PMC:7572125 / 39739-40663 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7572125","sourcedb":"PMC","sourceid":"7572125","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7572125","text":"PTEN-3’UTR luciferase reporter activity was also tested when the 3’UTR of putative PTEN ceRNAs were ectopically overexpressed, reported in Figure 2 of this study and Figure 3D of Tay et al., 2011. The direction of all six comparisons were in the opposite direction of the original study with none of the effect size point estimates within the confidence intervals of the other study (Figure 5B). The meta-analyses were not statistically significant, with all effects having large confidence intervals around the meta-analysis effect size along with statistically significant Cochran’s Q tests (SERINC1 3’UTR and empty vector, p=0.0011; VAPA 3’UTR1 and empty vector, p=2.55×10−4; VAPA 3’UTR2 and empty vector, p=1.28×10−6; CNOT6L 3’UTR1 and empty vector, p=1.07×10−5; CNOT6L 3’UTR2 and empty vector, p=2.54×10−5; PTEN 3’UTR and empty vector, p=1.86×10−6) suggesting heterogeneity between the original and replication studies.","tracks":[{"project":"2_test","denotations":[{"id":"33073769-22000013-27525642","span":{"begin":191,"end":195},"obj":"22000013"}],"attributes":[{"subj":"33073769-22000013-27525642","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"33073769-22000013-27525642","span":{"begin":191,"end":195},"obj":"22000013"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"33073769-22000013-27525642","pred":"source","obj":"MyTest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ec9c","default":true},{"id":"MyTest","color":"#ec93a3"}]}]}}