PMC:7571312 / 20029-20478 JSONTXT

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Evaluation of the pharmacokinetic profile of 3 in rat suggested that this inhibitor possessed properties potentially sufficient for an IV continuous infusion dosing paradigm.42\nAlthough irreversible inhibition can provide an extended pharmacodynamic effect when protein resynthesis r","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T44316","span":{"begin":74,"end":79},"obj":"Body_part"},{"id":"T16632","span":{"begin":428,"end":435},"obj":"Body_part"}],"attributes":[{"id":"A30322","pred":"fma_id","subj":"T44316","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A91543","pred":"fma_id","subj":"T16632","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T44316","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T16632","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T24511","span":{"begin":4,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0007437"},{"id":"T12434","span":{"begin":4,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0007448"},{"id":"T28200","span":{"begin":4,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0007449"},{"id":"T54715","span":{"begin":4,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0050175"},{"id":"T71311","span":{"begin":4,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0052399"},{"id":"T97946","span":{"begin":8,"end":11},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T96800","span":{"begin":57,"end":65},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T32450","span":{"begin":69,"end":73},"obj":"http://purl.obolibrary.org/obo/CLO_0009524"},{"id":"T14088","span":{"begin":69,"end":73},"obj":"http://purl.obolibrary.org/obo/CLO_0050515"},{"id":"T54297","span":{"begin":74,"end":79},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T91837","span":{"begin":162,"end":164},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"}],"attributes":[{"subj":"T24511","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12434","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T28200","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54715","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T71311","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T97946","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T96800","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T32450","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14088","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T54297","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T91837","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T332","span":{"begin":47,"end":56},"obj":"Chemical"},{"id":"T333","span":{"begin":240,"end":249},"obj":"Chemical"},{"id":"T334","span":{"begin":301,"end":303},"obj":"Chemical"},{"id":"T335","span":{"begin":428,"end":435},"obj":"Chemical"}],"attributes":[{"id":"A332","pred":"chebi_id","subj":"T332","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A333","pred":"chebi_id","subj":"T333","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A334","pred":"chebi_id","subj":"T334","obj":"http://purl.obolibrary.org/obo/CHEBI_74327"},{"id":"A335","pred":"chebi_id","subj":"T335","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T332","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T333","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T334","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T335","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T127","span":{"begin":14,"end":165},"obj":"Sentence"},{"id":"T128","span":{"begin":166,"end":342},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T127","pred":"source","obj":"LitCovid-sentences"},{"subj":"T128","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"528","span":{"begin":216,"end":219},"obj":"Species"}],"attributes":[{"id":"A528","pred":"tao:has_database_id","subj":"528","obj":"Tax:10116"},{"subj":"528","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93a8","default":true},{"id":"LitCovid-PD-CLO","color":"#93c2ec"},{"id":"LitCovid-PD-CHEBI","color":"#dcec93"},{"id":"LitCovid-sentences","color":"#e193ec"},{"id":"LitCovid-PubTator","color":"#93ecc7"}]}]}}