PMC:7571312 / 8984-9188 JSONTXT

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T42","span":{"begin":159,"end":163},"obj":"Disease"}],"attributes":[{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"To better mimic the tetrahedral intermediate generated in the amide bond cleavage, we designed ketone-based covalent reversible and irreversible inhibitors of SARS CoV-1 3CLpro, as illustrated by 3 and 4."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T113","span":{"begin":62,"end":67},"obj":"Chemical"},{"id":"T115","span":{"begin":95,"end":101},"obj":"Chemical"},{"id":"T116","span":{"begin":145,"end":155},"obj":"Chemical"}],"attributes":[{"id":"A113","pred":"chebi_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/CHEBI_29337"},{"id":"A114","pred":"chebi_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/CHEBI_32988"},{"id":"A115","pred":"chebi_id","subj":"T115","obj":"http://purl.obolibrary.org/obo/CHEBI_17087"},{"id":"A116","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"}],"text":"To better mimic the tetrahedral intermediate generated in the amide bond cleavage, we designed ketone-based covalent reversible and irreversible inhibitors of SARS CoV-1 3CLpro, as illustrated by 3 and 4."}

{"project":"LitCovid-sentences","denotations":[{"id":"T44","span":{"begin":0,"end":204},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To better mimic the tetrahedral intermediate generated in the amide bond cleavage, we designed ketone-based covalent reversible and irreversible inhibitors of SARS CoV-1 3CLpro, as illustrated by 3 and 4."}

{"project":"LitCovid-PubTator","denotations":[{"id":"239","span":{"begin":159,"end":167},"obj":"Species"},{"id":"248","span":{"begin":62,"end":67},"obj":"Chemical"},{"id":"249","span":{"begin":95,"end":101},"obj":"Chemical"}],"attributes":[{"id":"A239","pred":"tao:has_database_id","subj":"239","obj":"Tax:694009"},{"id":"A248","pred":"tao:has_database_id","subj":"248","obj":"MESH:D000577"},{"id":"A249","pred":"tao:has_database_id","subj":"249","obj":"MESH:D007659"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"To better mimic the tetrahedral intermediate generated in the amide bond cleavage, we designed ketone-based covalent reversible and irreversible inhibitors of SARS CoV-1 3CLpro, as illustrated by 3 and 4."}