PMC:7571312 / 74642-75404 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7571312","sourcedb":"PMC","sourceid":"7571312","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7571312","text":"Following the procedure described for the preparation of N2-(tert-butoxycarbonyl)-N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-l-leucinamide but substituting Boc-(β t-butyl)-Ala-OH and making noncritical variations provided a golden syrup. This material was purified by Biotage MPLC (65i column, 2.5–3.5% methanol/chloroform) to afford 3.41 g (40%) of the title compound as a white foam. 1H NMR (DMSO-d6) δ 8.39 (d, J = 8 Hz, 1H), 7.64 (s, 1H), 7.00 (d, J = 8 Hz, 1H), 4.58 (d, J = 16 Hz, 1H), 4.52 (d, J = 16 Hz, 1H), 4.38 (m, 1H), 3.92 (m, 1H), 3.15 (t, J = 8 Hz, 1H), 3.07 (q, J = 8 Hz, 1H), 2.22 (m, 1H), 2.09 (m, 1H), 1.97 (m, 1H), 1.62 (m, 2H), 1.50 (m, 2H), 1.36 (s, 9H), 0.88 (s, 9H); MS (ESI+) for C20H34ClN3O6m/z 432.1 (M + H)+.","tracks":[{"project":"LitCovid-PD-CLO","denotations":[{"id":"T565","span":{"begin":248,"end":249},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T566","span":{"begin":398,"end":399},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T567","span":{"begin":717,"end":719},"obj":"http://purl.obolibrary.org/obo/CLO_0007874"},{"id":"T568","span":{"begin":754,"end":759},"obj":"http://purl.obolibrary.org/obo/CLO_0007706"}],"attributes":[{"subj":"T565","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T566","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T567","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T568","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T30108","span":{"begin":57,"end":59},"obj":"Chemical"},{"id":"T11556","span":{"begin":61,"end":80},"obj":"Chemical"},{"id":"T12506","span":{"begin":93,"end":99},"obj":"Chemical"},{"id":"T55873","span":{"begin":102,"end":105},"obj":"Chemical"},{"id":"T74812","span":{"begin":136,"end":142},"obj":"Chemical"},{"id":"T31730","span":{"begin":143,"end":149},"obj":"Chemical"},{"id":"T950","span":{"begin":182,"end":185},"obj":"Chemical"},{"id":"T63866","span":{"begin":189,"end":196},"obj":"Chemical"},{"id":"T60099","span":{"begin":191,"end":196},"obj":"Chemical"},{"id":"T54817","span":{"begin":198,"end":201},"obj":"Chemical"},{"id":"T955","span":{"begin":329,"end":337},"obj":"Chemical"},{"id":"T956","span":{"begin":338,"end":348},"obj":"Chemical"},{"id":"T957","span":{"begin":412,"end":414},"obj":"Chemical"},{"id":"T958","span":{"begin":420,"end":424},"obj":"Chemical"},{"id":"T959","span":{"begin":450,"end":452},"obj":"Chemical"},{"id":"T960","span":{"begin":464,"end":466},"obj":"Chemical"},{"id":"T961","span":{"begin":488,"end":490},"obj":"Chemical"},{"id":"T962","span":{"begin":513,"end":515},"obj":"Chemical"},{"id":"T963","span":{"begin":538,"end":540},"obj":"Chemical"},{"id":"T964","span":{"begin":552,"end":554},"obj":"Chemical"},{"id":"T965","span":{"begin":566,"end":568},"obj":"Chemical"},{"id":"T966","span":{"begin":590,"end":592},"obj":"Chemical"},{"id":"T967","span":{"begin":614,"end":616},"obj":"Chemical"},{"id":"T968","span":{"begin":628,"end":630},"obj":"Chemical"},{"id":"T969","span":{"begin":642,"end":644},"obj":"Chemical"},{"id":"T970","span":{"begin":656,"end":658},"obj":"Chemical"},{"id":"T971","span":{"begin":717,"end":719},"obj":"Chemical"}],"attributes":[{"id":"A59762","pred":"chebi_id","subj":"T30108","obj":"http://purl.obolibrary.org/obo/CHEBI_17997"},{"id":"A42422","pred":"chebi_id","subj":"T11556","obj":"http://purl.obolibrary.org/obo/CHEBI_48502"},{"id":"A13732","pred":"chebi_id","subj":"T12506","obj":"http://purl.obolibrary.org/obo/CHEBI_47853"},{"id":"A96493","pred":"chebi_id","subj":"T55873","obj":"http://purl.obolibrary.org/obo/CHEBI_46629"},{"id":"A59157","pred":"chebi_id","subj":"T74812","obj":"http://purl.obolibrary.org/obo/CHEBI_32875"},{"id":"A26578","pred":"chebi_id","subj":"T74812","obj":"http://purl.obolibrary.org/obo/CHEBI_29309"},{"id":"A4538","pred":"chebi_id","subj":"T31730","obj":"http://purl.obolibrary.org/obo/CHEBI_26308"},{"id":"A80661","pred":"chebi_id","subj":"T950","obj":"http://purl.obolibrary.org/obo/CHEBI_48502"},{"id":"A47407","pred":"chebi_id","subj":"T63866","obj":"http://purl.obolibrary.org/obo/CHEBI_30355"},{"id":"A24135","pred":"chebi_id","subj":"T60099","obj":"http://purl.obolibrary.org/obo/CHEBI_41264"},{"id":"A16033","pred":"chebi_id","subj":"T54817","obj":"http://purl.obolibrary.org/obo/CHEBI_16977"},{"id":"A954","pred":"chebi_id","subj":"T54817","obj":"http://purl.obolibrary.org/obo/CHEBI_46217"},{"id":"A955","pred":"chebi_id","subj":"T955","obj":"http://purl.obolibrary.org/obo/CHEBI_17790"},{"id":"A956","pred":"chebi_id","subj":"T956","obj":"http://purl.obolibrary.org/obo/CHEBI_35255"},{"id":"A957","pred":"chebi_id","subj":"T957","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A958","pred":"chebi_id","subj":"T958","obj":"http://purl.obolibrary.org/obo/CHEBI_28262"},{"id":"A959","pred":"chebi_id","subj":"T959","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A960","pred":"chebi_id","subj":"T960","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A961","pred":"chebi_id","subj":"T961","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A962","pred":"chebi_id","subj":"T962","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A963","pred":"chebi_id","subj":"T963","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A964","pred":"chebi_id","subj":"T964","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A965","pred":"chebi_id","subj":"T965","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A966","pred":"chebi_id","subj":"T966","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A967","pred":"chebi_id","subj":"T967","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A968","pred":"chebi_id","subj":"T968","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A969","pred":"chebi_id","subj":"T969","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A970","pred":"chebi_id","subj":"T970","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A971","pred":"chebi_id","subj":"T971","obj":"http://purl.obolibrary.org/obo/CHEBI_73613"},{"subj":"T30108","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11556","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12506","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T55873","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T74812","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T31730","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T950","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T63866","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T60099","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T54817","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T955","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T956","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T957","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T958","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T959","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T960","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T961","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T962","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T963","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T964","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T965","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T966","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T967","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T968","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T969","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T970","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T971","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T457","span":{"begin":0,"end":263},"obj":"Sentence"},{"id":"T458","span":{"begin":264,"end":411},"obj":"Sentence"},{"id":"T459","span":{"begin":412,"end":762},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T457","pred":"source","obj":"LitCovid-sentences"},{"subj":"T458","pred":"source","obj":"LitCovid-sentences"},{"subj":"T459","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1601","span":{"begin":182,"end":185},"obj":"Gene"},{"id":"1602","span":{"begin":329,"end":337},"obj":"Chemical"},{"id":"1603","span":{"begin":338,"end":348},"obj":"Chemical"}],"attributes":[{"id":"A1601","pred":"tao:has_database_id","subj":"1601","obj":"Gene:91653"},{"id":"A1602","pred":"tao:has_database_id","subj":"1602","obj":"MESH:D000432"},{"id":"A1603","pred":"tao:has_database_id","subj":"1603","obj":"MESH:D002725"},{"subj":"1601","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1602","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1603","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-CLO","color":"#ec93c9","default":true},{"id":"LitCovid-PD-CHEBI","color":"#93e3ec"},{"id":"LitCovid-sentences","color":"#ecdb93"},{"id":"LitCovid-PubTator","color":"#c193ec"}]}]}}