PMC:7572125 / 3710-5689
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7572125","sourcedb":"PMC","sourceid":"7572125","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7572125","text":"The Registered Report for the paper by Tay et al., 2011 described the experiments to be replicated (Figures 3C-D, 3G-H, 5A-B, and Supplemental Figures S3A-B), and summarized the current evidence for these findings (Phelps et al., 2016). Since that publication additional studies have reported finding other ceRNAs of PTEN. TNRC6B was identified as a ceRNA of PTEN with depletion of TNRC6B reported to decrease PTEN mRNA and protein expression in the prostate cancer cell lines DU145, 22RV1, and BM1604 and increase cell proliferation in DU145 and PC3 cells (Zarringhalam et al., 2017). Zarringhalam et al., 2017 also used CNOT6L in their study and reported depletion of CNOT6L produced similar results as TNRC6B depletion. DNMT3B and TET3 were recently reported to be ceRNAs of PTEN with miR-4465 identified as a microRNA regulating these three transcripts via their 3’UTRs (Roquid et al., 2019). Multiple studies have reported a growing list of potential ceRNAs, which includes mRNAs, pseudogenes, lncRNAs, and circRNAs (Gebert and MacRae, 2019; Li et al., 2018; Wang et al., 2016; Yang et al., 2016). For example, the lncRNA BGL3 has been identified as a ceRNA for PTEN to regulate Bcr-Abl-mediated cellular transformation in chronic myeloid leukemia (Guo et al., 2015) and c-Myc has been reported as a potential ceRNA for PML/RARα in acute promyelocytic leukemia (Ding et al., 2016). Prediction of putative ceRNAs are being reported using a variety of computational methods and data sources that construct ceRNA interaction networks (Chen et al., 2018; Chiu et al., 2017; Feng et al., 2019; Liu et al., 2019; Park et al., 2018b; Song et al., 2016; Sun et al., 2016; Swain and Mallick, 2018; Wang et al., 2019; Yue et al., 2019). Additionally, recently it has been reported that 3’UTR shortening of transcripts of predicted ceRNAs could be a potential mechanism of repressing tumor-suppressor genes, including PTEN, in trans by disrupting ceRNA cross-talk (Park et al., 2018a).","tracks":[{"project":"2_test","denotations":[{"id":"33073769-22000013-27525582","span":{"begin":51,"end":55},"obj":"22000013"},{"id":"33073769-26943900-27525583","span":{"begin":230,"end":234},"obj":"26943900"},{"id":"33073769-28798471-27525584","span":{"begin":579,"end":583},"obj":"28798471"},{"id":"33073769-28798471-27525585","span":{"begin":607,"end":611},"obj":"28798471"},{"id":"33073769-31894272-27525586","span":{"begin":890,"end":894},"obj":"31894272"},{"id":"33073769-30108335-27525587","span":{"begin":1041,"end":1045},"obj":"30108335"},{"id":"33073769-30217221-27525588","span":{"begin":1058,"end":1062},"obj":"30217221"},{"id":"33073769-26922301-27525589","span":{"begin":1077,"end":1081},"obj":"26922301"},{"id":"33073769-26872371-27525590","span":{"begin":1096,"end":1100},"obj":"26872371"},{"id":"33073769-24837367-27525591","span":{"begin":1266,"end":1270},"obj":"24837367"},{"id":"33073769-27486764-27525592","span":{"begin":1380,"end":1384},"obj":"27486764"},{"id":"33073769-29845268-27525593","span":{"begin":1550,"end":1554},"obj":"29845268"},{"id":"33073769-28558729-27525594","span":{"begin":1569,"end":1573},"obj":"28558729"},{"id":"33073769-30421585-27525595","span":{"begin":1588,"end":1592},"obj":"30421585"},{"id":"33073769-31106044-27525596","span":{"begin":1606,"end":1610},"obj":"31106044"},{"id":"33073769-26872060-27525598","span":{"begin":1645,"end":1649},"obj":"26872060"},{"id":"33073769-28536624-27525599","span":{"begin":1663,"end":1667},"obj":"28536624"},{"id":"33073769-29603582-27525600","span":{"begin":1688,"end":1692},"obj":"29603582"},{"id":"33073769-31186776-27525601","span":{"begin":1707,"end":1711},"obj":"31186776"},{"id":"33073769-30842787-27525602","span":{"begin":1725,"end":1729},"obj":"30842787"}],"attributes":[{"subj":"33073769-22000013-27525582","pred":"source","obj":"2_test"},{"subj":"33073769-26943900-27525583","pred":"source","obj":"2_test"},{"subj":"33073769-28798471-27525584","pred":"source","obj":"2_test"},{"subj":"33073769-28798471-27525585","pred":"source","obj":"2_test"},{"subj":"33073769-31894272-27525586","pred":"source","obj":"2_test"},{"subj":"33073769-30108335-27525587","pred":"source","obj":"2_test"},{"subj":"33073769-30217221-27525588","pred":"source","obj":"2_test"},{"subj":"33073769-26922301-27525589","pred":"source","obj":"2_test"},{"subj":"33073769-26872371-27525590","pred":"source","obj":"2_test"},{"subj":"33073769-24837367-27525591","pred":"source","obj":"2_test"},{"subj":"33073769-27486764-27525592","pred":"source","obj":"2_test"},{"subj":"33073769-29845268-27525593","pred":"source","obj":"2_test"},{"subj":"33073769-28558729-27525594","pred":"source","obj":"2_test"},{"subj":"33073769-30421585-27525595","pred":"source","obj":"2_test"},{"subj":"33073769-31106044-27525596","pred":"source","obj":"2_test"},{"subj":"33073769-26872060-27525598","pred":"source","obj":"2_test"},{"subj":"33073769-28536624-27525599","pred":"source","obj":"2_test"},{"subj":"33073769-29603582-27525600","pred":"source","obj":"2_test"},{"subj":"33073769-31186776-27525601","pred":"source","obj":"2_test"},{"subj":"33073769-30842787-27525602","pred":"source","obj":"2_test"}]},{"project":"MyTest","denotations":[{"id":"33073769-22000013-27525582","span":{"begin":51,"end":56},"obj":"22000013"},{"id":"33073769-26943900-27525583","span":{"begin":230,"end":234},"obj":"26943900"},{"id":"33073769-28798471-27525584","span":{"begin":579,"end":583},"obj":"28798471"},{"id":"33073769-28798471-27525585","span":{"begin":607,"end":612},"obj":"28798471"},{"id":"33073769-31894272-27525586","span":{"begin":890,"end":894},"obj":"31894272"},{"id":"33073769-30108335-27525587","span":{"begin":1041,"end":1045},"obj":"30108335"},{"id":"33073769-30217221-27525588","span":{"begin":1058,"end":1062},"obj":"30217221"},{"id":"33073769-26922301-27525589","span":{"begin":1077,"end":1081},"obj":"26922301"},{"id":"33073769-26872371-27525590","span":{"begin":1096,"end":1100},"obj":"26872371"},{"id":"33073769-24837367-27525591","span":{"begin":1266,"end":1270},"obj":"24837367"},{"id":"33073769-27486764-27525592","span":{"begin":1380,"end":1384},"obj":"27486764"},{"id":"33073769-29845268-27525593","span":{"begin":1550,"end":1554},"obj":"29845268"},{"id":"33073769-28558729-27525594","span":{"begin":1569,"end":1573},"obj":"28558729"},{"id":"33073769-30421585-27525595","span":{"begin":1588,"end":1592},"obj":"30421585"},{"id":"33073769-31106044-27525596","span":{"begin":1606,"end":1610},"obj":"31106044"},{"id":"33073769-26872060-27525598","span":{"begin":1645,"end":1649},"obj":"26872060"},{"id":"33073769-28536624-27525599","span":{"begin":1663,"end":1667},"obj":"28536624"},{"id":"33073769-29603582-27525600","span":{"begin":1688,"end":1692},"obj":"29603582"},{"id":"33073769-31186776-27525601","span":{"begin":1707,"end":1711},"obj":"31186776"},{"id":"33073769-30842787-27525602","span":{"begin":1725,"end":1729},"obj":"30842787"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniP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