> top > docs > PMC:7571312 > spans > 78940-80759 > annotations

PMC:7571312 / 78940-80759 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T584 406-407 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T585 559-560 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T586 574-576 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T587 609-614 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H
T588 690-699 http://purl.obolibrary.org/obo/CLO_0007923 denotes N-{(1S)-1
T589 1052-1053 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T590 1196-1197 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T591 1616-1618 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T592 1651-1656 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1128 77-84 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T1129 87-90 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1130 121-127 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1132 128-134 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1133 135-140 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1134 141-149 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T1135 151-164 Chemical denotes 3-methylbutyl http://purl.obolibrary.org/obo/CHEBI_30359
T1136 168-175 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1138 176-185 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1139 176-178 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1140 179-185 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1141 188-199 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1143 237-243 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T1144 246-249 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1145 280-286 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1147 287-293 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1148 294-299 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1149 300-308 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T17569 331-338 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1152 339-348 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1153 339-341 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1154 342-348 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1155 351-362 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1157 490-498 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T1158 499-509 Chemical denotes chloroform http://purl.obolibrary.org/obo/CHEBI_35255
T1159 574-576 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T1160 730-737 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T1161 740-743 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1162 774-780 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1164 781-787 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1165 788-793 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1166 795-805 Chemical denotes 2-oxoethyl http://purl.obolibrary.org/obo/CHEBI_46886
T1167 809-816 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1169 817-826 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1170 817-819 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1171 820-826 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1172 829-840 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1174 892-895 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1175 926-932 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1177 933-939 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1178 940-945 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1179 946-954 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T1180 977-984 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1182 985-994 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1183 985-987 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1184 988-994 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1185 997-1008 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1187 1127-1135 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T1188 1136-1146 Chemical denotes chloroform http://purl.obolibrary.org/obo/CHEBI_35255
T1189 1211-1213 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1190 1219-1223 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T1191 1240-1242 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1192 1264-1266 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1193 1288-1290 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1194 1302-1304 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1195 1316-1318 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1196 1340-1342 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1197 1364-1366 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1198 1388-1390 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1199 1412-1414 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1200 1426-1428 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1201 1440-1442 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1202 1469-1471 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1203 1498-1500 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1204 1540-1542 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1205 1554-1556 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1206 1568-1570 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1207 1597-1599 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1208 1616-1618 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T1209 1691-1694 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T474 0-426 Sentence denotes Following the procedure described for the preparation of N-((1S)-1-{[((1S)-3-hydroxy-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-1H-indole-2-carboxamide but substituting N-((1S)-1-{[((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3,3-dimethylbutyl)-4-methoxy-1H-indole-2-carboxamide and making noncritical variations provided a crude brown glass.
T475 427-573 Sentence denotes This material was purified by Biotage MPLC (40 M column, 2–10% methanol/chloroform) to afford 415 mg (53%) of the title compound as a white solid.
T476 574-617 Sentence denotes MS (ESI+) for C25H34N4O6m/z 487.2 (M + H)+.
T477 618-1064 Sentence denotes Alternatively, following the procedure described for the preparation of N-{(1S)-1-(cyclohexylmethyl)-2-[((1S)-3-hydroxy-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]-2-oxoethyl}-4-methoxy-1H-indole-2-carboxamide but substituting N-((1S)-1-{[((1S)-3-(benzyloxy)-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3,3-dimethylbutyl)-4-methoxy-1H-indole-2-carboxamide and making noncritical variations provided a tan solid.
T478 1065-1210 Sentence denotes This material was purified by Biotage MPLC (25 M column, 6–7% methanol/chloroform) to afford 100 mg (77%) of the title compound as a white solid.
T479 1211-1724 Sentence denotes 1H NMR (DMSO-d6) δ 11.58 (s, 1H), 8.42 (d, J = 8 Hz, 1H), 8.37 (d, J = 8 Hz, 1H), 7.62 (s, 1H), 7.32 (s, 1H), 7.08 (t, J = 8 Hz, 1H), 6.99 (d, J = 8 Hz, 1H), 6.49 (d, J = 8 Hz, 1H), 5.04 (t, J = 8 Hz, 1H), 4.52 (m, 1H), 4.42 (m, 1H), 4.24 (dd, J = 8, 20 Hz, 1H), 4.12 (dd, J = 8, 20 Hz, 1H), 3.87 (s, 3H), 3.09 (m, 2H), 2.25 (m, 1H), 2.06 (m, 1H), 1.93 (m, 1H), 1.80 (dd, J = 8, 16 Hz, 1H), 0.93 (s, 9H); MS (ESI+) for C25H34N4O6m/z 487.2 (M + H)+; anal. calcd for C25H34N4O6·0.3 H2O: C, 61.03; H, 7.09; N, 11.39.
T480 1725-1819 Sentence denotes Found: C, 61.07; H, 7.09; N, 11.22; HRMS (ESI+) calcd for C25H34N4O6 487.2551, found 487.2541.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1655 490-498 Chemical denotes methanol MESH:D000432
1656 499-509 Chemical denotes chloroform MESH:D002725
1657 588-599 Chemical denotes C25H34N4O6m
1658 1127-1135 Chemical denotes methanol MESH:D000432
1659 1136-1146 Chemical denotes chloroform MESH:D002725
1660 1676-1686 Chemical denotes C25H34N4O6
1661 1691-1694 Chemical denotes H2O
1662 1696-1697 Chemical denotes C MESH:D002244
1663 1715-1716 Chemical denotes N MESH:D009584
1664 1732-1733 Chemical denotes C MESH:D002244
1665 1751-1752 Chemical denotes N MESH:D009584
1666 1783-1793 Chemical denotes C25H34N4O6
1667 1761-1765 Disease denotes HRMS