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PMC:7571312 / 89334-90525 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T632 397-398 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T633 518-520 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T634 548-549 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T635 967-969 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T636 1002-1007 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1625 77-84 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T1626 87-90 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1627 121-127 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1629 128-134 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1630 135-140 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1631 141-149 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T1632 151-164 Chemical denotes 3-methylbutyl http://purl.obolibrary.org/obo/CHEBI_30359
T1633 168-175 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1635 176-185 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1636 176-178 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1637 179-185 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1638 188-199 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1640 240-246 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T1641 249-252 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1642 283-289 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1644 290-296 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1645 297-302 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1646 303-311 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T1647 312-318 Chemical denotes pentyl http://purl.obolibrary.org/obo/CHEBI_25902
T1648 322-329 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1650 330-339 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1651 330-332 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1652 333-339 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1653 342-353 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1655 480-488 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T1656 489-499 Chemical denotes chloroform http://purl.obolibrary.org/obo/CHEBI_35255
T1657 562-564 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1658 570-574 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T1659 591-593 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1660 615-617 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1661 639-641 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1662 653-655 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1663 667-669 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1664 691-693 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1665 715-717 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1666 739-741 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1667 763-765 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1668 806-808 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1669 835-837 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1670 877-879 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1671 891-893 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1672 905-907 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1673 967-969 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T1674 1042-1045 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377
T1675 1050-1063 Chemical denotes ethyl acetate http://purl.obolibrary.org/obo/CHEBI_27750
T1676 1050-1055 Chemical denotes ethyl http://purl.obolibrary.org/obo/CHEBI_37807|http://purl.obolibrary.org/obo/CHEBI_62801
T1678 1056-1063 Chemical denotes acetate http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T517 0-417 Sentence denotes Following the procedure described for the preparation of N-((1S)-1-{[((1S)-3-hydroxy-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-1H-indole-2-carboxamide but substituting of N-((1S)-1-{[((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}pentyl)-4-methoxy-1H-indole-2-carboxamide and making noncritical variations provided a crude yellow foam.
T518 418-561 Sentence denotes This material was purified by Biotage MPLC (25 M column, 5–6% methanol/chloroform) to afford 82 mg (35%) of the title compound as a white foam.
T519 562-1093 Sentence denotes 1H NMR (DMSO-d6) δ 11.57 (s, 1H), 8.42 (d, J = 8 Hz, 1H), 8.38 (d, J = 8 Hz, 1H), 7.62 (s, 1H), 7.35 (s, 1H), 7.09 (t, J = 8 Hz, 1H), 6.99 (d, J = 8 Hz, 1H), 6.49 (d, J = 8 Hz, 1H), 5.06 (t, J = 8 Hz, 1H), 4.44 (m, 2H), 4.25 (dd, J = 8, 20 Hz, 1H), 4.14 (dd, J = 8, 20 Hz, 1H), 3.87 (s, 3H), 3.08 (m, 2H), 2.28 (m, 1H), 2.10 (m, 1H), 1.91 (m, 1H), 1.74–1.54 (m, 4H), 1.32 (m, 4H), 0.87 (t, J = 8 Hz, 3H); MS (ESI+) for C24H32N4O6m/z 473.2 (M + H)+; anal. calcd for C24H32N4O6·0.6 H2O·0.2 ethyl acetate: C, 59.46; H, 7.01; N, 11.18.
T520 1094-1191 Sentence denotes Found: C, 53.37; H, 6.94; N, 11.23; HRMS (ESI+) calcd for C24H32N4O6+H1 473.2395, found 473.2382.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1747 480-488 Chemical denotes methanol MESH:D000432
1748 489-499 Chemical denotes chloroform MESH:D002725
1749 1027-1037 Chemical denotes C24H32N4O6
1750 1042-1045 Chemical denotes H2O
1751 1050-1063 Chemical denotes ethyl acetate MESH:C007650
1752 1065-1066 Chemical denotes C MESH:D002244
1753 1084-1085 Chemical denotes N MESH:D009584
1754 1101-1102 Chemical denotes C MESH:D002244
1755 1120-1121 Chemical denotes N MESH:D009584
1756 1152-1162 Chemical denotes C24H32N4O6
1757 1130-1134 Disease denotes HRMS