PMC:7565665 / 8914-9298 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T47","span":{"begin":179,"end":194},"obj":"Body_part"},{"id":"T48","span":{"begin":196,"end":198},"obj":"Body_part"},{"id":"T49","span":{"begin":351,"end":355},"obj":"Body_part"}],"attributes":[{"id":"A47","pred":"fma_id","subj":"T47","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A48","pred":"fma_id","subj":"T48","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A49","pred":"fma_id","subj":"T49","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"CF is a genetic disorder, wherein the ΔF508-CFTR is the most common mutation leading to lack of membrane-resident functional CFTR, where the absence of the functional CFTR on the plasma membrane (PM) deteriorates the pathogen clearance ability in CF subjects, leading to persistent infections and chronic inflammation, culminating into a catastrophic lung function decline [51,52,53]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T16","span":{"begin":351,"end":355},"obj":"Body_part"}],"attributes":[{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"CF is a genetic disorder, wherein the ΔF508-CFTR is the most common mutation leading to lack of membrane-resident functional CFTR, where the absence of the functional CFTR on the plasma membrane (PM) deteriorates the pathogen clearance ability in CF subjects, leading to persistent infections and chronic inflammation, culminating into a catastrophic lung function decline [51,52,53]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T89","span":{"begin":0,"end":2},"obj":"Disease"},{"id":"T90","span":{"begin":8,"end":24},"obj":"Disease"},{"id":"T91","span":{"begin":247,"end":249},"obj":"Disease"},{"id":"T92","span":{"begin":282,"end":292},"obj":"Disease"},{"id":"T93","span":{"begin":305,"end":317},"obj":"Disease"}],"attributes":[{"id":"A89","pred":"mondo_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"},{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0003847"},{"id":"A91","pred":"mondo_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/MONDO_0009061"},{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"CF is a genetic disorder, wherein the ΔF508-CFTR is the most common mutation leading to lack of membrane-resident functional CFTR, where the absence of the functional CFTR on the plasma membrane (PM) deteriorates the pathogen clearance ability in CF subjects, leading to persistent infections and chronic inflammation, culminating into a catastrophic lung function decline [51,52,53]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T76","span":{"begin":6,"end":7},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T77","span":{"begin":44,"end":48},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T78","span":{"begin":96,"end":104},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T79","span":{"begin":125,"end":129},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T80","span":{"begin":167,"end":171},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T81","span":{"begin":179,"end":185},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"T82","span":{"begin":186,"end":194},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T83","span":{"begin":336,"end":337},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T84","span":{"begin":351,"end":355},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T85","span":{"begin":351,"end":355},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"text":"CF is a genetic disorder, wherein the ΔF508-CFTR is the most common mutation leading to lack of membrane-resident functional CFTR, where the absence of the functional CFTR on the plasma membrane (PM) deteriorates the pathogen clearance ability in CF subjects, leading to persistent infections and chronic inflammation, culminating into a catastrophic lung function decline [51,52,53]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T27","span":{"begin":196,"end":198},"obj":"Chemical"}],"attributes":[{"id":"A27","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_141444"},{"id":"A28","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_16410"},{"id":"A29","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_53551"}],"text":"CF is a genetic disorder, wherein the ΔF508-CFTR is the most common mutation leading to lack of membrane-resident functional CFTR, where the absence of the functional CFTR on the plasma membrane (PM) deteriorates the pathogen clearance ability in CF subjects, leading to persistent infections and chronic inflammation, culminating into a catastrophic lung function decline [51,52,53]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"217","span":{"begin":44,"end":48},"obj":"Gene"},{"id":"218","span":{"begin":125,"end":129},"obj":"Gene"},{"id":"219","span":{"begin":167,"end":171},"obj":"Gene"},{"id":"233","span":{"begin":8,"end":24},"obj":"Disease"},{"id":"234","span":{"begin":282,"end":292},"obj":"Disease"},{"id":"235","span":{"begin":305,"end":317},"obj":"Disease"}],"attributes":[{"id":"A217","pred":"tao:has_database_id","subj":"217","obj":"Gene:1080"},{"id":"A218","pred":"tao:has_database_id","subj":"218","obj":"Gene:1080"},{"id":"A219","pred":"tao:has_database_id","subj":"219","obj":"Gene:1080"},{"id":"A233","pred":"tao:has_database_id","subj":"233","obj":"MESH:D030342"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"MESH:D007239"},{"id":"A235","pred":"tao:has_database_id","subj":"235","obj":"MESH:D007249"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"CF is a genetic disorder, wherein the ΔF508-CFTR is the most common mutation leading to lack of membrane-resident functional CFTR, where the absence of the functional CFTR on the plasma membrane (PM) deteriorates the pathogen clearance ability in CF subjects, leading to persistent infections and chronic inflammation, culminating into a catastrophic lung function decline [51,52,53]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T100","span":{"begin":44,"end":48},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T101","span":{"begin":125,"end":129},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T102","span":{"begin":167,"end":171},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T103","span":{"begin":305,"end":317},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"CF is a genetic disorder, wherein the ΔF508-CFTR is the most common mutation leading to lack of membrane-resident functional CFTR, where the absence of the functional CFTR on the plasma membrane (PM) deteriorates the pathogen clearance ability in CF subjects, leading to persistent infections and chronic inflammation, culminating into a catastrophic lung function decline [51,52,53]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T42","span":{"begin":0,"end":384},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"CF is a genetic disorder, wherein the ΔF508-CFTR is the most common mutation leading to lack of membrane-resident functional CFTR, where the absence of the functional CFTR on the plasma membrane (PM) deteriorates the pathogen clearance ability in CF subjects, leading to persistent infections and chronic inflammation, culminating into a catastrophic lung function decline [51,52,53]."}