PMC:7572126 / 28642-30541
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7572126","sourcedb":"PMC","sourceid":"7572126","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7572126","text":"The relationships between risk exposures, microbiome traits, and biological risk, that we report are highly biologically credible. For example, serum IL-15 concentration has been shown to be higher in patients with cardiovascular disease, compared to patients without the disease (Krolopp et al., 2016). IL-15 is a potent regulator of glucose uptake (Kameyama and Itoh, 2014), although whether its production is increased as a result of high sugar consumption is not currently well-understood. Lachnospiraceae bacterium 8_1_57FAA (NCBI:txid665951) was found to mediate the overall association between increased sugar-sweetened beverage consumption and increased serum concentration of IL-15, even after adjusting for multiple factors that may influence this mediatory relationship. We also observed a relationship between sugar-sweetened beverage consumption and diastolic blood pressure. Members of Lachnospiraceae, a family of bacteria in the order of Clostridiales and part of the normal human gut microbiota, have been implicated in the risk of metabolic (Liu et al., 2018; Lippert et al., 2017; Schirmer et al., 2016) and cardiovascular (Lippert et al., 2017) disease. In particular, associated Lachnospiraceae bacterium 8_1_57FAA has been associated with host cytokine levels (Wang et al., 2019) and BMI (Turnbaugh et al., 2007), although the underlying mechanisms that underpin these relationships remain poorly understood. Lachnospiraceae bacterium 8_1_57FAA is an uncultured taxon, identified through metagenomic analysis of human fecal material (Jie et al., 2017). It represents a little-known bacterium on the phylogenetic periphery of the Lachnospiraceae family. As applies to many of the taxa identified through metagenomics as influencing risk exposures-metabolic disease relationships, detailed characterization of this bacterium is required to better understand mediatory mechanisms.","tracks":[{"project":"MyTest","denotations":[{"id":"33074097-28066259-26739275","span":{"begin":297,"end":301},"obj":"28066259"},{"id":"33074097-25283478-26739276","span":{"begin":370,"end":374},"obj":"25283478"},{"id":"33074097-30021609-26739277","span":{"begin":1072,"end":1076},"obj":"30021609"},{"id":"33074097-28701081-26739278","span":{"begin":1094,"end":1098},"obj":"28701081"},{"id":"33074097-27814509-26739279","span":{"begin":1117,"end":1121},"obj":"27814509"},{"id":"33074097-28701081-26739280","span":{"begin":1159,"end":1163},"obj":"28701081"},{"id":"33074097-17943116-26739281","span":{"begin":1329,"end":1333},"obj":"17943116"},{"id":"33074097-29018189-26739282","span":{"begin":1568,"end":1572},"obj":"29018189"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"33074097-28066259-26739275","pred":"source","obj":"MyTest"},{"subj":"33074097-25283478-26739276","pred":"source","obj":"MyTest"},{"subj":"33074097-30021609-26739277","pred":"source","obj":"MyTest"},{"subj":"33074097-28701081-26739278","pred":"source","obj":"MyTest"},{"subj":"33074097-27814509-26739279","pred":"source","obj":"MyTest"},{"subj":"33074097-28701081-26739280","pred":"source","obj":"MyTest"},{"subj":"33074097-17943116-26739281","pred":"source","obj":"MyTest"},{"subj":"33074097-29018189-26739282","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"33074097-28066259-26739275","span":{"begin":297,"end":301},"obj":"28066259"},{"id":"33074097-25283478-26739276","span":{"begin":370,"end":374},"obj":"25283478"},{"id":"33074097-30021609-26739277","span":{"begin":1072,"end":1076},"obj":"30021609"},{"id":"33074097-28701081-26739278","span":{"begin":1094,"end":1098},"obj":"28701081"},{"id":"33074097-27814509-26739279","span":{"begin":1117,"end":1121},"obj":"27814509"},{"id":"33074097-28701081-26739280","span":{"begin":1159,"end":1163},"obj":"28701081"},{"id":"33074097-17943116-26739281","span":{"begin":1329,"end":1333},"obj":"17943116"},{"id":"33074097-29018189-26739282","span":{"begin":1568,"end":1572},"obj":"29018189"}],"attributes":[{"subj":"33074097-28066259-26739275","pred":"source","obj":"2_test"},{"subj":"33074097-25283478-26739276","pred":"source","obj":"2_test"},{"subj":"33074097-30021609-26739277","pred":"source","obj":"2_test"},{"subj":"33074097-28701081-26739278","pred":"source","obj":"2_test"},{"subj":"33074097-27814509-26739279","pred":"source","obj":"2_test"},{"subj":"33074097-28701081-26739280","pred":"source","obj":"2_test"},{"subj":"33074097-17943116-26739281","pred":"source","obj":"2_test"},{"subj":"33074097-29018189-26739282","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#93dbec","default":true},{"id":"2_test","color":"#ece393"}]}]}}