PMC:7572126 / 2388-3773
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7572126","sourcedb":"PMC","sourceid":"7572126","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7572126","text":"The role of host-microbiome interactions in shaping the impact of changing risk exposures is increasingly recognized (Clemente et al., 2018; Wen and Duffy, 2017; Levy et al., 2017). Intestinal microbial populations exert a profound influence over host metabolism, energy homeostasis, and innate and adaptive immunity (Martin et al., 2019; Morgan et al., 2015; O'Keefe et al., 2015), and are highly responsive to dietary and lifestyle exposures (David et al., 2014; Engen et al., 2015; He et al., 2018). Our understanding of these interactions is based on the analysis of predominantly urban, high income, European and North American populations. However, associations between the intestinal microbiome and population geography (Brooks et al., 2018), ethnicity (Vangay et al., 2018), and cultural background (Queensland Health, 2017) are well characterized. Since the influence of the microbiome on host physiology is likely to be similarly context-dependent, existing models of microbiome-mediation may not be appropriate for remote Indigenous communities in resource-limited settings. Instead, the complexity of interactions between diet, environment, lifestyle, human genetics, intestinal microbiology, and other factors, necessitate accurate modeling of changing patterns of disease at a community-level, and such efforts should arguably focus on those communities at greatest risk.","tracks":[{"project":"MyTest","denotations":[{"id":"33074097-29311119-26739254","span":{"begin":135,"end":139},"obj":"29311119"},{"id":"33074097-28615382-26739255","span":{"begin":156,"end":160},"obj":"28615382"},{"id":"33074097-27883933-26739256","span":{"begin":175,"end":179},"obj":"27883933"},{"id":"33074097-31057420-26739257","span":{"begin":333,"end":337},"obj":"31057420"},{"id":"33074097-25887922-26739258","span":{"begin":354,"end":358},"obj":"25887922"},{"id":"33074097-25919227-26739259","span":{"begin":376,"end":380},"obj":"25919227"},{"id":"33074097-24336217-26739260","span":{"begin":459,"end":463},"obj":"24336217"},{"id":"33074097-26695747-26739261","span":{"begin":479,"end":483},"obj":"26695747"},{"id":"33074097-30150716-26739262","span":{"begin":496,"end":500},"obj":"30150716"},{"id":"33074097-30513082-26739263","span":{"begin":743,"end":747},"obj":"30513082"},{"id":"33074097-30388453-26739264","span":{"begin":776,"end":780},"obj":"30388453"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"33074097-29311119-26739254","pred":"source","obj":"MyTest"},{"subj":"33074097-28615382-26739255","pred":"source","obj":"MyTest"},{"subj":"33074097-27883933-26739256","pred":"source","obj":"MyTest"},{"subj":"33074097-31057420-26739257","pred":"source","obj":"MyTest"},{"subj":"33074097-25887922-26739258","pred":"source","obj":"MyTest"},{"subj":"33074097-25919227-26739259","pred":"source","obj":"MyTest"},{"subj":"33074097-24336217-26739260","pred":"source","obj":"MyTest"},{"subj":"33074097-26695747-26739261","pred":"source","obj":"MyTest"},{"subj":"33074097-30150716-26739262","pred":"source","obj":"MyTest"},{"subj":"33074097-30513082-26739263","pred":"source","obj":"MyTest"},{"subj":"33074097-30388453-26739264","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"33074097-29311119-26739254","span":{"begin":135,"end":139},"obj":"29311119"},{"id":"33074097-28615382-26739255","span":{"begin":156,"end":160},"obj":"28615382"},{"id":"33074097-27883933-26739256","span":{"begin":175,"end":179},"obj":"27883933"},{"id":"33074097-31057420-26739257","span":{"begin":333,"end":337},"obj":"31057420"},{"id":"33074097-25887922-26739258","span":{"begin":354,"end":358},"obj":"25887922"},{"id":"33074097-25919227-26739259","span":{"begin":376,"end":380},"obj":"25919227"},{"id":"33074097-24336217-26739260","span":{"begin":459,"end":463},"obj":"24336217"},{"id":"33074097-26695747-26739261","span":{"begin":479,"end":483},"obj":"26695747"},{"id":"33074097-30150716-26739262","span":{"begin":496,"end":500},"obj":"30150716"},{"id":"33074097-30513082-26739263","span":{"begin":743,"end":747},"obj":"30513082"},{"id":"33074097-30388453-26739264","span":{"begin":776,"end":780},"obj":"30388453"}],"attributes":[{"subj":"33074097-29311119-26739254","pred":"source","obj":"2_test"},{"subj":"33074097-28615382-26739255","pred":"source","obj":"2_test"},{"subj":"33074097-27883933-26739256","pred":"source","obj":"2_test"},{"subj":"33074097-31057420-26739257","pred":"source","obj":"2_test"},{"subj":"33074097-25887922-26739258","pred":"source","obj":"2_test"},{"subj":"33074097-25919227-26739259","pred":"source","obj":"2_test"},{"subj":"33074097-24336217-26739260","pred":"source","obj":"2_test"},{"subj":"33074097-26695747-26739261","pred":"source","obj":"2_test"},{"subj":"33074097-30150716-26739262","pred":"source","obj":"2_test"},{"subj":"33074097-30513082-26739263","pred":"source","obj":"2_test"},{"subj":"33074097-30388453-26739264","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#93c5ec","default":true},{"id":"2_test","color":"#dfec93"}]}]}}