PMC:7571312 / 20372-21126
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T16632 | 85-92 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T93878 | 432-436 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T88519 | 576-580 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T60 | 437-446 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T61 | 581-590 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T99824 | 307-312 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T45488 | 340-348 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T66631 | 368-369 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T29691 | 389-394 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T82549 | 432-436 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T68545 | 501-509 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T85347 | 576-580 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T335 | 85-92 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T336 | 130-134 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T337 | 717-727 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T12 | 241-252 | http://purl.obolibrary.org/obo/GO_0006508 | denotes | proteolysis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T129 | 0-220 | Sentence | denotes | Although irreversible inhibition can provide an extended pharmacodynamic effect when protein resynthesis rate is slow compared to drug clearance, such extended effects for 3CLpro inhibition were not necessarily expected. |
| T130 | 221-447 | Sentence | denotes | The 3CLpro-mediated proteolysis of newly expressed viral polyproteins is essential to virus replication; however, this activity only occurs during a single step in the virus life cycle that closely follows each cell infection. |
| T131 | 448-561 | Sentence | denotes | Viral particles themselves are not reliant on 3CLpro activity nor are the remaining coronavirus life cycle steps. |
| T132 | 562-626 | Sentence | denotes | Each event of cell infection initiates newly synthesized 3CLpro. |
| T133 | 627-754 | Sentence | denotes | Because detailed kinetics of this process are not understood, reversible and irreversible inhibitors were investigated equally. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 536 | 532-543 | Species | denotes | coronavirus | Tax:11118 |
| 537 | 172-178 | Chemical | denotes | 3CLpro | |
| 538 | 437-446 | Disease | denotes | infection | MESH:D007239 |
| 539 | 581-590 | Disease | denotes | infection | MESH:D007239 |