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PMC:7571312 / 77716-78786 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T579 376-377 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T580 968-970 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T581 1005-1010 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H
T582 1037-1042 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1073 77-83 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T1074 86-89 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1075 120-126 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1077 127-133 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1078 134-139 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1079 140-148 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T1080 150-163 Chemical denotes 3-methylbutyl http://purl.obolibrary.org/obo/CHEBI_30359
T1081 167-174 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1083 175-184 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1084 175-177 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1085 178-184 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1086 187-198 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1088 216-218 Chemical denotes N2 http://purl.obolibrary.org/obo/CHEBI_17997
T1089 220-239 Chemical denotes tert-butoxycarbonyl http://purl.obolibrary.org/obo/CHEBI_48502
T1090 252-258 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T1091 261-264 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1092 295-301 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1094 302-308 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1095 312-318 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1097 461-469 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T1098 470-480 Chemical denotes chloroform http://purl.obolibrary.org/obo/CHEBI_35255
T1099 549-551 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1100 566-570 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T1101 599-601 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1102 625-627 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1103 651-653 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1104 665-667 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1105 691-693 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1106 717-719 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1107 743-745 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1108 769-771 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1109 788-790 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1110 859-861 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1111 878-880 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1112 897-899 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1113 930-932 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1114 968-970 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T470 0-396 Sentence denotes Following the procedure described for the preparation of N-((1S)-1-{[((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-1H-indole-2-carboxamide but substituting N2-(tert-butoxycarbonyl)-N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-4-methyl-l-leucinamide and making noncritical variations provided a pale yellow solid.
T471 397-548 Sentence denotes This material was purified by Biotage MPLC (40 M column, 2–4.5% methanol/chloroform) to afford 920 g (60%) of the title compound as an off-white solid.
T472 549-1070 Sentence denotes 1H NMR (400 MHz, DMSO-d6) δ 11.59 (d, J = 1.8 Hz, 1H), 8.54 (d, J = 7.8 Hz, 1H), 8.45 (d, J = 8.1 Hz, 1H), 7.64 (s, 1H), 7.32 (d, J = 1.8 Hz, 1H), 7.08 (t, J = 8.0 Hz, 1H), 7.00 (d, J = 8.3 Hz, 1H), 6.49 (d, J = 7.6 Hz, 1H), 4.52–4.62 (m, 1H), 4.40–4.51 (m, 2H), 3.87 (s, 3H), 3.01–3.16 (m, 2H), 2.19–2.31 (m, 1H), 2.03–2.12 (m, 1H), 1.91–2.01 (m, 1H), 1.81 (dd, J = 14.1, 9.9 Hz, 1H), 1.54–1.72 (m, 3H), 0.93 (s, 9H); MS (ESI+) for C25H33ClN4O5m/z 505.1 (M + H)+; HRMS (ESI+) calcd for (M + H)+ 505.2212, found 505.2204.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1638 461-469 Chemical denotes methanol MESH:D000432
1639 470-480 Chemical denotes chloroform MESH:D002725
1640 1014-1018 Disease denotes HRMS
1641 922-928 CellLine denotes 9.9 Hz CVCL:Z676