
PMC:7571312 / 89334-90525
Annnotations
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T632 | 397-398 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T633 | 518-520 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
T634 | 548-549 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T635 | 967-969 | http://purl.obolibrary.org/obo/CLO_0007874 | denotes | MS |
T636 | 1002-1007 | http://purl.obolibrary.org/obo/CLO_0007706 | denotes | M + H |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T1625 | 77-84 | Chemical | denotes | hydroxy | http://purl.obolibrary.org/obo/CHEBI_43176 |
T1626 | 87-90 | Chemical | denotes | oxo | http://purl.obolibrary.org/obo/CHEBI_46629 |
T1627 | 121-127 | Chemical | denotes | methyl | http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309 |
T1629 | 128-134 | Chemical | denotes | propyl | http://purl.obolibrary.org/obo/CHEBI_26308 |
T1630 | 135-140 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T1631 | 141-149 | Chemical | denotes | carbonyl | http://purl.obolibrary.org/obo/CHEBI_23019 |
T1632 | 151-164 | Chemical | denotes | 3-methylbutyl | http://purl.obolibrary.org/obo/CHEBI_30359 |
T1633 | 168-175 | Chemical | denotes | methoxy | http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520 |
T1635 | 176-185 | Chemical | denotes | 1H-indole | http://purl.obolibrary.org/obo/CHEBI_16881 |
T1636 | 176-178 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1637 | 179-185 | Chemical | denotes | indole | http://purl.obolibrary.org/obo/CHEBI_35581 |
T1638 | 188-199 | Chemical | denotes | carboxamide | http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622 |
T1640 | 240-246 | Chemical | denotes | chloro | http://purl.obolibrary.org/obo/CHEBI_47853 |
T1641 | 249-252 | Chemical | denotes | oxo | http://purl.obolibrary.org/obo/CHEBI_46629 |
T1642 | 283-289 | Chemical | denotes | methyl | http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309 |
T1644 | 290-296 | Chemical | denotes | propyl | http://purl.obolibrary.org/obo/CHEBI_26308 |
T1645 | 297-302 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T1646 | 303-311 | Chemical | denotes | carbonyl | http://purl.obolibrary.org/obo/CHEBI_23019 |
T1647 | 312-318 | Chemical | denotes | pentyl | http://purl.obolibrary.org/obo/CHEBI_25902 |
T1648 | 322-329 | Chemical | denotes | methoxy | http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520 |
T1650 | 330-339 | Chemical | denotes | 1H-indole | http://purl.obolibrary.org/obo/CHEBI_16881 |
T1651 | 330-332 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1652 | 333-339 | Chemical | denotes | indole | http://purl.obolibrary.org/obo/CHEBI_35581 |
T1653 | 342-353 | Chemical | denotes | carboxamide | http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622 |
T1655 | 480-488 | Chemical | denotes | methanol | http://purl.obolibrary.org/obo/CHEBI_17790 |
T1656 | 489-499 | Chemical | denotes | chloroform | http://purl.obolibrary.org/obo/CHEBI_35255 |
T1657 | 562-564 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1658 | 570-574 | Chemical | denotes | DMSO | http://purl.obolibrary.org/obo/CHEBI_28262 |
T1659 | 591-593 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1660 | 615-617 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1661 | 639-641 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1662 | 653-655 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1663 | 667-669 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1664 | 691-693 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1665 | 715-717 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1666 | 739-741 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1667 | 763-765 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1668 | 806-808 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1669 | 835-837 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1670 | 877-879 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1671 | 891-893 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1672 | 905-907 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1673 | 967-969 | Chemical | denotes | MS | http://purl.obolibrary.org/obo/CHEBI_73613 |
T1674 | 1042-1045 | Chemical | denotes | H2O | http://purl.obolibrary.org/obo/CHEBI_15377 |
T1675 | 1050-1063 | Chemical | denotes | ethyl acetate | http://purl.obolibrary.org/obo/CHEBI_27750 |
T1676 | 1050-1055 | Chemical | denotes | ethyl | http://purl.obolibrary.org/obo/CHEBI_37807|http://purl.obolibrary.org/obo/CHEBI_62801 |
T1678 | 1056-1063 | Chemical | denotes | acetate | http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T517 | 0-417 | Sentence | denotes | Following the procedure described for the preparation of N-((1S)-1-{[((1S)-3-hydroxy-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-1H-indole-2-carboxamide but substituting of N-((1S)-1-{[((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}pentyl)-4-methoxy-1H-indole-2-carboxamide and making noncritical variations provided a crude yellow foam. |
T518 | 418-561 | Sentence | denotes | This material was purified by Biotage MPLC (25 M column, 5–6% methanol/chloroform) to afford 82 mg (35%) of the title compound as a white foam. |
T519 | 562-1093 | Sentence | denotes | 1H NMR (DMSO-d6) δ 11.57 (s, 1H), 8.42 (d, J = 8 Hz, 1H), 8.38 (d, J = 8 Hz, 1H), 7.62 (s, 1H), 7.35 (s, 1H), 7.09 (t, J = 8 Hz, 1H), 6.99 (d, J = 8 Hz, 1H), 6.49 (d, J = 8 Hz, 1H), 5.06 (t, J = 8 Hz, 1H), 4.44 (m, 2H), 4.25 (dd, J = 8, 20 Hz, 1H), 4.14 (dd, J = 8, 20 Hz, 1H), 3.87 (s, 3H), 3.08 (m, 2H), 2.28 (m, 1H), 2.10 (m, 1H), 1.91 (m, 1H), 1.74–1.54 (m, 4H), 1.32 (m, 4H), 0.87 (t, J = 8 Hz, 3H); MS (ESI+) for C24H32N4O6m/z 473.2 (M + H)+; anal. calcd for C24H32N4O6·0.6 H2O·0.2 ethyl acetate: C, 59.46; H, 7.01; N, 11.18. |
T520 | 1094-1191 | Sentence | denotes | Found: C, 53.37; H, 6.94; N, 11.23; HRMS (ESI+) calcd for C24H32N4O6+H1 473.2395, found 473.2382. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1747 | 480-488 | Chemical | denotes | methanol | MESH:D000432 |
1748 | 489-499 | Chemical | denotes | chloroform | MESH:D002725 |
1749 | 1027-1037 | Chemical | denotes | C24H32N4O6 | |
1750 | 1042-1045 | Chemical | denotes | H2O | |
1751 | 1050-1063 | Chemical | denotes | ethyl acetate | MESH:C007650 |
1752 | 1065-1066 | Chemical | denotes | C | MESH:D002244 |
1753 | 1084-1085 | Chemical | denotes | N | MESH:D009584 |
1754 | 1101-1102 | Chemical | denotes | C | MESH:D002244 |
1755 | 1120-1121 | Chemical | denotes | N | MESH:D009584 |
1756 | 1152-1162 | Chemical | denotes | C24H32N4O6 | |
1757 | 1130-1134 | Disease | denotes | HRMS |