PMC:7571312 / 24520-25754
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T89000 | 893-897 | Body_part | denotes | hand | http://purl.org/sig/ont/fma/fma9712 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T6 | 893-897 | Body_part | denotes | hand | http://purl.obolibrary.org/obo/UBERON_0002398 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T66 | 61-65 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T241 | 89-90 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T242 | 233-235 | http://purl.obolibrary.org/obo/CLO_0008285 | denotes | P1 |
| T243 | 257-258 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T244 | 291-292 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T245 | 380-381 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T246 | 507-508 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T247 | 762-763 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T248 | 819-820 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T249 | 976-977 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T250 | 1115-1116 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T399 | 125-132 | Chemical | denotes | methoxy | http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520 |
| T401 | 165-171 | Chemical | denotes | indole | http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581 |
| T403 | 206-214 | Chemical | denotes | hydroxyl | http://purl.obolibrary.org/obo/CHEBI_29191|http://purl.obolibrary.org/obo/CHEBI_43176 |
| T405 | 233-235 | Chemical | denotes | P1 | http://purl.obolibrary.org/obo/CHEBI_60949 |
| T406 | 293-301 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T407 | 307-312 | Chemical | denotes | donor | http://purl.obolibrary.org/obo/CHEBI_17891 |
| T408 | 353-361 | Chemical | denotes | hydroxyl | http://purl.obolibrary.org/obo/CHEBI_29191|http://purl.obolibrary.org/obo/CHEBI_43176 |
| T410 | 382-390 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T411 | 509-517 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T412 | 523-528 | Chemical | denotes | donor | http://purl.obolibrary.org/obo/CHEBI_17891 |
| T413 | 573-581 | Chemical | denotes | acceptor | http://purl.obolibrary.org/obo/CHEBI_15339 |
| T414 | 604-610 | Chemical | denotes | proton | http://purl.obolibrary.org/obo/CHEBI_24636 |
| T415 | 737-746 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T416 | 785-793 | Chemical | denotes | hydroxyl | http://purl.obolibrary.org/obo/CHEBI_29191|http://purl.obolibrary.org/obo/CHEBI_43176 |
| T418 | 821-829 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T419 | 835-843 | Chemical | denotes | acceptor | http://purl.obolibrary.org/obo/CHEBI_15339 |
| T420 | 853-859 | Chemical | denotes | proton | http://purl.obolibrary.org/obo/CHEBI_24636 |
| T421 | 929-937 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T422 | 947-955 | Chemical | denotes | hydroxyl | http://purl.obolibrary.org/obo/CHEBI_29191|http://purl.obolibrary.org/obo/CHEBI_43176 |
| T424 | 978-986 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T425 | 992-997 | Chemical | denotes | donor | http://purl.obolibrary.org/obo/CHEBI_17891 |
| T426 | 1005-1013 | Chemical | denotes | nitrogen | http://purl.obolibrary.org/obo/CHEBI_25555 |
| T427 | 1085-1088 | Chemical | denotes | PSA | http://purl.obolibrary.org/obo/CHEBI_61599 |
| T428 | 1093-1101 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T429 | 1127-1137 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T430 | 1219-1233 | Chemical | denotes | hydroxyl group | http://purl.obolibrary.org/obo/CHEBI_43176 |
| T431 | 1219-1227 | Chemical | denotes | hydroxyl | http://purl.obolibrary.org/obo/CHEBI_29191 |
| T432 | 1228-1233 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T25 | 694-705 | http://purl.obolibrary.org/obo/GO_0006508 | denotes | proteolysis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T154 | 0-176 | Sentence | denotes | An examination of the crystal structure of 2 in complex with SARS CoV-1 3CLpro suggested a limited functional role for the 4-methoxy substituent contained in the P3 indole cap. |
| T155 | 177-313 | Sentence | denotes | Additionally, the terminal α-hydroxyl moiety located at P1′ appeared to provide a potential opportunity to remove a hydrogen bond donor. |
| T156 | 314-473 | Sentence | denotes | Although it was anticipated that the α-hydroxyl moiety would form a hydrogen bond to the catalytic His41, the directionality of this interaction was uncertain. |
| T157 | 474-706 | Sentence | denotes | As noted earlier, His41 presents a hydrogen bond donor to the interior of the protease, leaving an acceptor to participate in the proton transfer cycling from neutral to cationic in the putative catalytic mechanism44 of proteolysis. |
| T158 | 707-879 | Sentence | denotes | If His41 is protonated in the inhibitor-bound complex, a lone pair from the α-hydroxyl moiety would function as a hydrogen bond acceptor from the proton on the His residue. |
| T159 | 880-1043 | Sentence | denotes | On the other hand, if His41 is deprotonated, the hydrogen of the α-hydroxyl moiety would act as a hydrogen bond donor to the nitrogen lone pair of the His residue. |
| T160 | 1044-1234 | Sentence | denotes | Consistent with the strategy to decrease PSA and hydrogen bond donors, a series of inhibitors were prepared that contained alterations to the P3 cap and substitution of the α-hydroxyl group. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 608 | 61-69 | Species | denotes | SARS CoV | Tax:694009 |
| 609 | 293-301 | Chemical | denotes | hydrogen | MESH:D006859 |
| 610 | 382-390 | Chemical | denotes | hydrogen | MESH:D006859 |
| 611 | 413-418 | Chemical | denotes | His41 | |
| 612 | 509-517 | Chemical | denotes | hydrogen | MESH:D006859 |
| 613 | 710-715 | Chemical | denotes | His41 | |
| 614 | 821-829 | Chemical | denotes | hydrogen | MESH:D006859 |
| 615 | 867-870 | Chemical | denotes | His | MESH:D006639 |
| 616 | 902-907 | Chemical | denotes | His41 | |
| 617 | 929-937 | Chemical | denotes | hydrogen | MESH:D006859 |
| 618 | 978-986 | Chemical | denotes | hydrogen | MESH:D006859 |
| 619 | 1005-1013 | Chemical | denotes | nitrogen | MESH:D009584 |
| 620 | 1031-1034 | Chemical | denotes | His | MESH:D006639 |
| 621 | 1093-1101 | Chemical | denotes | hydrogen | MESH:D006859 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 33054210-15450003-61913458 | 688-690 | 15450003 | denotes | 44 |