PMC:7571312 / 105282-106424 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T30 411-412 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 567-568 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 930-932 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T33 967-972 http://purl.obolibrary.org/obo/CLO_0007706 denotes M + H

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T18482 77-83 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T3913 86-89 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T17528 120-126 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T46489 127-133 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T9807 134-139 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T48158 140-148 Chemical denotes carbonyl http://purl.obolibrary.org/obo/CHEBI_23019
T69723 150-163 Chemical denotes 3-methylbutyl http://purl.obolibrary.org/obo/CHEBI_30359
T81751 167-174 Chemical denotes methoxy http://purl.obolibrary.org/obo/CHEBI_32772|http://purl.obolibrary.org/obo/CHEBI_44520
T16849 175-184 Chemical denotes 1H-indole http://purl.obolibrary.org/obo/CHEBI_16881
T59070 175-177 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T70034 178-184 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_35581
T51068 187-198 Chemical denotes carboxamide http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622
T34589 216-218 Chemical denotes N2 http://purl.obolibrary.org/obo/CHEBI_17997
T45671 220-239 Chemical denotes tert-butoxycarbonyl http://purl.obolibrary.org/obo/CHEBI_48502
T53546 252-258 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T6792 261-264 Chemical denotes oxo http://purl.obolibrary.org/obo/CHEBI_46629
T23315 295-301 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T89825 302-308 Chemical denotes propyl http://purl.obolibrary.org/obo/CHEBI_26308
T80551 312-318 Chemical denotes methyl http://purl.obolibrary.org/obo/CHEBI_32875|http://purl.obolibrary.org/obo/CHEBI_29309
T63930 337-343 Chemical denotes indole http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581
T89213 346-361 Chemical denotes carboxylic acid http://purl.obolibrary.org/obo/CHEBI_33575
T96977 357-361 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T25472 498-506 Chemical denotes methanol http://purl.obolibrary.org/obo/CHEBI_17790
T84236 507-517 Chemical denotes chloroform http://purl.obolibrary.org/obo/CHEBI_35255
T28525 588-590 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T18910 596-600 Chemical denotes DMSO http://purl.obolibrary.org/obo/CHEBI_28262
T44223 617-619 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T52771 641-643 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T21993 665-667 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T14169 679-681 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T36677 703-705 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T66878 727-729 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T30164 741-743 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T69157 765-767 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T78349 789-791 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T72436 822-824 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T99712 850-852 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T36064 864-866 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T34105 878-880 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T89514 892-894 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T86892 930-932 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T30542 1010-1015 Chemical denotes CHCl3 http://purl.obolibrary.org/obo/CHEBI_35255

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T583 0-431 Sentence denotes Following the procedure described for the preparation of N-((1S)-1-{[((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)amino]carbonyl}-3-methylbutyl)-4-methoxy-1H-indole-2-carboxamide but substituting N2-(tert-butoxycarbonyl)-N1-((1S)-3-chloro-2-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}propyl)-4-methyl-l-leucinamide and indole-2-carboxylic acid and making no other critical variations provided a crude yellow foam.
T584 432-587 Sentence denotes This material was purified by Biotage MPLC (40 M column, 2.5–3.5% methanol/chloroform) to afford 1.06 g (62%) of the title compound as a light yellow foam.
T585 588-1045 Sentence denotes 1H NMR (DMSO-d6) δ 11.59 (s, 1H), 8.58 (d, J = 8 Hz, 1H), 8.50 (d, J = 8 Hz, 1H), 7.64 (s, 1H), 7.61 (d, J = 8 Hz, 1H), 7.41 (d, J = 8 Hz, 1H), 7.23 (s, 1H), 7.17 (t, J = 8 Hz, 1H), 7.02 (t, J = 8 Hz, 1H), 4.62–4.50 (m, 3H), 4.45 (m, 1H), 3.10 (m, 2H), 2.25 (m, 1H), 2.08 (m, 1H), 1.96 (m, 1H), 1.80 (m, 1H), 1.72–1.58 (m, 3H), 0.94 (s, 9H); MS (ESI+) for C24H31ClN4O4m/z 475.1 (M + H)+; anal. calcd for C24H31ClN4O4·0.35 CHCl3: C, 56.59; H, 6.12; N, 10.84.
T586 1046-1142 Sentence denotes Found: C, 56.38; H, 6.18; N, 10.75; HRMS (ESI+) calcd for C24H31ClN4O4 475.2107, found 475.2122.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1924 498-506 Chemical denotes methanol MESH:D000432
1925 507-517 Chemical denotes chloroform MESH:D002725
1926 992-1004 Chemical denotes C24H31ClN4O4
1927 1010-1015 Chemical denotes CHCl3
1928 1017-1018 Chemical denotes C MESH:D002244
1929 1036-1037 Chemical denotes N MESH:D009584
1930 1053-1054 Chemical denotes C MESH:D002244
1931 1072-1073 Chemical denotes N MESH:D009584
1932 1104-1116 Chemical denotes C24H31ClN4O4
1933 1082-1086 Disease denotes HRMS