> top > docs > PMC:7571312 > spans > 67285-68238 > annotations

PMC:7571312 / 67285-68238 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T529 0-1 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T530 281-282 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T531 516-517 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T532 842-844 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T96207 2-10 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T684 14-24 Chemical denotes tert-butyl http://purl.obolibrary.org/obo/CHEBI_30355
T8989 19-24 Chemical denotes butyl http://purl.obolibrary.org/obo/CHEBI_41264
T686 33-38 Chemical denotes bromo http://purl.obolibrary.org/obo/CHEBI_22927|http://purl.obolibrary.org/obo/CHEBI_47265
T45200 41-44 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T8478 75-81 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T36282 82-88 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T83154 89-98 Chemical denotes carbamate http://purl.obolibrary.org/obo/CHEBI_13941
T693 121-124 Chemical denotes DMF http://purl.obolibrary.org/obo/CHEBI_17741
T46336 150-174 Chemical denotes 2,6-dichlorobenzoic acid http://purl.obolibrary.org/obo/CHEBI_48623
T695 170-174 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T75958 206-212 Chemical denotes cesium http://purl.obolibrary.org/obo/CHEBI_30514
T97736 213-221 Chemical denotes fluoride http://purl.obolibrary.org/obo/CHEBI_17051
T90033 384-397 Chemical denotes ethyl acetate http://purl.obolibrary.org/obo/CHEBI_27750
T15643 384-389 Chemical denotes ethyl http://purl.obolibrary.org/obo/CHEBI_37807|http://purl.obolibrary.org/obo/CHEBI_62801
T94319 390-397 Chemical denotes acetate http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622
T39328 425-430 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T81342 474-479 Chemical denotes MgSO4 http://purl.obolibrary.org/obo/CHEBI_32599
T22666 593-601 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T74066 602-617 Chemical denotes dichloromethane http://purl.obolibrary.org/obo/CHEBI_15767
T31384 688-690 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T85312 705-709 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T67067 753-755 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T72314 781-783 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T711 795-797 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T90477 809-811 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T98218 842-844 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T65368 884-886 Chemical denotes Na http://purl.obolibrary.org/obo/CHEBI_26708

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T415 0-241 Sentence denotes A solution of tert-butyl ((1S)-3-bromo-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)carbamate (1.17 g, 3.2 mmol) in DMF (16 mL) was treated with 2,6-dichlorobenzoic acid (794 mg, 4.2 mmol) followed by cesium fluoride (1.18 g, 7.4 mmol).
T416 242-319 Sentence denotes The resulting suspension was placed in a preheated oil bath at 65 °C for 2 h.
T417 320-537 Sentence denotes The reaction was cooled to an ambient temperature, diluted with ethyl acetate (100 mL), washed once with water (40 mL) and with brine (40 mL), dried over MgSO4, filtered, and concentrated to give a crude yellow syrup.
T418 538-687 Sentence denotes This material was purified by Biotage MPLC (25 M, 4.5% methanol/dichloromethane) to afford 1.19 mg (80%) of the title compound as an off-white glass.
T419 688-953 Sentence denotes 1H NMR (400 MHz, DMSO-d6) δ 7.60 (m, 5H), 5.35 (s, 2H), 4.32 (m, 1H), 3.23 (m, 2H), 2.24 (m, 1H), 2.11 (m, 1H), 1.86 (m, 1H), 1.67 (m, 2H), 1.35 (s, 9H); MS (ESI+) for C20H24Cl2N2O6m/z 481.0 (M + Na)+; HRMS (ESI+) calcd for C20H24Cl2N2O6+H 481.0903, found 481.0890.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1464 14-98 Chemical denotes tert-butyl ((1S)-3-bromo-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)carbamate
1465 121-124 Chemical denotes DMF MESH:D004126
1466 150-174 Chemical denotes 2,6-dichlorobenzoic acid
1467 206-221 Chemical denotes cesium fluoride MESH:C027754
1468 293-296 Chemical denotes oil MESH:D009821
1469 384-397 Chemical denotes ethyl acetate MESH:C007650
1470 425-430 Chemical denotes water MESH:D014867
1471 448-453 Chemical denotes brine MESH:C017082
1472 474-479 Chemical denotes MgSO4 MESH:D008278
1473 593-601 Chemical denotes methanol MESH:D000432
1474 602-617 Chemical denotes dichloromethane MESH:D008752
1475 890-894 Disease denotes HRMS