PMC:7571312 / 116812-117881 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T4 406-409 Body_part denotes gum http://purl.org/sig/ont/fma/fma59762

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T75 392-393 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T76 406-409 http://www.ebi.ac.uk/efo/EFO_0001925 denotes gum
T77 569-571 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T78 915-917 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T79 951-956 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T93292 77-84 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T39926 87-90 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T24479 121-127 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T71379 128-134 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T38104 135-140 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T90466 141-149 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T61936 151-164 Chemical denotes 3-methylbutyl http://purl.obolibrary.org/obo/CHEBI_30359
T7882 168-175 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T51027 176-185 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T75175 176-178 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T17960 179-185 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T11063 188-199 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T93122 237-243 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T56680 246-249 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T35692 280-286 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T3494 287-293 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T53890 294-299 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T93081 300-308 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T44392 310-323 Chemical denotes 3-methylbutyl http://purl.obolibrary.org/obo/CHEBI_30359
T6187 325-334 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T88828 325-327 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T74900 328-334 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T24081 337-348 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T31330 484-492 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T93828 493-508 Chemical denotes dichloromethane http://purl.obolibrary.org/obo/CHEBI_15767
T71758 574-576 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T75834 591-595 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T43907 612-614 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T16037 683-685 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T83963 697-699 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T20664 723-725 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T83646 749-751 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T76364 763-765 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T45015 839-841 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T28626 872-874 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T25151 915-917 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T36103 992-995 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377
T39479 1001-1004 Chemical denotes DCM http://purl.obolibrary.org/obo/CHEBI_15767

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T628 0-410 Sentence denotes Following the procedure described for the preparation of N-((1S)-1-{[((1S)-3-hydroxy-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-1H-indole-2-carboxamide but substituting N-((1S)-1-{[((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-1H-indole-2-carboxamide and making noncritical variations provided a crude black gum.
T629 411-573 Sentence denotes This material was purified by Biotage flash chromatography, eluting with methanol/dichloromethane to afford the title compound as an off-white solid, 218 mg, 18%.
T630 574-1034 Sentence denotes 1H NMR (400 MHz, DMSO-d6) δ 11.58 (s, 1H), 8.42–8.61 (m, 2H), 7.61 (d, J = 8.6 Hz, 2H), 7.41 (d, J = 8.1 Hz, 1H), 7.26 (s, 1H), 7.17 (t, J = 7.6 Hz, 1H), 7.02 (t, J = 7.5 Hz, 1H), 5.02 (t, 1H), 4.38–4.58 (m, 2H), 4.09–4.32 (m, 2H), 3.01–3.17 (m, 2H), 2.24–2.38 (m, 1H), 2.03–2.22 (m, 2H), 1.92 (m, 1H), 1.46–1.77 (m, 4H), 0.85–0.99 (m, 6H); MS (APCI+) for C23H30N4O5m/z 443.1 (M + H)+; anal. calcd for C23H30N4O5·0.55 H2O·0.05 DCM: C, 60.62; H, 6.89; N, 12.27.
T631 1035-1069 Sentence denotes Found: C, 60.83; H, 6.90; N,11.93.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T11 1001-1004 Phenotype denotes DCM http://purl.obolibrary.org/obo/HP_0001644

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2061 484-492 Chemical denotes methanol MESH:D000432
2062 493-508 Chemical denotes dichloromethane MESH:D008752
2063 976-986 Chemical denotes C23H30N4O5
2064 992-995 Chemical denotes H2O
2065 1001-1004 Chemical denotes DCM MESH:D008752
2066 1006-1007 Chemical denotes C MESH:D002244
2067 1025-1026 Chemical denotes N MESH:D009584
2068 1042-1043 Chemical denotes C MESH:D002244
2069 1061-1062 Chemical denotes N MESH:D009584