> top > docs > PMC:7571312 > spans > 24520-25754 > annotations

PMC:7571312 / 24520-25754 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T89000 893-897 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 893-897 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T66 61-65 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T241 89-90 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T242 233-235 http://purl.obolibrary.org/obo/CLO_0008285 denotes P1
T243 257-258 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T244 291-292 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T245 380-381 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T246 507-508 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T247 762-763 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T248 819-820 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T249 976-977 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T250 1115-1116 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T399 125-132 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T401 165-171 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T403 206-214 Chemical denotes hydroxyl http://purl.obolibrary.org/obo/CHEBI_29191|http://purl.obolibrary.org/obo/CHEBI_43176
T405 233-235 Chemical denotes P1 http://purl.obolibrary.org/obo/CHEBI_60949
T406 293-301 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T407 307-312 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T408 353-361 Chemical denotes hydroxyl http://purl.obolibrary.org/obo/CHEBI_29191|http://purl.obolibrary.org/obo/CHEBI_43176
T410 382-390 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T411 509-517 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T412 523-528 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T413 573-581 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T414 604-610 Chemical denotes proton http://purl.obolibrary.org/obo/CHEBI_24636
T415 737-746 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T416 785-793 Chemical denotes hydroxyl http://purl.obolibrary.org/obo/CHEBI_29191|http://purl.obolibrary.org/obo/CHEBI_43176
T418 821-829 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T419 835-843 Chemical denotes acceptor http://purl.obolibrary.org/obo/CHEBI_15339
T420 853-859 Chemical denotes proton http://purl.obolibrary.org/obo/CHEBI_24636
T421 929-937 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T422 947-955 Chemical denotes hydroxyl http://purl.obolibrary.org/obo/CHEBI_29191|http://purl.obolibrary.org/obo/CHEBI_43176
T424 978-986 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T425 992-997 Chemical denotes donor http://purl.obolibrary.org/obo/CHEBI_17891
T426 1005-1013 Chemical denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555
T427 1085-1088 Chemical denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T428 1093-1101 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T429 1127-1137 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T430 1219-1233 Chemical denotes hydroxyl group http://purl.obolibrary.org/obo/CHEBI_43176
T431 1219-1227 Chemical denotes hydroxyl http://purl.obolibrary.org/obo/CHEBI_29191
T432 1228-1233 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T25 694-705 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T154 0-176 Sentence denotes An examination of the crystal structure of 2 in complex with SARS CoV-1 3CLpro suggested a limited functional role for the 4-methoxy substituent contained in the P3 indole cap.
T155 177-313 Sentence denotes Additionally, the terminal α-hydroxyl moiety located at P1′ appeared to provide a potential opportunity to remove a hydrogen bond donor.
T156 314-473 Sentence denotes Although it was anticipated that the α-hydroxyl moiety would form a hydrogen bond to the catalytic His41, the directionality of this interaction was uncertain.
T157 474-706 Sentence denotes As noted earlier, His41 presents a hydrogen bond donor to the interior of the protease, leaving an acceptor to participate in the proton transfer cycling from neutral to cationic in the putative catalytic mechanism44 of proteolysis.
T158 707-879 Sentence denotes If His41 is protonated in the inhibitor-bound complex, a lone pair from the α-hydroxyl moiety would function as a hydrogen bond acceptor from the proton on the His residue.
T159 880-1043 Sentence denotes On the other hand, if His41 is deprotonated, the hydrogen of the α-hydroxyl moiety would act as a hydrogen bond donor to the nitrogen lone pair of the His residue.
T160 1044-1234 Sentence denotes Consistent with the strategy to decrease PSA and hydrogen bond donors, a series of inhibitors were prepared that contained alterations to the P3 cap and substitution of the α-hydroxyl group.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
608 61-69 Species denotes SARS CoV Tax:694009
609 293-301 Chemical denotes hydrogen MESH:D006859
610 382-390 Chemical denotes hydrogen MESH:D006859
611 413-418 Chemical denotes His41
612 509-517 Chemical denotes hydrogen MESH:D006859
613 710-715 Chemical denotes His41
614 821-829 Chemical denotes hydrogen MESH:D006859
615 867-870 Chemical denotes His MESH:D006639
616 902-907 Chemical denotes His41
617 929-937 Chemical denotes hydrogen MESH:D006859
618 978-986 Chemical denotes hydrogen MESH:D006859
619 1005-1013 Chemical denotes nitrogen MESH:D009584
620 1031-1034 Chemical denotes His MESH:D006639
621 1093-1101 Chemical denotes hydrogen MESH:D006859

2_test

Id Subject Object Predicate Lexical cue
33054210-15450003-61913458 688-690 15450003 denotes 44