> top > docs > PMC:7571312 > spans > 85939-87083 > annotations

PMC:7571312 / 85939-87083 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T615 214-223 http://purl.obolibrary.org/obo/CLO_0007923 denotes N-{(1S)-1
T616 581-582 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T617 732-733 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T618 1097-1099 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T619 1105-1107 http://purl.obolibrary.org/obo/CLO_0053755 denotes ES
T620 1136-1141 http://purl.obolibrary.org/obo/CLO_0007706 denotes M – H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1458 30-33 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1459 64-70 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1461 71-77 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1462 78-83 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1463 84-92 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T1464 94-107 Chemical denotes 3-methylbutyl http://purl.obolibrary.org/obo/CHEBI_30359
T1465 111-118 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1467 121-127 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1469 128-137 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1470 128-130 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1471 131-137 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1472 140-151 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1474 254-261 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T1475 264-267 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1476 298-304 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1478 305-311 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1479 312-317 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1480 319-329 Chemical denotes 2-oxoethyl http://purl.obolibrary.org/obo/CHEBI_46886
T1481 333-340 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1483 341-350 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1484 341-343 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1485 344-350 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1486 353-364 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1488 416-419 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1489 450-456 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1491 457-463 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1492 464-469 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1493 470-478 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T1494 480-493 Chemical denotes 3-methylbutyl http://purl.obolibrary.org/obo/CHEBI_30359
T1495 497-504 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1497 507-513 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1499 514-523 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1500 514-516 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1501 517-523 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1502 526-537 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1504 675-683 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T1505 684-699 Chemical denotes dichloromethane http://purl.obolibrary.org/obo/CHEBI_15767
T1506 758-760 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1507 775-780 Chemical denotes CDCl3 http://purl.obolibrary.org/obo/CHEBI_85365
T1508 794-796 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1509 808-810 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1510 834-836 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1511 860-862 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1512 886-888 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1513 912-914 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1514 926-928 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1515 945-947 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1516 964-966 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1517 1035-1037 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1518 1054-1056 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1519 1097-1099 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T1520 1105-1107 Chemical denotes ES http://purl.obolibrary.org/obo/CHEBI_73509

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T502 0-156 Sentence denotes N-((1S)-1-{[((1S)-3-Hydroxy-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-N-methyl-1H-indole-2-carboxamide (38)
T503 157-601 Sentence denotes Following the procedure described for the preparation of N-{(1S)-1-(cyclohexylmethyl)-2-[((1S)-3-hydroxy-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]-2-oxoethyl}-4-methoxy-1H-indole-2-carboxamide but substituting N-((1S)-1-{[((1S)-3-(benzyloxy)-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-N-methyl-1H-indole-2-carboxamide and making noncritical variations provided a crude clear glass.
T504 602-757 Sentence denotes This material was purified by Biotage flash chromatography, eluting with methanol/dichloromethane to afford the title compound as a white foam, 42 mg, 82%.
T505 758-1144 Sentence denotes 1H NMR (400 MHz, CDCl3) δ 10.16 (s, 1H), 8.26 (s, 1H), 7.18 (t, J = 8.0 Hz, 1H), 7.05 (d, J = 8.1 Hz, 1H), 6.99 (d, J = 2.3 Hz, 1H), 6.48 (d, J = 7.6 Hz, 1H), 6.09 (s, 1H), 5.14–5.27 (m, 1H), 4.51–4.65 (m, 1H), 4.25–4.50 (m, 2H), 3.94 (s, 3H), 3.26–3.46 (m, 3H), 3.11–3.24 (m, 1H), 3.01–3.11 (m, 1H), 1.48–2.39 (m, 9H), 0.88–1.02 (m, 6H); MS (API-ES–-) for C25H34N4O6m/z 485.3 (M – H)−.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1700 675-683 Chemical denotes methanol MESH:D000432
1701 684-699 Chemical denotes dichloromethane MESH:D008752