PMC:7571312 / 107773-109070 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T38 540-541 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T39 692-693 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 1075-1077 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T41 1110-1115 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T61187 30-33 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T85968 64-70 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T84117 71-77 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T83483 78-83 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T85382 84-92 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T31472 113-122 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T24322 113-115 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T57403 116-122 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T51067 125-136 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T42070 201-208 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T19254 229-236 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T21168 239-242 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T78288 273-279 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T70271 280-286 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T30845 287-292 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T34779 293-301 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T15437 319-328 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T15738 319-321 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T25581 322-328 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T22068 331-342 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T83442 380-387 Chemical denotes hydroxy http://purl.obolibrary.org/obo/CHEBI_43176
T17431 390-393 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T41161 424-430 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T36519 431-437 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T61331 438-443 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T47970 444-452 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T449 473-482 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T17365 473-475 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T17081 476-482 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T37575 485-496 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T80084 624-632 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T96119 633-643 Chemical denotes chloroform http://purl.obolibrary.org/obo/CHEBI_35255
T71814 707-709 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T98352 715-719 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T24718 736-738 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T15447 818-820 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T57883 832-834 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T96176 856-858 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T62641 880-882 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T2200 894-896 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T20444 908-910 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T67451 933-935 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T16902 958-960 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T78000 1000-1002 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T36020 1014-1016 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T86594 1028-1030 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T57849 1042-1044 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T20594 1075-1077 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T80810 1150-1163 Chemical denotes ethyl acetate http://purl.obolibrary.org/obo/CHEBI_27750
T83883 1150-1155 Chemical denotes ethyl http://purl.obolibrary.org/obo/CHEBI_37807|http://purl.obolibrary.org/obo/CHEBI_62801
T9831 1156-1163 Chemical denotes acetate http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622
T5541 1169-1172 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T592 0-141 Sentence denotes N-((1S)-1-{[((1S)-3-Methoxy-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3,3-dimethylbutyl)-1H-indole-2-carboxamide (44)
T593 142-557 Sentence denotes Following the procedure described for the preparation of 4-methoxy-N-((1S)-1-{[((1S)-3-methoxy-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-4-methylpentyl)-1H-indole-2-carboxamide but substituting N-((1S)-1-{[((1S)-3-hydroxy-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3,3-dimethylbutyl)-1H-indole-2-carboxamide and making noncritical variations provided a crude tan foam.
T594 558-706 Sentence denotes This material was purified by Biotage MPLC (25 M column, 3.5–4.5% methanol/chloroform) to afford 43 mg (15%) of the title compound as a white solid.
T595 707-1202 Sentence denotes 1H NMR (DMSO-d6) δ 11.58 (s, 1H), 8.48 (apar t, J = 8 Hz, 2H), 7.61 (apar d, J = 8 Hz, 2H), 7.41 (d, J = 8 Hz, 1H), 7.23 (s, 1H), 7.17 (t, J = 8 Hz, 1H), 7.02 (t, J = 8 Hz, 1H), 4.55 (m, 1H), 4.37 (m, 1H), 4.25 (d, J = 20 Hz, 1H), 4.10 (d, J = 20 Hz, 1H), 3.23 (s, 3H), 3.06 (m, 2H), 2.27 (m, 1H), 2.07 (m, 1H), 1.91 (m, 1H), 1.79 (m, 1H), 1.69 (m, 3H), 0.94 (s, 9H); MS (ESI+) for C25H34N4O5m/z 471.2 (M + H)+; anal. calcd for C25H34N4O5·0.2 ethyl acetate·0.75 H2O: C, 61.76; H, 7.46; N, 11.17.
T596 1203-1297 Sentence denotes Found: C, 61.85; H, 7.15; N, 11.02; HRMS (ESI+) calcd for C25H34N4O5 471.2602, found 471.2595.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1969 624-632 Chemical denotes methanol MESH:D000432
1970 633-643 Chemical denotes chloroform MESH:D002725
1971 1135-1145 Chemical denotes C25H34N4O5
1972 1150-1163 Chemical denotes ethyl acetate MESH:C007650
1973 1169-1172 Chemical denotes H2O
1974 1174-1175 Chemical denotes C MESH:D002244
1975 1193-1194 Chemical denotes N MESH:D009584
1976 1210-1211 Chemical denotes C MESH:D002244
1977 1229-1230 Chemical denotes N MESH:D009584
1978 1261-1271 Chemical denotes C25H34N4O5
1979 1239-1243 Disease denotes HRMS