PMC:7571312 / 130682-131645 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T48 156-165 Body_part denotes cellulose http://purl.org/sig/ont/fma/fma82748
T49 456-463 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T211 45-48 http://purl.obolibrary.org/obo/CL_0000784 denotes DC2
T212 100-103 http://purl.obolibrary.org/obo/CL_0000784 denotes DC2
T213 146-147 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T214 383-386 http://purl.obolibrary.org/obo/CLO_0050644 denotes w/v
T215 479-480 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T216 481-484 http://purl.obolibrary.org/obo/CLO_0053733 denotes 1:1
T217 496-497 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T218 647-649 http://purl.obolibrary.org/obo/CLO_0001382 denotes 48
T219 730-731 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T220 879-880 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T221 900-901 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T35035 12-14 Chemical denotes PF http://purl.obolibrary.org/obo/CHEBI_74795|http://purl.obolibrary.org/obo/CHEBI_90284
T35251 156-173 Chemical denotes cellulose acetate http://purl.obolibrary.org/obo/CHEBI_145232
T19137 166-173 Chemical denotes acetate http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622
T67659 336-345 Chemical denotes potassium http://purl.obolibrary.org/obo/CHEBI_26216
T82330 346-352 Chemical denotes sodium http://purl.obolibrary.org/obo/CHEBI_26708
T33318 353-361 Chemical denotes tartrate http://purl.obolibrary.org/obo/CHEBI_132950|http://purl.obolibrary.org/obo/CHEBI_30929|http://purl.obolibrary.org/obo/CHEBI_50562
T22599 387-390 Chemical denotes PEG http://purl.obolibrary.org/obo/CHEBI_46793
T31946 456-463 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T26094 503-509 Chemical denotes buffer http://purl.obolibrary.org/obo/CHEBI_35225
T77705 653-655 Chemical denotes PF http://purl.obolibrary.org/obo/CHEBI_74795|http://purl.obolibrary.org/obo/CHEBI_90284
T76569 674-678 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T55351 679-687 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T99825 843-851 Chemical denotes nitrogen http://purl.obolibrary.org/obo/CHEBI_25555
T70082 907-913 Chemical denotes buffer http://purl.obolibrary.org/obo/CHEBI_35225
T1062 929-937 Chemical denotes glycerol http://purl.obolibrary.org/obo/CHEBI_17754

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T720 0-70 Sentence denotes Crystals of PF-00835231 bound to SARS2/CoV-2 DC2 protease via soaking:
T721 71-267 Sentence denotes Freshly prepared SARS2/CoV-2 DC2 protease at 25.8 mg/mL was passed through a 0.45 mM cellulose acetate spin filter and set up for crystallization using an NT-8 crystallization robot (Formulatrix).
T722 268-510 Sentence denotes Using MRC-2 crystallization plates, wells containing 40 mL of 0.2 M potassium sodium tartrate tetrahydrate and 20% w/v PEG 3350 were dispensed, and then sitting drops consisting of 0.3 μL protein were set up in a 1:1 ratio with a well buffer.
T723 511-652 Sentence denotes Crystallization plates were incubated at 13 °C, and large crystals shaped as beveled plates measuring 0.35 × 0.2 × 0.025 mm3 grew after 48 h.
T724 653-798 Sentence denotes PF-00835231 (in 100% DMSO solution) was introduced to the drop (in situ), at a final concentration of 1 mM, and then incubated at 13 °C for 24 h.
T725 799-938 Sentence denotes Soaked crystals were flash-frozen in liquid nitrogen after being passed through a cryo consisting of a well buffer containing 20% glycerol.
T726 939-963 Sentence denotes Structure determination.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2323 100-103 Gene denotes DC2 Gene:58505
2324 45-48 Gene denotes DC2 Gene:58505
2325 33-38 Species denotes SARS2 Tax:2697049
2326 39-44 Species denotes CoV-2 Tax:2697049
2327 88-93 Species denotes SARS2 Tax:2697049
2328 94-99 Species denotes CoV-2 Tax:2697049
2329 156-173 Chemical denotes cellulose acetate MESH:C005062
2330 336-374 Chemical denotes potassium sodium tartrate tetrahydrate MESH:C029768
2331 387-390 Chemical denotes PEG
2332 674-678 Chemical denotes DMSO MESH:D004121
2333 843-851 Chemical denotes nitrogen MESH:D009584
2334 929-937 Chemical denotes glycerol MESH:D005990
2335 274-279 CellLine denotes MRC-2 CVCL:0440