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PMC:7571312 / 44482-45395 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T431 83-84 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T432 339-340 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T433 528-529 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T434 671-672 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T435 869-871 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T436 905-910 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T792 23-29 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T793 41-57 Chemical denotes pyrrolidin-2-one http://purl.obolibrary.org/obo/CHEBI_36592
T794 59-72 Chemical denotes Hydrochloride http://purl.obolibrary.org/obo/CHEBI_17883
T795 85-93 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T796 97-107 Chemical denotes tert-butyl http://purl.obolibrary.org/obo/CHEBI_30355
T797 102-107 Chemical denotes butyl http://purl.obolibrary.org/obo/CHEBI_41264
T798 116-121 Chemical denotes diazo http://purl.obolibrary.org/obo/CHEBI_30105
T799 124-127 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T800 158-164 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T802 165-171 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T803 173-182 Chemical denotes carbamate http://purl.obolibrary.org/obo/CHEBI_13941
T804 205-216 Chemical denotes 1,4-dioxane http://purl.obolibrary.org/obo/CHEBI_47032
T805 209-216 Chemical denotes dioxane http://purl.obolibrary.org/obo/CHEBI_46923
T806 258-260 Chemical denotes N2 http://purl.obolibrary.org/obo/CHEBI_17997
T807 304-312 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T808 341-349 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T809 357-374 Chemical denotes hydrochloric acid http://purl.obolibrary.org/obo/CHEBI_17883
T810 370-374 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T811 378-389 Chemical denotes 1,4-dioxane http://purl.obolibrary.org/obo/CHEBI_47032
T812 382-389 Chemical denotes dioxane http://purl.obolibrary.org/obo/CHEBI_46923
T813 600-613 Chemical denotes diethyl ether http://purl.obolibrary.org/obo/CHEBI_35702
T814 608-613 Chemical denotes ether http://purl.obolibrary.org/obo/CHEBI_25698
T815 687-689 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T816 695-699 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T817 730-732 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T818 755-757 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T819 780-782 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T820 794-796 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T821 822-824 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T822 836-838 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T823 864-866 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T824 869-871 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T38 515-524 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T298 0-82 Sentence denotes (3S)-3-[(2S)-2-Amino-4-chloro-3-oxobutyl]pyrrolidin-2-one, Hydrochloride Salt (10)
T299 83-280 Sentence denotes A solution of tert-butyl ((1S)-3-diazo-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl) carbamate (592 mg, 2.0 mmol) in 1,4-dioxane (7 mL) was placed under an atmosphere of N2 and cooled to 0 °C.
T300 281-442 Sentence denotes This clear pale yellow solution was dropwise treated with a solution of 4 M hydrochloric acid in 1,4-dioxane (5 mL, 20 mmol) with copious gas evolution observed.
T301 443-548 Sentence denotes Upon complete addition, the reaction was warmed to RT over 1 h with the formation of a white precipitate.
T302 549-686 Sentence denotes The solid was collected by filtration, washed with diethyl ether, and dried to give 401 mg (83%) of the title compound as a white powder.
T303 687-913 Sentence denotes 1H NMR (DMSO-d6) δ 8.76 (bs, 3H), 7.96 (s, 1H), 4.93 (d, J = 16 Hz, 1H), 4.80 (d, J = 16 Hz, 1H), 4.28 (m, 1H), 3.18 (m, 2H), 2.61 (m, 1H), 2.30 (m, 1H), 1.93 (m, 2H), 1.70 (m, 1H); MS (ESI+) for C8H13ClN2O2m/z 205.0 (M + H)+.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1067 0-77 Chemical denotes (3S)-3-[(2S)-2-Amino-4-chloro-3-oxobutyl]pyrrolidin-2-one, Hydrochloride Salt
1069 600-613 Chemical denotes diethyl ether MESH:D004986