXA4 is important in regulating AERD progression. Single-nucleotide polymorphism analyses have been conducted in AERD patients, showing that these patients have a high frequency of homozygote of the minor allele, FPR2-4509T\u003eG. This minor allele is correlated with higher FPR2 levels in CD14+ monocytes, and carriers show defective lung function upon aspirin challenge63.","tracks":[{"project":"MyTest","denotations":[{"id":"33082511-26923940-29997609","span":{"begin":202,"end":205},"obj":"26923940"},{"id":"33082511-22377711-29997610","span":{"begin":766,"end":768},"obj":"22377711"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"33082511-26923940-29997609","pred":"source","obj":"MyTest"},{"subj":"33082511-22377711-29997610","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"33082511-26923940-29997609","span":{"begin":202,"end":205},"obj":"26923940"},{"id":"33082511-22377711-29997610","span":{"begin":766,"end":768},"obj":"22377711"}],"attributes":[{"subj":"33082511-26923940-29997609","pred":"source","obj":"2_test"},{"subj":"33082511-22377711-29997610","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#ecd493","default":true},{"id":"2_test","color":"#ba93ec"}]}]}}