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PMC:7571312 / 23427-24519 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T63397 126-130 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T53789 354-359 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T46 381-387 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T40778 419-423 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T47080 424-440 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T52254 435-440 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T65361 579-583 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T97321 745-757 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T4 381-387 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T5 419-423 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T75668 59-60 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T75637 126-130 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T94133 260-266 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco-2
T56692 260-266 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco-2
T24243 260-266 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco-2
T87690 260-266 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco-2
T229 346-353 http://purl.obolibrary.org/obo/CLO_0009526 denotes Vero 76
T230 354-359 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T231 374-380 http://purl.obolibrary.org/obo/NCBITaxon_9479 denotes monkey
T232 381-387 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T233 381-387 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T234 381-387 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T235 413-418 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T236 419-440 http://purl.obolibrary.org/obo/CL_0000082 denotes lung epithelial cells
T237 571-578 http://purl.obolibrary.org/obo/CLO_0009526 denotes Vero 76
T238 579-588 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T239 664-665 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T240 714-720 http://purl.obolibrary.org/obo/CLO_0001658 denotes active

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T390 66-75 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T391 163-173 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T392 321-330 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T393 492-501 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T394 685-694 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T395 745-757 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T396 788-797 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T397 935-938 Chemical denotes PSA http://purl.obolibrary.org/obo/CHEBI_61599
T398 968-976 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T13 223-229 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T14 223-229 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T15 311-317 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T16 311-317 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T17 557-563 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T18 557-563 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T19 704-710 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T20 704-710 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux
T21 714-733 http://purl.obolibrary.org/obo/GO_0015291 denotes active transporters
T22 743-757 http://purl.obolibrary.org/obo/GO_0008559 denotes P-glycoprotein
T23 1085-1091 http://purl.obolibrary.org/obo/GO_0140352 denotes efflux
T24 1085-1091 http://purl.obolibrary.org/obo/GO_0140115 denotes efflux

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T148 0-144 Sentence denotes The results for 4 and the other examples in Table 3 reveal a high antiviral EC50/enzyme IC50 ratio, which may arise from poor cell permeability.
T149 145-282 Sentence denotes Indeed, these HMK inhibitors exhibit very low permeability and high levels of efflux beyond the sensitivity of the Caco-2 in vitro assay.
T150 283-452 Sentence denotes However, the impact of high efflux on antiviral potencies from Vero 76 cells (derived from monkey kidney) versus disease-relevant human lung epithelial cells is unknown.
T151 453-649 Sentence denotes To better understand the observed high antiviral EC50/enzyme IC50 ratio for 4, we evaluated the role of efflux in the Vero 76 cell line by the in vitro experimental design discussed further below.
T152 650-822 Sentence denotes Concurrently, a strategy to design molecules reducing efflux by active transporters, such as P-glycoprotein, was pursued to decrease high antiviral EC50/enzyme IC50 ratios.
T153 823-1092 Sentence denotes An analysis of the physicochemical properties of 4 suggested that increasing logP, reducing polar surface area (PSA), and reducing the number of hydrogen bond donors/acceptors were design strategies with the potential to improve cellular permeability and reduce efflux.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
590 743-757 Gene denotes P-glycoprotein Gene:5243
591 413-418 Species denotes human Tax:9606
592 260-266 Chemical denotes Caco-2
593 968-976 Chemical denotes hydrogen MESH:D006859