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PMC:7571312 / 76301-77563 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T574 152-154 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T575 550-551 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T576 1046-1048 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T577 1081-1086 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1009 34-37 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1010 68-74 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1012 75-81 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1013 82-87 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1014 88-96 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T1015 119-126 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1017 127-136 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1018 127-129 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1019 130-136 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1020 139-150 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1022 246-249 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1023 280-286 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1025 287-293 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1026 294-299 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T1027 322-332 Chemical denotes 2-oxoethyl http://purl.obolibrary.org/obo/CHEBI_46886
T1028 336-343 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T1030 344-353 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1031 344-346 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1032 347-353 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T1033 356-367 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T1035 410-413 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T1036 444-450 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1038 451-457 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T1039 459-461 Chemical denotes N2 http://purl.obolibrary.org/obo/CHEBI_17997
T1040 463-482 Chemical denotes tert-butoxycarbonyl http://purl.obolibrary.org/obo/CHEBI_48502
T1041 486-492 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T1043 626-634 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T1044 635-645 Chemical denotes chloroform http://purl.obolibrary.org/obo/CHEBI_35255
T1045 714-716 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1046 731-735 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T1047 752-754 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1048 794-796 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1049 832-834 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1050 856-858 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1051 880-882 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1052 894-896 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1053 938-940 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1054 980-982 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1055 994-996 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1056 1008-1010 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T1057 1046-1048 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T1058 1122-1130 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T1059 1136-1139 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T464 0-155 Sentence denotes N-((1S)-1-{[((1S)-3-(Benzyloxy)-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3,3-dimethylbutyl)-4-methoxy-1H-indole-2-carboxamide (34)
T465 156-565 Sentence denotes Following the procedure described for the preparation of N-[(1S)-2-[((1S)-3-(benzyloxy)-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]-4-methoxy-1H-indole-2-carboxamide but substituting N1-((1S)-3-(benzyloxy)-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-N2-(tert-butoxycarbonyl)-4-methyl-l-leucinamide and making noncritical variations provided a golden syrup.
T466 566-713 Sentence denotes This material was purified by Biotage MPLC (25 M column, 3% methanol/chloroform) to afford 173 mg (60%) of the title compound as an off-white foam.
T467 714-1168 Sentence denotes 1H NMR (400 MHz, DMSO-d6) δ 11.58 (s, 1H), 8.43 (app t, J = 8 Hz, 2H), 7.62 (s, 1H), 7.32 (m, 6H), 7.08 (t, J = 8 Hz, 1H), 7.00 (d, J = 8 Hz, 1H), 6.49 (d, J = 8 Hz, 1H), 4.52 (m, 1H), 4.47–4.35 (m, 4H), 4.22 (d, J = 16 Hz, 1H), 3.87 (s, 3H), 3.05 (m, 2H), 2.28 (m, 1H), 2.06 (m, 1H), 1.93 (m, 1H), 1.64–1.57 (m, 3H), 0.92 (s, 9H); MS (ESI+) for C32H40N4O6m/z 577.2 (M + H)+; anal. calcd for C32H40N4O6·0.33 methanol·0.25 H2O: C, 65.62; H, 7.13; N, 9.47.
T468 1169-1262 Sentence denotes Found: C, 65.65; H, 6.90; N, 9.58; HRMS (ESI+) calcd for C32H40N4O6 577.3021, found 577.3001.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1623 626-634 Chemical denotes methanol MESH:D000432
1624 635-645 Chemical denotes chloroform MESH:D002725
1625 1106-1116 Chemical denotes C32H40N4O6
1626 1122-1130 Chemical denotes methanol MESH:D000432
1627 1136-1139 Chemical denotes H2O
1628 1141-1142 Chemical denotes C MESH:D002244
1629 1160-1161 Chemical denotes N MESH:D009584
1630 1176-1177 Chemical denotes C MESH:D002244
1631 1195-1196 Chemical denotes N MESH:D009584
1632 1226-1236 Chemical denotes C32H40N4O6
1633 1204-1208 Disease denotes HRMS