PMC:7571312 / 12007-12752
Annnotations
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T93676 | 0-1 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T62552 | 114-117 | http://purl.obolibrary.org/obo/CLO_0002526 | denotes | CMK |
| T38138 | 152-155 | http://purl.obolibrary.org/obo/CLO_0002526 | denotes | CMK |
| T5895 | 263-264 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T91690 | 344-345 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
| T7075 | 400-407 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptide |
| T97610 | 427-430 | http://purl.obolibrary.org/obo/CLO_0002526 | denotes | CMK |
| T35533 | 471-484 | http://purl.obolibrary.org/obo/UBERON_0002329 | denotes | epimerization |
| T32370 | 672-674 | http://purl.obolibrary.org/obo/CLO_0008307 | denotes | P2 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T171 | 187-194 | Chemical | denotes | hydroxy | http://purl.obolibrary.org/obo/CHEBI_43176 |
| T172 | 311-320 | Chemical | denotes | methylene | http://purl.obolibrary.org/obo/CHEBI_29357|http://purl.obolibrary.org/obo/CHEBI_29358|http://purl.obolibrary.org/obo/CHEBI_50728 |
| T175 | 322-324 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T176 | 400-407 | Chemical | denotes | peptide | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T177 | 523-539 | Chemical | denotes | carboxylic acids | http://purl.obolibrary.org/obo/CHEBI_33575 |
| T178 | 534-539 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T179 | 559-565 | Chemical | denotes | cesium | http://purl.obolibrary.org/obo/CHEBI_30514 |
| T180 | 566-574 | Chemical | denotes | fluoride | http://purl.obolibrary.org/obo/CHEBI_17051 |
| T181 | 672-674 | Chemical | denotes | P2 | http://purl.obolibrary.org/obo/CHEBI_33472 |
| T182 | 679-684 | Chemical | denotes | amine | http://purl.obolibrary.org/obo/CHEBI_32952 |
| T183 | 722-732 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T61 | 0-132 | Sentence | denotes | A key element for rapid access to substituted methylketone derivatives was the generation of the fully elaborated CMK 12 (Scheme 2). |
| T62 | 133-241 | Sentence | denotes | The utility of the CMK moiety to prepare acyloxy- and hydroxy-substituted methylketones is well established. |
| T63 | 242-494 | Sentence | denotes | Elaboration of 10 in a sequence of deprotection/1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU)-mediated peptide couplings provided CMK derivative 12 in moderate yield with no epimerization observed. |
| T64 | 495-620 | Sentence | denotes | Reaction of 12 with various carboxylic acids in the presence of cesium fluoride at 60 °C provided acyloxymethylketones 13–28. |
| T65 | 621-745 | Sentence | denotes | Using this synthetic approach with substitution of P2 and amine capping structural elements provided inhibitors 3 and 29–31. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 305 | 46-58 | Chemical | denotes | methylketone | MESH:D000096 |
| 306 | 174-220 | Chemical | denotes | acyloxy- and hydroxy-substituted methylketones | |
| 307 | 290-383 | Chemical | denotes | 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate | |
| 308 | 385-389 | Chemical | denotes | HATU | MESH:C472082 |
| 309 | 523-539 | Chemical | denotes | carboxylic acids | MESH:D002264 |
| 310 | 559-574 | Chemical | denotes | cesium fluoride | MESH:C027754 |
| 311 | 593-613 | Chemical | denotes | acyloxymethylketones | |
| 312 | 672-674 | Chemical | denotes | P2 | MESH:C020845 |
| 313 | 679-684 | Chemical | denotes | amine | MESH:D000588 |