
PMC:7571312 / 23427-24519
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T63397 | 126-130 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T53789 | 354-359 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T46 | 381-387 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
T40778 | 419-423 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T47080 | 424-440 | Body_part | denotes | epithelial cells | http://purl.org/sig/ont/fma/fma66768 |
T52254 | 435-440 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T65361 | 579-583 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T97321 | 745-757 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T4 | 381-387 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
T5 | 419-423 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T75668 | 59-60 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T75637 | 126-130 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
T94133 | 260-266 | http://purl.obolibrary.org/obo/CLO_0002172 | denotes | Caco-2 |
T56692 | 260-266 | http://purl.obolibrary.org/obo/CLO_0051943 | denotes | Caco-2 |
T24243 | 260-266 | http://purl.obolibrary.org/obo/CLO_0051958 | denotes | Caco-2 |
T87690 | 260-266 | http://purl.obolibrary.org/obo/CLO_0051960 | denotes | Caco-2 |
T229 | 346-353 | http://purl.obolibrary.org/obo/CLO_0009526 | denotes | Vero 76 |
T230 | 354-359 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T231 | 374-380 | http://purl.obolibrary.org/obo/NCBITaxon_9479 | denotes | monkey |
T232 | 381-387 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
T233 | 381-387 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
T234 | 381-387 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
T235 | 413-418 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T236 | 419-440 | http://purl.obolibrary.org/obo/CL_0000082 | denotes | lung epithelial cells |
T237 | 571-578 | http://purl.obolibrary.org/obo/CLO_0009526 | denotes | Vero 76 |
T238 | 579-588 | http://purl.obolibrary.org/obo/CLO_0000031 | denotes | cell line |
T239 | 664-665 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T240 | 714-720 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T390 | 66-75 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T391 | 163-173 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
T392 | 321-330 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T393 | 492-501 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T394 | 685-694 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T395 | 745-757 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
T396 | 788-797 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
T397 | 935-938 | Chemical | denotes | PSA | http://purl.obolibrary.org/obo/CHEBI_61599 |
T398 | 968-976 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T13 | 223-229 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
T14 | 223-229 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
T15 | 311-317 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
T16 | 311-317 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
T17 | 557-563 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
T18 | 557-563 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
T19 | 704-710 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
T20 | 704-710 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
T21 | 714-733 | http://purl.obolibrary.org/obo/GO_0015291 | denotes | active transporters |
T22 | 743-757 | http://purl.obolibrary.org/obo/GO_0008559 | denotes | P-glycoprotein |
T23 | 1085-1091 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
T24 | 1085-1091 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T148 | 0-144 | Sentence | denotes | The results for 4 and the other examples in Table 3 reveal a high antiviral EC50/enzyme IC50 ratio, which may arise from poor cell permeability. |
T149 | 145-282 | Sentence | denotes | Indeed, these HMK inhibitors exhibit very low permeability and high levels of efflux beyond the sensitivity of the Caco-2 in vitro assay. |
T150 | 283-452 | Sentence | denotes | However, the impact of high efflux on antiviral potencies from Vero 76 cells (derived from monkey kidney) versus disease-relevant human lung epithelial cells is unknown. |
T151 | 453-649 | Sentence | denotes | To better understand the observed high antiviral EC50/enzyme IC50 ratio for 4, we evaluated the role of efflux in the Vero 76 cell line by the in vitro experimental design discussed further below. |
T152 | 650-822 | Sentence | denotes | Concurrently, a strategy to design molecules reducing efflux by active transporters, such as P-glycoprotein, was pursued to decrease high antiviral EC50/enzyme IC50 ratios. |
T153 | 823-1092 | Sentence | denotes | An analysis of the physicochemical properties of 4 suggested that increasing logP, reducing polar surface area (PSA), and reducing the number of hydrogen bond donors/acceptors were design strategies with the potential to improve cellular permeability and reduce efflux. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
590 | 743-757 | Gene | denotes | P-glycoprotein | Gene:5243 |
591 | 413-418 | Species | denotes | human | Tax:9606 |
592 | 260-266 | Chemical | denotes | Caco-2 | |
593 | 968-976 | Chemical | denotes | hydrogen | MESH:D006859 |