PMC:7571312 / 10620-11026 JSONTXT

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T72259","span":{"begin":25,"end":27},"obj":"http://purl.obolibrary.org/obo/CLO_0008285"},{"id":"T79057","span":{"begin":224,"end":226},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T4510","span":{"begin":323,"end":325},"obj":"http://purl.obolibrary.org/obo/CLO_0052906"}],"text":"Scheme 1 Preparation of P1 Synthetic Intermediates\n(i) 3 M NaOH, MeOH (95%), (ii) isobutylchloroformate (IBCF), triethylamine (TEA), tetrahydrofuran (THF), (iii) CH2N2/ether (92%), (iv) 4 M HCl/dioxane (83%), (v) 1.0 equiv 48% HBr (83%), (vi) HNCH3(OCH3), EDC, HOBt, NMM, dichloromethane (DCM) (79%), (vii) Mg, HgCl2, BOM-Cl, THF, −78°C (50%), and (viii) lithium diisopropylamide (LDA), ClCH2I, THF (54%)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T124","span":{"begin":25,"end":27},"obj":"Chemical"},{"id":"T125","span":{"begin":60,"end":64},"obj":"Chemical"},{"id":"T126","span":{"begin":66,"end":70},"obj":"Chemical"},{"id":"T127","span":{"begin":113,"end":126},"obj":"Chemical"},{"id":"T128","span":{"begin":128,"end":131},"obj":"Chemical"},{"id":"T130","span":{"begin":134,"end":149},"obj":"Chemical"},{"id":"T131","span":{"begin":151,"end":154},"obj":"Chemical"},{"id":"T134","span":{"begin":169,"end":174},"obj":"Chemical"},{"id":"T135","span":{"begin":191,"end":194},"obj":"Chemical"},{"id":"T136","span":{"begin":195,"end":202},"obj":"Chemical"},{"id":"T137","span":{"begin":228,"end":231},"obj":"Chemical"},{"id":"T138","span":{"begin":257,"end":260},"obj":"Chemical"},{"id":"T139","span":{"begin":273,"end":288},"obj":"Chemical"},{"id":"T140","span":{"begin":290,"end":293},"obj":"Chemical"},{"id":"T141","span":{"begin":308,"end":310},"obj":"Chemical"},{"id":"T142","span":{"begin":312,"end":317},"obj":"Chemical"},{"id":"T143","span":{"begin":323,"end":325},"obj":"Chemical"},{"id":"T144","span":{"begin":327,"end":330},"obj":"Chemical"},{"id":"T147","span":{"begin":356,"end":363},"obj":"Chemical"},{"id":"T148","span":{"begin":396,"end":399},"obj":"Chemical"}],"attributes":[{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_60949"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_32145"},{"id":"A126","pred":"chebi_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/CHEBI_17790"},{"id":"A127","pred":"chebi_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/CHEBI_35026"},{"id":"A128","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_28621"},{"id":"A129","pred":"chebi_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/CHEBI_35026"},{"id":"A130","pred":"chebi_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/CHEBI_26911"},{"id":"A131","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_15635"},{"id":"A132","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_20506"},{"id":"A133","pred":"chebi_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/CHEBI_26911"},{"id":"A134","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_25698"},{"id":"A135","pred":"chebi_id","subj":"T135","obj":"http://purl.obolibrary.org/obo/CHEBI_17883"},{"id":"A136","pred":"chebi_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/CHEBI_46923"},{"id":"A137","pred":"chebi_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/CHEBI_47266"},{"id":"A138","pred":"chebi_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/CHEBI_27789"},{"id":"A139","pred":"chebi_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/CHEBI_15767"},{"id":"A140","pred":"chebi_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/CHEBI_15767"},{"id":"A141","pred":"chebi_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/CHEBI_25107"},{"id":"A142","pred":"chebi_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/CHEBI_31823"},{"id":"A143","pred":"chebi_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/CHEBI_23116"},{"id":"A144","pred":"chebi_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/CHEBI_15635"},{"id":"A145","pred":"chebi_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/CHEBI_20506"},{"id":"A146","pred":"chebi_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/CHEBI_26911"},{"id":"A147","pred":"chebi_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/CHEBI_30145"},{"id":"A148","pred":"chebi_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/CHEBI_15635"},{"id":"A149","pred":"chebi_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/CHEBI_20506"},{"id":"A150","pred":"chebi_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/CHEBI_26911"}],"text":"Scheme 1 Preparation of P1 Synthetic Intermediates\n(i) 3 M NaOH, MeOH (95%), (ii) isobutylchloroformate (IBCF), triethylamine (TEA), tetrahydrofuran (THF), (iii) CH2N2/ether (92%), (iv) 4 M HCl/dioxane (83%), (v) 1.0 equiv 48% HBr (83%), (vi) HNCH3(OCH3), EDC, HOBt, NMM, dichloromethane (DCM) (79%), (vii) Mg, HgCl2, BOM-Cl, THF, −78°C (50%), and (viii) lithium diisopropylamide (LDA), ClCH2I, THF (54%)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T53","span":{"begin":0,"end":51},"obj":"Sentence"},{"id":"T54","span":{"begin":52,"end":406},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Scheme 1 Preparation of P1 Synthetic Intermediates\n(i) 3 M NaOH, MeOH (95%), (ii) isobutylchloroformate (IBCF), triethylamine (TEA), tetrahydrofuran (THF), (iii) CH2N2/ether (92%), (iv) 4 M HCl/dioxane (83%), (v) 1.0 equiv 48% HBr (83%), (vi) HNCH3(OCH3), EDC, HOBt, NMM, dichloromethane (DCM) (79%), (vii) Mg, HgCl2, BOM-Cl, THF, −78°C (50%), and (viii) lithium diisopropylamide (LDA), ClCH2I, THF (54%)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T5","span":{"begin":290,"end":293},"obj":"Phenotype"}],"attributes":[{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0001644"}],"text":"Scheme 1 Preparation of P1 Synthetic Intermediates\n(i) 3 M NaOH, MeOH (95%), (ii) isobutylchloroformate (IBCF), triethylamine (TEA), tetrahydrofuran (THF), (iii) CH2N2/ether (92%), (iv) 4 M HCl/dioxane (83%), (v) 1.0 equiv 48% HBr (83%), (vi) HNCH3(OCH3), EDC, HOBt, NMM, dichloromethane (DCM) (79%), (vii) Mg, HgCl2, BOM-Cl, THF, −78°C (50%), and (viii) lithium diisopropylamide (LDA), ClCH2I, THF (54%)."}