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PMC:7571312 / 12007-12752 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T93676 0-1 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T62552 114-117 http://purl.obolibrary.org/obo/CLO_0002526 denotes CMK
T38138 152-155 http://purl.obolibrary.org/obo/CLO_0002526 denotes CMK
T5895 263-264 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T91690 344-345 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T7075 400-407 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T97610 427-430 http://purl.obolibrary.org/obo/CLO_0002526 denotes CMK
T35533 471-484 http://purl.obolibrary.org/obo/UBERON_0002329 denotes epimerization
T32370 672-674 http://purl.obolibrary.org/obo/CLO_0008307 denotes P2

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T171 187-194 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T172 311-320 Chemical denotes methylene http://purl.obolibrary.org/obo/CHEBI_29357|http://purl.obolibrary.org/obo/CHEBI_29358|http://purl.obolibrary.org/obo/CHEBI_50728
T175 322-324 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T176 400-407 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T177 523-539 Chemical denotes carboxylic acids http://purl.obolibrary.org/obo/CHEBI_33575
T178 534-539 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T179 559-565 Chemical denotes cesium http://purl.obolibrary.org/obo/CHEBI_30514
T180 566-574 Chemical denotes fluoride http://purl.obolibrary.org/obo/CHEBI_17051
T181 672-674 Chemical denotes P2 http://purl.obolibrary.org/obo/CHEBI_33472
T182 679-684 Chemical denotes amine http://purl.obolibrary.org/obo/CHEBI_32952
T183 722-732 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T61 0-132 Sentence denotes A key element for rapid access to substituted methylketone derivatives was the generation of the fully elaborated CMK 12 (Scheme 2).
T62 133-241 Sentence denotes The utility of the CMK moiety to prepare acyloxy- and hydroxy-substituted methylketones is well established.
T63 242-494 Sentence denotes Elaboration of 10 in a sequence of deprotection/1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU)-mediated peptide couplings provided CMK derivative 12 in moderate yield with no epimerization observed.
T64 495-620 Sentence denotes Reaction of 12 with various carboxylic acids in the presence of cesium fluoride at 60 °C provided acyloxymethylketones 13–28.
T65 621-745 Sentence denotes Using this synthetic approach with substitution of P2 and amine capping structural elements provided inhibitors 3 and 29–31.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
305 46-58 Chemical denotes methylketone MESH:D000096
306 174-220 Chemical denotes acyloxy- and hydroxy-substituted methylketones
307 290-383 Chemical denotes 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate
308 385-389 Chemical denotes HATU MESH:C472082
309 523-539 Chemical denotes carboxylic acids MESH:D002264
310 559-574 Chemical denotes cesium fluoride MESH:C027754
311 593-613 Chemical denotes acyloxymethylketones
312 672-674 Chemical denotes P2 MESH:C020845
313 679-684 Chemical denotes amine MESH:D000588