PMC:7571312 / 17892-18715
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T29395 | 156-161 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T77718 | 228-233 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T39660 | 329-334 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T54465 | 405-409 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T44584 | 410-415 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T80152 | 609-615 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T3 | 405-409 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T56 | 85-89 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T35747 | 36-38 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T36376 | 148-155 | http://purl.obolibrary.org/obo/CLO_0009526 | denotes | Vero 76 |
| T60100 | 156-161 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T41307 | 220-227 | http://purl.obolibrary.org/obo/CLO_0009526 | denotes | Vero 76 |
| T44344 | 228-233 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T95747 | 271-279 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T41737 | 324-328 | http://purl.obolibrary.org/obo/CLO_0009524 | denotes | Vero |
| T58120 | 324-328 | http://purl.obolibrary.org/obo/CLO_0050515 | denotes | Vero |
| T23029 | 329-334 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T96607 | 399-404 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T31340 | 405-409 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T79444 | 405-409 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T79987 | 410-415 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T84247 | 455-457 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T92769 | 603-608 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T56673 | 609-615 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T32052 | 633-635 | http://purl.obolibrary.org/obo/CLO_0053794 | denotes | 41 |
| T59638 | 645-647 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T18074 | 657-658 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T19548 | 669-677 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T305 | 4-24 | Chemical | denotes | 2,6-dichlorobenzoate | http://purl.obolibrary.org/obo/CHEBI_48624 |
| T306 | 110-119 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T307 | 261-270 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T308 | 511-523 | Chemical | denotes | nucleophiles | http://purl.obolibrary.org/obo/CHEBI_59740 |
| T309 | 532-543 | Chemical | denotes | glutathione | http://purl.obolibrary.org/obo/CHEBI_16856|http://purl.obolibrary.org/obo/CHEBI_57925 |
| T311 | 744-746 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
| T312 | 805-807 | Chemical | denotes | IV | http://purl.obolibrary.org/obo/CHEBI_74327 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T9 | 289-300 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | translation |
| T10 | 352-358 | http://purl.obolibrary.org/obo/GO_0140352 | denotes | efflux |
| T11 | 352-358 | http://purl.obolibrary.org/obo/GO_0140115 | denotes | efflux |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T116 | 0-441 | Sentence | denotes | The 2,6-dichlorobenzoate derivative 22 displays the highest levels of potency in the SARS CoV-1 3CLpro and in antiviral cytopathic effect assays in Vero 76 cells (EC50 = 0.29 ± 0.19 μM).39 We note here that the assay in Vero 76 cells provided data establishing antiviral activity, but the translation of potency measured in Vero cells, which have high efflux potential, to the potency achievable in human lung cells was unknown (vide infra). |
| T117 | 442-823 | Sentence | denotes | As expected, 22 possesses low levels of reactivity toward endogenous nucleophiles such as glutathione (t1/2 > 60 min)40 and exhibits high levels of stability in human plasma (t1/2 > 240 min).41 Although 22 displays a promising activity profile, it possesses very poor solubility in clinically relevant IV vehicle formulations, thus limiting its development as an IV clinical agent. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 497 | 85-93 | Species | denotes | SARS CoV | Tax:694009 |
| 498 | 399-404 | Species | denotes | human | Tax:9606 |
| 499 | 603-608 | Species | denotes | human | Tax:9606 |
| 500 | 4-24 | Chemical | denotes | 2,6-dichlorobenzoate | |
| 501 | 532-543 | Chemical | denotes | glutathione | MESH:D005978 |