PMC:7571312 / 107915-109070 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T38 398-399 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T39 550-551 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 933-935 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T41 968-973 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T42070 59-66 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T19254 87-94 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T21168 97-100 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T78288 131-137 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T70271 138-144 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T30845 145-150 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T34779 151-159 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T15437 177-186 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T15738 177-179 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T25581 180-186 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T22068 189-200 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T83442 238-245 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T17431 248-251 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T41161 282-288 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T36519 289-295 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T61331 296-301 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T47970 302-310 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T449 331-340 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T17365 331-333 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T17081 334-340 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T37575 343-354 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T80084 482-490 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T96119 491-501 Chemical denotes chloroform http://purl.obolibrary.org/obo/CHEBI_35255
T71814 565-567 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T98352 573-577 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T24718 594-596 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T15447 676-678 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T57883 690-692 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T96176 714-716 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T62641 738-740 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T2200 752-754 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T20444 766-768 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T67451 791-793 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T16902 816-818 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T78000 858-860 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T36020 872-874 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T86594 886-888 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T57849 900-902 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T20594 933-935 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T80810 1008-1021 Chemical denotes ethyl acetate http://purl.obolibrary.org/obo/CHEBI_27750
T83883 1008-1013 Chemical denotes ethyl http://purl.obolibrary.org/obo/CHEBI_37807|http://purl.obolibrary.org/obo/CHEBI_62801
T9831 1014-1021 Chemical denotes acetate http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622
T5541 1027-1030 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T593 0-415 Sentence denotes Following the procedure described for the preparation of 4-methoxy-N-((1S)-1-{[((1S)-3-methoxy-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-4-methylpentyl)-1H-indole-2-carboxamide but substituting N-((1S)-1-{[((1S)-3-hydroxy-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3,3-dimethylbutyl)-1H-indole-2-carboxamide and making noncritical variations provided a crude tan foam.
T594 416-564 Sentence denotes This material was purified by Biotage MPLC (25 M column, 3.5–4.5% methanol/chloroform) to afford 43 mg (15%) of the title compound as a white solid.
T595 565-1060 Sentence denotes 1H NMR (DMSO-d6) δ 11.58 (s, 1H), 8.48 (apar t, J = 8 Hz, 2H), 7.61 (apar d, J = 8 Hz, 2H), 7.41 (d, J = 8 Hz, 1H), 7.23 (s, 1H), 7.17 (t, J = 8 Hz, 1H), 7.02 (t, J = 8 Hz, 1H), 4.55 (m, 1H), 4.37 (m, 1H), 4.25 (d, J = 20 Hz, 1H), 4.10 (d, J = 20 Hz, 1H), 3.23 (s, 3H), 3.06 (m, 2H), 2.27 (m, 1H), 2.07 (m, 1H), 1.91 (m, 1H), 1.79 (m, 1H), 1.69 (m, 3H), 0.94 (s, 9H); MS (ESI+) for C25H34N4O5m/z 471.2 (M + H)+; anal. calcd for C25H34N4O5·0.2 ethyl acetate·0.75 H2O: C, 61.76; H, 7.46; N, 11.17.
T596 1061-1155 Sentence denotes Found: C, 61.85; H, 7.15; N, 11.02; HRMS (ESI+) calcd for C25H34N4O5 471.2602, found 471.2595.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1969 482-490 Chemical denotes methanol MESH:D000432
1970 491-501 Chemical denotes chloroform MESH:D002725
1971 993-1003 Chemical denotes C25H34N4O5
1972 1008-1021 Chemical denotes ethyl acetate MESH:C007650
1973 1027-1030 Chemical denotes H2O
1974 1032-1033 Chemical denotes C MESH:D002244
1975 1051-1052 Chemical denotes N MESH:D009584
1976 1068-1069 Chemical denotes C MESH:D002244
1977 1087-1088 Chemical denotes N MESH:D009584
1978 1119-1129 Chemical denotes C25H34N4O5
1979 1097-1101 Disease denotes HRMS