> top > docs > PMC:7571312 > spans > 73223-74518 > annotations

PMC:7571312 / 73223-74518 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T560 527-528 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T561 623-624 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T562 740-741 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T563 1085-1087 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T564 1121-1126 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T69025 26-41 Chemical denotes tetrahydrofuran http://purl.obolibrary.org/obo/CHEBI_26911
T50605 58-64 Chemical denotes leucyl http://purl.obolibrary.org/obo/CHEBI_32630|http://purl.obolibrary.org/obo/CHEBI_37904
T10099 65-70 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T892 74-77 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T87185 107-112 Chemical denotes butyl http://purl.obolibrary.org/obo/CHEBI_41264
T50783 210-217 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T55467 218-231 Chemical denotes 1H-indol-2-yl http://purl.obolibrary.org/obo/CHEBI_51611
T26971 218-220 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T95635 232-240 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T46198 244-250 Chemical denotes leucyl http://purl.obolibrary.org/obo/CHEBI_32630|http://purl.obolibrary.org/obo/CHEBI_37904
T12400 251-256 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T17502 260-263 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T68028 293-306 Chemical denotes butyl acetate http://purl.obolibrary.org/obo/CHEBI_31328
T79654 293-298 Chemical denotes butyl http://purl.obolibrary.org/obo/CHEBI_41264
T4229 299-306 Chemical denotes acetate http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622
T88027 335-341 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T908 344-347 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T16652 378-384 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T19988 385-391 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T62244 395-401 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T21601 402-404 Chemical denotes N2 http://purl.obolibrary.org/obo/CHEBI_17997
T90197 411-426 Chemical denotes tetrahydrofuran http://purl.obolibrary.org/obo/CHEBI_26911
T96677 459-483 Chemical denotes 2,6-dichlorobenzoic acid http://purl.obolibrary.org/obo/CHEBI_48623
T23465 479-483 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T76208 637-641 Chemical denotes MeCN http://purl.obolibrary.org/obo/CHEBI_38472
T43038 658-662 Chemical denotes AcOH http://purl.obolibrary.org/obo/CHEBI_15366
T85290 666-671 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T76232 688-692 Chemical denotes AcOH http://purl.obolibrary.org/obo/CHEBI_15366
T922 763-765 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T30289 780-784 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T924 810-812 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T66446 834-836 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T86069 848-850 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T34148 900-902 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T89634 919-921 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T70943 933-935 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T43516 952-954 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T76066 971-973 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T58831 1009-1011 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T87003 1085-1087 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T27881 1163-1166 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T449 0-137 Sentence denotes (3S)-3-({4-Methyl-N-[(2R)-tetrahydrofuran-2-ylcarbonyl]-l-leucyl}amino)-2-oxo-4-[(3S)-2-oxopyrrolidin-3-yl]butyl 2,6-Dichlorobenzoate (3)
T450 138-549 Sentence denotes Following the procedure described for the preparation of (3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-l-leucyl}amino)-2-oxo-4-[(3S)-2-oxopyrrolidin-3-yl]butyl acetate but substituting N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-4-methyl-N2-[(2R)-tetrahydrofuran-2-ylcarbonyl]-l-leucinamide and 2,6-dichlorobenzoic acid and making noncritical variations provided a light amber residue.
T451 550-762 Sentence denotes The residue was purified by preparative HPLC (Luna 10μ C18) eluting with a gradient of MeCN containing 0.1% AcOH in water containing 0.1% AcOH to give 0.155 g (54%) of the title compound as a cream colored solid.
T452 763-1128 Sentence denotes 1H NMR (300 MHz, DMSO-d6) δ 8.52 (d, J = 8 Hz, 1H), 7.79 (d, J = 8 Hz, 1H), 7.71 (s, 1H), 7.66–7.55 (m, 3H), 5.18 (s, 2H), 4.54–4.40 (m, 1H), 4.37–4.35 (m, 1H), 4.25 (m, 1H), 3.98–3.91 (m, 1H), 3.84–3.72 (m, 1H), 3.23–3.07 (m, 2H), 2.33–2.23 (m, 1H), 2.16–2.05 (m, 2H), 1.86–1.74 (m, 3H), 1.72–1.62 (m, 5H), 0.89 (s, 9H); MS (ESI+) for C27H35Cl2N3O7m/z 584 (M + H).
T453 1129-1195 Sentence denotes Anal. calcd for C27H35Cl2N3O7·0.5 H2O: C, 54.64; H, 6.11; N, 7.08.
T454 1196-1230 Sentence denotes Found: C, 54.26; H, 6.00; N, 6.87.
T455 1231-1295 Sentence denotes HRMS (ESI+) calcd for C27H35Cl2N3O7+H1 584.1925, found 584.1921.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1585 596-608 Gene denotes Luna 10μ C18 Gene:27241
1586 637-641 Chemical denotes MeCN
1587 658-662 Chemical denotes AcOH
1588 666-671 Chemical denotes water MESH:D014867
1589 688-692 Chemical denotes AcOH
1590 1145-1158 Chemical denotes C27H35Cl2N3O7
1591 1163-1166 Chemical denotes H2O
1592 1168-1169 Chemical denotes C MESH:D002244
1593 1187-1188 Chemical denotes N MESH:D009584
1594 1203-1204 Chemical denotes C MESH:D002244
1595 1222-1223 Chemical denotes N MESH:D009584
1596 1253-1266 Chemical denotes C27H35Cl2N3O7
1597 1231-1235 Disease denotes HRMS