> top > docs > PMC:7571312 > spans > 71997-73221 > annotations

PMC:7571312 / 71997-73221 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T556 534-535 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T557 604-607 http://purl.obolibrary.org/obo/CLO_0001302 denotes 3–4
T558 1017-1019 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T559 1055-1060 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T56900 12-14 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T99865 15-27 Chemical denotes Benzimidazol http://purl.obolibrary.org/obo/CHEBI_36622
T33937 44-50 Chemical denotes leucyl http://purl.obolibrary.org/obo/CHEBI_32630|http://purl.obolibrary.org/obo/CHEBI_37904
T96959 51-56 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T3582 60-63 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T93827 93-98 Chemical denotes butyl http://purl.obolibrary.org/obo/CHEBI_41264
T56185 202-208 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T13156 211-214 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T9056 245-251 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T66361 252-258 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T6884 259-264 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T73915 265-273 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T16806 275-288 Chemical denotes 3-methylbutyl http://purl.obolibrary.org/obo/CHEBI_30359
T4138 292-299 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T857 300-309 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T1150 300-302 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T68704 303-309 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T94522 312-323 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T73856 353-372 Chemical denotes tert-butoxycarbonyl http://purl.obolibrary.org/obo/CHEBI_48502
T863 376-382 Chemical denotes leucyl http://purl.obolibrary.org/obo/CHEBI_32630|http://purl.obolibrary.org/obo/CHEBI_37904
T23817 383-388 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T56409 392-395 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T34890 425-430 Chemical denotes butyl http://purl.obolibrary.org/obo/CHEBI_41264
T868 431-451 Chemical denotes 2,6-dichlorobenzoate http://purl.obolibrary.org/obo/CHEBI_48624
T54365 456-490 Chemical denotes 1H-benzimidazole-2-carboxylic acid http://purl.obolibrary.org/obo/CHEBI_46117
T58462 456-472 Chemical denotes 1H-benzimidazole http://purl.obolibrary.org/obo/CHEBI_41275
T80761 456-458 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T84904 459-472 Chemical denotes benzimidazole http://purl.obolibrary.org/obo/CHEBI_36622
T45612 475-490 Chemical denotes carboxylic acid http://purl.obolibrary.org/obo/CHEBI_33575
T87122 486-490 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T875 609-617 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T89803 618-633 Chemical denotes dichloromethane http://purl.obolibrary.org/obo/CHEBI_15767
T51988 701-703 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T54835 709-713 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T33731 730-732 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T92838 754-756 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T88564 778-780 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T60324 802-804 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T97684 855-857 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T80754 880-882 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T35133 922-924 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T60607 950-952 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T65260 1017-1019 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T442 0-124 Sentence denotes (3S)-3-{[N-(1H-Benzimidazol-2-ylcarbonyl)-l-leucyl]amino}-2-oxo-4-[(3S)-2-oxopyrrolidin-3-yl]butyl 2,6-Dichlorobenzoate (31)
T443 125-553 Sentence denotes Following the procedure described for the preparation of N-((1S)-1-{[((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-1H-indole-2-carboxamide but substituting (3S)-3-{[N-(tert-butoxycarbonyl)-l-leucyl]amino}-2-oxo-4-[(3S)-2-oxopyrrolidin-3-yl]butyl 2,6-dichlorobenzoate and 1H-benzimidazole-2-carboxylic acid and making noncritical variations provided a crude yellow oil.
T444 554-700 Sentence denotes This material was purified by Biotage MPLC (25 M, 3–4% methanol/dichloromethane) to afford 95 mg (72%) of the title compound as an off-white foam.
T445 701-1063 Sentence denotes 1H NMR (DMSO-d6) δ 13.32 (s, 1H), 8.89 (d, J = 8 Hz, 1H), 8.60 (d, J = 8 Hz, 1H), 7.74 (d, J = 8 Hz, 1H), 7.59 (m, 5H), 7.29 (m, 2H), 5.20 (d, J = 20 Hz, 1H), 5.15 (d, J = 20 Hz, 1H), 4.56 (m, 2H), 3.12 (m, 2H), 2.30 (m, 1H), 2.01 (m, 2H), 1.83 (m, 1H), 1.65 (m, 4H), 0.92 (d, J = 8 Hz, 3H), 0.89 (d, J = 8 Hz, 3H); MS (ESI+) for C29H31Cl2N5O6m/z 616.0 (M + H)+.
T446 1064-1123 Sentence denotes Anal. calcd for C29H31Cl2N5O6: C, 56.50; H, 5.07; N, 11.36.
T447 1124-1159 Sentence denotes Found: C, 57.28; H, 5.32; N, 11.35.
T448 1160-1224 Sentence denotes HRMS (ESI+) calcd for C29H31Cl2N5O6+H1 616.1724, found 616.1729.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1563 609-617 Chemical denotes methanol MESH:D000432
1564 618-633 Chemical denotes dichloromethane MESH:D008752
1565 1080-1093 Chemical denotes C29H31Cl2N5O6
1566 1095-1096 Chemical denotes C MESH:D002244
1567 1114-1115 Chemical denotes N MESH:D009584
1568 1131-1132 Chemical denotes C MESH:D002244
1569 1150-1151 Chemical denotes N MESH:D009584
1570 1182-1195 Chemical denotes C29H31Cl2N5O6
1571 1160-1164 Disease denotes HRMS