PMC:7571312 / 74520-75404
Annnotations
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T565 | 370-371 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T566 | 520-521 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T567 | 839-841 | http://purl.obolibrary.org/obo/CLO_0007874 | denotes | MS |
T568 | 876-881 | http://purl.obolibrary.org/obo/CLO_0007706 | denotes | M + H |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T13099 | 0-2 | Chemical | denotes | N2 | http://purl.obolibrary.org/obo/CHEBI_17997 |
T68219 | 36-42 | Chemical | denotes | chloro | http://purl.obolibrary.org/obo/CHEBI_47853 |
T99043 | 45-48 | Chemical | denotes | oxo | http://purl.obolibrary.org/obo/CHEBI_46629 |
T91353 | 79-85 | Chemical | denotes | methyl | http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309 |
T62725 | 86-92 | Chemical | denotes | propyl | http://purl.obolibrary.org/obo/CHEBI_26308 |
T37317 | 96-102 | Chemical | denotes | methyl | http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309 |
T30108 | 179-181 | Chemical | denotes | N2 | http://purl.obolibrary.org/obo/CHEBI_17997 |
T11556 | 183-202 | Chemical | denotes | tert-butoxycarbonyl | http://purl.obolibrary.org/obo/CHEBI_48502 |
T12506 | 215-221 | Chemical | denotes | chloro | http://purl.obolibrary.org/obo/CHEBI_47853 |
T55873 | 224-227 | Chemical | denotes | oxo | http://purl.obolibrary.org/obo/CHEBI_46629 |
T74812 | 258-264 | Chemical | denotes | methyl | http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309 |
T31730 | 265-271 | Chemical | denotes | propyl | http://purl.obolibrary.org/obo/CHEBI_26308 |
T950 | 304-307 | Chemical | denotes | Boc | http://purl.obolibrary.org/obo/CHEBI_48502 |
T63866 | 311-318 | Chemical | denotes | t-butyl | http://purl.obolibrary.org/obo/CHEBI_30355 |
T60099 | 313-318 | Chemical | denotes | butyl | http://purl.obolibrary.org/obo/CHEBI_41264 |
T54817 | 320-323 | Chemical | denotes | Ala | http://purl.obolibrary.org/obo/CHEBI_16977|http://purl.obolibrary.org/obo/CHEBI_46217 |
T955 | 451-459 | Chemical | denotes | methanol | http://purl.obolibrary.org/obo/CHEBI_17790 |
T956 | 460-470 | Chemical | denotes | chloroform | http://purl.obolibrary.org/obo/CHEBI_35255 |
T957 | 534-536 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T958 | 542-546 | Chemical | denotes | DMSO | http://purl.obolibrary.org/obo/CHEBI_28262 |
T959 | 572-574 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T960 | 586-588 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T961 | 610-612 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T962 | 635-637 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T963 | 660-662 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T964 | 674-676 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T965 | 688-690 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T966 | 712-714 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T967 | 736-738 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T968 | 750-752 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T969 | 764-766 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T970 | 778-780 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T971 | 839-841 | Chemical | denotes | MS | http://purl.obolibrary.org/obo/CHEBI_73613 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T456 | 0-121 | Sentence | denotes | N2-(tert-Butoxycarbonyl)-N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-4-methyl-l-leucinamide (32) |
T457 | 122-385 | Sentence | denotes | Following the procedure described for the preparation of N2-(tert-butoxycarbonyl)-N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-l-leucinamide but substituting Boc-(β t-butyl)-Ala-OH and making noncritical variations provided a golden syrup. |
T458 | 386-533 | Sentence | denotes | This material was purified by Biotage MPLC (65i column, 2.5–3.5% methanol/chloroform) to afford 3.41 g (40%) of the title compound as a white foam. |
T459 | 534-884 | Sentence | denotes | 1H NMR (DMSO-d6) δ 8.39 (d, J = 8 Hz, 1H), 7.64 (s, 1H), 7.00 (d, J = 8 Hz, 1H), 4.58 (d, J = 16 Hz, 1H), 4.52 (d, J = 16 Hz, 1H), 4.38 (m, 1H), 3.92 (m, 1H), 3.15 (t, J = 8 Hz, 1H), 3.07 (q, J = 8 Hz, 1H), 2.22 (m, 1H), 2.09 (m, 1H), 1.97 (m, 1H), 1.62 (m, 2H), 1.50 (m, 2H), 1.36 (s, 9H), 0.88 (s, 9H); MS (ESI+) for C20H34ClN3O6m/z 432.1 (M + H)+. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
1601 | 304-307 | Gene | denotes | Boc | Gene:91653 |
1602 | 451-459 | Chemical | denotes | methanol | MESH:D000432 |
1603 | 460-470 | Chemical | denotes | chloroform | MESH:D002725 |