PMC:7571312 / 88118-89192
Annnotations
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T627 | 376-377 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T628 | 492-503 | http://purl.obolibrary.org/obo/CLO_0007699 | denotes | mg (63%) of |
T629 | 492-503 | http://purl.obolibrary.org/obo/CLO_0050808 | denotes | mg (63%) of |
T630 | 933-935 | http://purl.obolibrary.org/obo/CLO_0007874 | denotes | MS |
T631 | 971-976 | http://purl.obolibrary.org/obo/CLO_0007706 | denotes | M + H |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T1569 | 77-83 | Chemical | denotes | chloro | http://purl.obolibrary.org/obo/CHEBI_47853 |
T1570 | 86-89 | Chemical | denotes | oxo | http://purl.obolibrary.org/obo/CHEBI_46629 |
T1571 | 120-126 | Chemical | denotes | methyl | http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309 |
T1573 | 127-133 | Chemical | denotes | propyl | http://purl.obolibrary.org/obo/CHEBI_26308 |
T1574 | 134-139 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
T1575 | 140-148 | Chemical | denotes | carbonyl | http://purl.obolibrary.org/obo/CHEBI_23019 |
T1576 | 150-163 | Chemical | denotes | 3-methylbutyl | http://purl.obolibrary.org/obo/CHEBI_30359 |
T1577 | 167-174 | Chemical | denotes | methoxy | http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520 |
T1579 | 175-184 | Chemical | denotes | 1H-indole | http://purl.obolibrary.org/obo/CHEBI_16881 |
T1580 | 175-177 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1581 | 178-184 | Chemical | denotes | indole | http://purl.obolibrary.org/obo/CHEBI_35581 |
T1582 | 187-198 | Chemical | denotes | carboxamide | http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622 |
T1584 | 216-218 | Chemical | denotes | N2 | http://purl.obolibrary.org/obo/CHEBI_17997 |
T1585 | 220-239 | Chemical | denotes | tert-butoxycarbonyl | http://purl.obolibrary.org/obo/CHEBI_48502 |
T1586 | 252-258 | Chemical | denotes | chloro | http://purl.obolibrary.org/obo/CHEBI_47853 |
T1587 | 261-264 | Chemical | denotes | oxo | http://purl.obolibrary.org/obo/CHEBI_46629 |
T1588 | 295-301 | Chemical | denotes | methyl | http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309 |
T1590 | 302-308 | Chemical | denotes | propyl | http://purl.obolibrary.org/obo/CHEBI_26308 |
T1591 | 457-465 | Chemical | denotes | methanol | http://purl.obolibrary.org/obo/CHEBI_17790 |
T1592 | 466-476 | Chemical | denotes | chloroform | http://purl.obolibrary.org/obo/CHEBI_35255 |
T1593 | 546-548 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1594 | 554-558 | Chemical | denotes | DMSO | http://purl.obolibrary.org/obo/CHEBI_28262 |
T1595 | 575-577 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1596 | 599-601 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1597 | 623-625 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1598 | 637-639 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1599 | 651-653 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1600 | 675-677 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1601 | 699-701 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1602 | 723-725 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1603 | 748-750 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1604 | 773-775 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1605 | 787-789 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1606 | 801-803 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1607 | 843-845 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1608 | 857-859 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T1609 | 871-873 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T43246 | 933-935 | Chemical | denotes | MS | http://purl.obolibrary.org/obo/CHEBI_73613 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T512 | 0-396 | Sentence | denotes | Following the procedure described for the preparation of N-((1S)-1-{[((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-1H-indole-2-carboxamide but substituting N2-(tert-butoxycarbonyl)-N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-l-norleucinamide and making no other critical variations provided a crude yellow foam. |
T513 | 397-545 | Sentence | denotes | This material was purified by Biotage MPLC (25 M column, 3% methanol/chloroform) to afford 254 mg (63%) of the title compound as an off-white solid. |
T514 | 546-1038 | Sentence | denotes | 1H NMR (DMSO-d6) δ 11.56 (s, 1H), 8.57 (d, J = 8 Hz, 1H), 8.39 (d, J = 4 Hz, 1H), 7.62 (s, 1H), 7.36 (s, 1H), 7.08 (t, J = 8 Hz, 1H), 6.99 (d, J = 8 Hz, 1H), 6.49 (d, J = 8 Hz, 1H), 4.58 (d, J = 16 Hz, 1H), 4.56 (d, J = 16 Hz, 1H), 4.43 (m, 1H), 4.35 (m, 1H), 3.87 (s, 3H), 3.09 (m, 2H), 2.27 (m, 1H), 2.08 (m, 1H), 1.97 (m, 1H), 1.74–1.54 (m, 4H), 1.30 (m, 4H), 0.86 (t, J = 8 Hz, 3H); MS (ESI+) for C24H31N4O5Cl m/z 491.1 (M + H)+; anal. calcd for C24H31ClN4O5: C, 58.71; H, 6.36; N, 11.41. |
T515 | 1039-1074 | Sentence | denotes | Found: C, 58.66; H, 6.45; N, 11.22. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1729 | 457-465 | Chemical | denotes | methanol | MESH:D000432 |
1730 | 466-476 | Chemical | denotes | chloroform | MESH:D002725 |
1731 | 996-1008 | Chemical | denotes | C24H31ClN4O5 | |
1732 | 1010-1011 | Chemical | denotes | C | MESH:D002244 |
1733 | 1029-1030 | Chemical | denotes | N | MESH:D009584 |
1734 | 1046-1047 | Chemical | denotes | C | MESH:D002244 |
1735 | 1065-1066 | Chemical | denotes | N | MESH:D009584 |