PMC:7572507 / 159-1979 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7572507","sourcedb":"PMC","sourceid":"7572507","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7572507","text":"Background\nPatients with cancer are at increased risk of complicated severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, but it is still unclear if the risk of mortality is influenced by cancer type or ongoing anti-cancer treatments. An interesting debate concerning the potential relationship between androgen deprivation therapy (ADT) and SARS-CoV-2 infection has recently been opened in the case of prostate cancer (PC), and the aim of this multi-centre cohort study was to investigate the incidence and outcomes of SARS-CoV-2 infection in patients with metastatic castration-resistant prostrate cancer (mCRPC).\n\nPatients and methods\nWe retrospectively reviewed the clinical records of patients with mCRPC who developed SARS-CoV-2 infection, and recorded their baseline clinical characteristics, their history of PC and SARS-CoV-2 infection, and their oncological status and treatment at the time of infection. The primary study end point was the death rate and the possible impact of the patients' PC-related history and treatments on mortality.\n\nResults\nThirty-four of the 1433 patients with mCRPC attending the participating centres (2.3%) developed SARS-CoV-2 infection, 22 (64.7%) of whom were hospitalised. Most of the patients were symptomatic, the most frequent symptoms being fever (70.6%), dyspnoea (61.8%), cough (52.9%) and fatigue (38.2%). After a median follow-up of 21 days (interquartile range: 13–41), 13 patients had died (38.2%), 17 recovered (50.0%) and four (11.7%) were still infected. The number of treatments previously administered for mCRPC had a significant impact on mortality (p = 0.004).\n\nConclusions\nOur findings contribute additional data to the current debate concerning the postulated protective role of ADT, which seems to be less in patients with metastatic PC.","divisions":[{"label":"sec","span":{"begin":0,"end":634}},{"label":"title","span":{"begin":0,"end":10}},{"label":"p","span":{"begin":11,"end":634}},{"label":"sec","span":{"begin":636,"end":1069}},{"label":"title","span":{"begin":636,"end":656}},{"label":"p","span":{"begin":657,"end":1069}},{"label":"sec","span":{"begin":1071,"end":1640}},{"label":"title","span":{"begin":1071,"end":1078}},{"label":"p","span":{"begin":1079,"end":1640}},{"label":"title","span":{"begin":1642,"end":1653}}],"tracks":[]}