> top > docs > PMC:7571312 > spans > 50115-51216 > annotations

PMC:7571312 / 50115-51216 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T470 390-391 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T471 949-953 http://purl.obolibrary.org/obo/CLO_0050298 denotes 10 H
T472 956-958 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T473 991-996 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T65519 23-36 Chemical denotes 1H-indol-2-yl http://purl.obolibrary.org/obo/CHEBI_51611
T62787 23-25 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T2814 37-45 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T48 49-55 Chemical denotes leucyl http://purl.obolibrary.org/obo/CHEBI_32630|http://purl.obolibrary.org/obo/CHEBI_37904
T39064 56-61 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T28301 65-68 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T28169 98-103 Chemical denotes butyl http://purl.obolibrary.org/obo/CHEBI_41264
T28986 104-127 Chemical denotes Cyclopropanecarboxylate http://purl.obolibrary.org/obo/CHEBI_36128
T33097 205-212 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T33354 213-226 Chemical denotes 1H-indol-2-yl http://purl.obolibrary.org/obo/CHEBI_51611
T39869 213-215 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T80612 227-235 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T99831 239-245 Chemical denotes leucyl http://purl.obolibrary.org/obo/CHEBI_32630|http://purl.obolibrary.org/obo/CHEBI_37904
T99405 246-251 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T74190 255-258 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T23544 288-301 Chemical denotes butyl acetate http://purl.obolibrary.org/obo/CHEBI_31328
T69104 288-293 Chemical denotes butyl http://purl.obolibrary.org/obo/CHEBI_41264
T82668 294-301 Chemical denotes acetate http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622
T47617 319-346 Chemical denotes cyclopropanecarboxylic acid http://purl.obolibrary.org/obo/CHEBI_23500
T89669 342-346 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T69 466-474 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T92205 475-490 Chemical denotes dichloromethane http://purl.obolibrary.org/obo/CHEBI_15767
T96218 537-539 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T94620 554-558 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T58187 587-589 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T39205 613-615 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T91620 639-641 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T22421 653-655 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T65323 679-681 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T99169 705-707 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T60504 724-726 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T19823 750-752 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T81 764-766 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T77212 783-785 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T18933 854-856 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T91104 873-875 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T26339 892-894 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T70916 956-958 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T6246 1032-1035 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T329 0-132 Sentence denotes (3S)-3-({N-[(4-Methoxy-1H-indol-2-yl)carbonyl]-l-leucyl}amino)-2-oxo-4-[(3S)-2-oxopyrrolidin-3-yl]butyl Cyclopropanecarboxylate (14)
T330 133-406 Sentence denotes Following the procedure described for the preparation of (3S)-3-({N-[(4-methoxy-1H-indol-2-yl)carbonyl]-l-leucyl}amino)-2-oxo-4-[(3S)-2-oxopyrrolidin-3-yl]butyl acetate but substituting cyclopropanecarboxylic acid and making noncritical variations provided a crude product.
T331 407-536 Sentence denotes This material was purified by Biotage MPLC (25 M, 2.5–4.5% methanol/dichloromethane) to afford 82 mg (43%) of the title compound.
T332 537-999 Sentence denotes 1H NMR (400 MHz, DMSO-d6) δ 11.57 (d, J = 2.0 Hz, 1H), 8.56 (d, J = 7.8 Hz, 1H), 8.43 (d, J = 7.6 Hz, 1H), 7.63 (s, 1H), 7.36 (d, J = 1.5 Hz, 1H), 7.08 (t, J = 8.0 Hz, 1H), 6.97–7.02 (m, 1H), 6.49 (d, J = 7.6 Hz, 1H), 4.85 (d, 1H), 4.78–4.96 (m, 1H), 4.33–4.51 (m, 2H), 3.87 (s, 3H), 3.02–3.16 (m, 2H), 2.22–2.35 (m, 1H), 2.01–2.11 (m, 1H), 1.89–2.00 (m, 1H), 1.65–1.77 (m, 3H), 1.46–1.65 (m, 3H), 0.81–0.98 (m, 10 H); MS (ESI+) for C28H36N4O7m/z 541.2 (M + H)+.
T333 1000-1065 Sentence denotes Anal. calcd for C28H36N4O7·0.59 H2O: C, 61.01; H, 6.80; N, 10.16.
T334 1066-1101 Sentence denotes Found: C, 61.04; H, 6.72; N, 10.00.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1163 319-346 Chemical denotes cyclopropanecarboxylic acid MESH:C015766
1164 466-474 Chemical denotes methanol MESH:D000432
1165 475-490 Chemical denotes dichloromethane MESH:D008752
1166 1016-1026 Chemical denotes C28H36N4O7
1167 1032-1035 Chemical denotes H2O
1168 1037-1038 Chemical denotes C MESH:D002244
1169 1056-1057 Chemical denotes N MESH:D009584
1170 1073-1074 Chemical denotes C MESH:D002244
1171 1092-1093 Chemical denotes N MESH:D009584