PMC:7565665 / 77660-79263 JSONTXT

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T522","span":{"begin":213,"end":233},"obj":"Disease"},{"id":"T523","span":{"begin":592,"end":612},"obj":"Disease"},{"id":"T524","span":{"begin":622,"end":638},"obj":"Disease"},{"id":"T525","span":{"begin":1088,"end":1098},"obj":"Disease"},{"id":"T526","span":{"begin":1233,"end":1253},"obj":"Disease"}],"attributes":[{"id":"A522","pred":"mondo_id","subj":"T522","obj":"http://purl.obolibrary.org/obo/MONDO_0005087"},{"id":"A523","pred":"mondo_id","subj":"T523","obj":"http://purl.obolibrary.org/obo/MONDO_0005113"},{"id":"A524","pred":"mondo_id","subj":"T524","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A525","pred":"mondo_id","subj":"T525","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A526","pred":"mondo_id","subj":"T526","obj":"http://purl.obolibrary.org/obo/MONDO_0005087"}],"text":"Therefore, targeting and inducing the autophagy pathway is an area of tremendous clinical significance. Autophagy-inducing drugs may be necessary for overcoming the CFTR-autophagy impairment found in many chronic respiratory diseases to prevent exacerbations and improve the morbidity and mortality for patients while cutting health care costs for these individuals. Moreover, autophagy-inducing drugs offer the ability to fight pathogens without causing MDR bacteria and the need to develop strain specific antivirals. As a result, an autophagy induction intervention strategy to handle MDR bacterial infections or novel viral infections provides significant benefits in terms of controlling exacerbations, whereas autophagy induction with drugs currently approved for other conditions allows rapid translation. Moreover, the proposed autophagy augmenting therapeutic strategy also provides a possible treatment in situations where it is not possible to develop an antiviral for a pathogen. Furthermore, autophagy induction also can offer an effective way to treat current recurring MDR infections. Hence, future clinical studies need to expand their scope beyond the horizon of antibiotics and antivirals for the treatment of many respiratory diseases and begin investigating the therapeutic benefits that autophagy augmenting drugs may have in a myriad of clinical situations. In doing so, we can achieve a significant reduction in the overwhelming health care costs and resources needed for respiratory exacerbations while improving the quality of life with a reduction in the mortality of patients."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T876","span":{"begin":165,"end":169},"obj":"http://purl.obolibrary.org/obo/PR_000001044"},{"id":"T877","span":{"begin":459,"end":467},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2"},{"id":"T878","span":{"begin":523,"end":524},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T879","span":{"begin":892,"end":893},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T880","span":{"begin":980,"end":981},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T881","span":{"begin":1347,"end":1348},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T882","span":{"begin":1408,"end":1409},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T883","span":{"begin":1562,"end":1563},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Therefore, targeting and inducing the autophagy pathway is an area of tremendous clinical significance. Autophagy-inducing drugs may be necessary for overcoming the CFTR-autophagy impairment found in many chronic respiratory diseases to prevent exacerbations and improve the morbidity and mortality for patients while cutting health care costs for these individuals. Moreover, autophagy-inducing drugs offer the ability to fight pathogens without causing MDR bacteria and the need to develop strain specific antivirals. As a result, an autophagy induction intervention strategy to handle MDR bacterial infections or novel viral infections provides significant benefits in terms of controlling exacerbations, whereas autophagy induction with drugs currently approved for other conditions allows rapid translation. Moreover, the proposed autophagy augmenting therapeutic strategy also provides a possible treatment in situations where it is not possible to develop an antiviral for a pathogen. Furthermore, autophagy induction also can offer an effective way to treat current recurring MDR infections. Hence, future clinical studies need to expand their scope beyond the horizon of antibiotics and antivirals for the treatment of many respiratory diseases and begin investigating the therapeutic benefits that autophagy augmenting drugs may have in a myriad of clinical situations. In doing so, we can achieve a significant reduction in the overwhelming health care costs and resources needed for respiratory exacerbations while improving the quality of life with a reduction in the mortality of patients."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T235","span":{"begin":123,"end":128},"obj":"Chemical"},{"id":"T11038","span":{"begin":396,"end":401},"obj":"Chemical"},{"id":"T237","span":{"begin":455,"end":458},"obj":"Chemical"},{"id":"T238","span":{"begin":508,"end":518},"obj":"Chemical"},{"id":"T75877","span":{"begin":588,"end":591},"obj":"Chemical"},{"id":"T20047","span":{"begin":741,"end":746},"obj":"Chemical"},{"id":"T57792","span":{"begin":966,"end":975},"obj":"Chemical"},{"id":"T52731","span":{"begin":1084,"end":1087},"obj":"Chemical"},{"id":"T40974","span":{"begin":1180,"end":1191},"obj":"Chemical"},{"id":"T81365","span":{"begin":1196,"end":1206},"obj":"Chemical"},{"id":"T4284","span":{"begin":1329,"end":1334},"obj":"Chemical"}],"attributes":[{"id":"A75108","pred":"chebi_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A22014","pred":"chebi_id","subj":"T11038","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A15459","pred":"chebi_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/CHEBI_53218"},{"id":"A11154","pred":"chebi_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A70374","pred":"chebi_id","subj":"T75877","obj":"http://purl.obolibrary.org/obo/CHEBI_53218"},{"id":"A83335","pred":"chebi_id","subj":"T20047","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A71505","pred":"chebi_id","subj":"T57792","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A92140","pred":"chebi_id","subj":"T52731","obj":"http://purl.obolibrary.org/obo/CHEBI_53218"},{"id":"A40668","pred":"chebi_id","subj":"T40974","obj":"http://purl.obolibrary.org/obo/CHEBI_33281"},{"id":"A97827","pred":"chebi_id","subj":"T81365","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A43984","pred":"chebi_id","subj":"T4284","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Therefore, targeting and inducing the autophagy pathway is an area of tremendous clinical significance. Autophagy-inducing drugs may be necessary for overcoming the CFTR-autophagy impairment found in many chronic respiratory diseases to prevent exacerbations and improve the morbidity and mortality for patients while cutting health care costs for these individuals. Moreover, autophagy-inducing drugs offer the ability to fight pathogens without causing MDR bacteria and the need to develop strain specific antivirals. As a result, an autophagy induction intervention strategy to handle MDR bacterial infections or novel viral infections provides significant benefits in terms of controlling exacerbations, whereas autophagy induction with drugs currently approved for other conditions allows rapid translation. Moreover, the proposed autophagy augmenting therapeutic strategy also provides a possible treatment in situations where it is not possible to develop an antiviral for a pathogen. Furthermore, autophagy induction also can offer an effective way to treat current recurring MDR infections. Hence, future clinical studies need to expand their scope beyond the horizon of antibiotics and antivirals for the treatment of many respiratory diseases and begin investigating the therapeutic benefits that autophagy augmenting drugs may have in a myriad of clinical situations. In doing so, we can achieve a significant reduction in the overwhelming health care costs and resources needed for respiratory exacerbations while improving the quality of life with a reduction in the mortality of patients."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1879","span":{"begin":165,"end":169},"obj":"Gene"},{"id":"1880","span":{"begin":303,"end":311},"obj":"Species"},{"id":"1881","span":{"begin":1594,"end":1602},"obj":"Species"},{"id":"1882","span":{"begin":1495,"end":1506},"obj":"Species"},{"id":"1883","span":{"begin":213,"end":233},"obj":"Disease"},{"id":"1884","span":{"begin":289,"end":298},"obj":"Disease"},{"id":"1885","span":{"begin":592,"end":612},"obj":"Disease"},{"id":"1886","span":{"begin":622,"end":638},"obj":"Disease"},{"id":"1887","span":{"begin":1088,"end":1098},"obj":"Disease"},{"id":"1888","span":{"begin":1233,"end":1253},"obj":"Disease"},{"id":"1889","span":{"begin":1581,"end":1590},"obj":"Disease"}],"attributes":[{"id":"A1879","pred":"tao:has_database_id","subj":"1879","obj":"Gene:1080"},{"id":"A1880","pred":"tao:has_database_id","subj":"1880","obj":"Tax:9606"},{"id":"A1881","pred":"tao:has_database_id","subj":"1881","obj":"Tax:9606"},{"id":"A1882","pred":"tao:has_database_id","subj":"1882","obj":"Tax:12814"},{"id":"A1883","pred":"tao:has_database_id","subj":"1883","obj":"MESH:D012140"},{"id":"A1884","pred":"tao:has_database_id","subj":"1884","obj":"MESH:D003643"},{"id":"A1885","pred":"tao:has_database_id","subj":"1885","obj":"MESH:D001424"},{"id":"A1886","pred":"tao:has_database_id","subj":"1886","obj":"MESH:D001102"},{"id":"A1887","pred":"tao:has_database_id","subj":"1887","obj":"MESH:D007239"},{"id":"A1888","pred":"tao:has_database_id","subj":"1888","obj":"MESH:D012140"},{"id":"A1889","pred":"tao:has_database_id","subj":"1889","obj":"MESH:D003643"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Therefore, targeting and inducing the autophagy pathway is an area of tremendous clinical significance. Autophagy-inducing drugs may be necessary for overcoming the CFTR-autophagy impairment found in many chronic respiratory diseases to prevent exacerbations and improve the morbidity and mortality for patients while cutting health care costs for these individuals. Moreover, autophagy-inducing drugs offer the ability to fight pathogens without causing MDR bacteria and the need to develop strain specific antivirals. As a result, an autophagy induction intervention strategy to handle MDR bacterial infections or novel viral infections provides significant benefits in terms of controlling exacerbations, whereas autophagy induction with drugs currently approved for other conditions allows rapid translation. Moreover, the proposed autophagy augmenting therapeutic strategy also provides a possible treatment in situations where it is not possible to develop an antiviral for a pathogen. Furthermore, autophagy induction also can offer an effective way to treat current recurring MDR infections. Hence, future clinical studies need to expand their scope beyond the horizon of antibiotics and antivirals for the treatment of many respiratory diseases and begin investigating the therapeutic benefits that autophagy augmenting drugs may have in a myriad of clinical situations. In doing so, we can achieve a significant reduction in the overwhelming health care costs and resources needed for respiratory exacerbations while improving the quality of life with a reduction in the mortality of patients."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T984","span":{"begin":38,"end":47},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T985","span":{"begin":38,"end":47},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T986","span":{"begin":104,"end":113},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T987","span":{"begin":104,"end":113},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T988","span":{"begin":165,"end":169},"obj":"http://purl.obolibrary.org/obo/GO_0005260"},{"id":"T989","span":{"begin":170,"end":179},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T990","span":{"begin":170,"end":179},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T991","span":{"begin":377,"end":386},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T992","span":{"begin":377,"end":386},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T993","span":{"begin":536,"end":545},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T994","span":{"begin":536,"end":545},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T995","span":{"begin":622,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0016032"},{"id":"T996","span":{"begin":716,"end":725},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T997","span":{"begin":716,"end":725},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T998","span":{"begin":800,"end":811},"obj":"http://purl.obolibrary.org/obo/GO_0006412"},{"id":"T999","span":{"begin":836,"end":845},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T1000","span":{"begin":836,"end":845},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T1001","span":{"begin":1005,"end":1014},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T1002","span":{"begin":1005,"end":1014},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T1003","span":{"begin":1308,"end":1317},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T1004","span":{"begin":1308,"end":1317},"obj":"http://purl.obolibrary.org/obo/GO_0006914"}],"text":"Therefore, targeting and inducing the autophagy pathway is an area of tremendous clinical significance. Autophagy-inducing drugs may be necessary for overcoming the CFTR-autophagy impairment found in many chronic respiratory diseases to prevent exacerbations and improve the morbidity and mortality for patients while cutting health care costs for these individuals. Moreover, autophagy-inducing drugs offer the ability to fight pathogens without causing MDR bacteria and the need to develop strain specific antivirals. As a result, an autophagy induction intervention strategy to handle MDR bacterial infections or novel viral infections provides significant benefits in terms of controlling exacerbations, whereas autophagy induction with drugs currently approved for other conditions allows rapid translation. Moreover, the proposed autophagy augmenting therapeutic strategy also provides a possible treatment in situations where it is not possible to develop an antiviral for a pathogen. Furthermore, autophagy induction also can offer an effective way to treat current recurring MDR infections. Hence, future clinical studies need to expand their scope beyond the horizon of antibiotics and antivirals for the treatment of many respiratory diseases and begin investigating the therapeutic benefits that autophagy augmenting drugs may have in a myriad of clinical situations. In doing so, we can achieve a significant reduction in the overwhelming health care costs and resources needed for respiratory exacerbations while improving the quality of life with a reduction in the mortality of patients."}

{"project":"LitCovid-sentences","denotations":[{"id":"T412","span":{"begin":0,"end":103},"obj":"Sentence"},{"id":"T413","span":{"begin":104,"end":366},"obj":"Sentence"},{"id":"T414","span":{"begin":367,"end":519},"obj":"Sentence"},{"id":"T415","span":{"begin":520,"end":812},"obj":"Sentence"},{"id":"T416","span":{"begin":813,"end":991},"obj":"Sentence"},{"id":"T417","span":{"begin":992,"end":1099},"obj":"Sentence"},{"id":"T418","span":{"begin":1100,"end":1379},"obj":"Sentence"},{"id":"T419","span":{"begin":1380,"end":1603},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Therefore, targeting and inducing the autophagy pathway is an area of tremendous clinical significance. Autophagy-inducing drugs may be necessary for overcoming the CFTR-autophagy impairment found in many chronic respiratory diseases to prevent exacerbations and improve the morbidity and mortality for patients while cutting health care costs for these individuals. Moreover, autophagy-inducing drugs offer the ability to fight pathogens without causing MDR bacteria and the need to develop strain specific antivirals. As a result, an autophagy induction intervention strategy to handle MDR bacterial infections or novel viral infections provides significant benefits in terms of controlling exacerbations, whereas autophagy induction with drugs currently approved for other conditions allows rapid translation. Moreover, the proposed autophagy augmenting therapeutic strategy also provides a possible treatment in situations where it is not possible to develop an antiviral for a pathogen. Furthermore, autophagy induction also can offer an effective way to treat current recurring MDR infections. Hence, future clinical studies need to expand their scope beyond the horizon of antibiotics and antivirals for the treatment of many respiratory diseases and begin investigating the therapeutic benefits that autophagy augmenting drugs may have in a myriad of clinical situations. In doing so, we can achieve a significant reduction in the overwhelming health care costs and resources needed for respiratory exacerbations while improving the quality of life with a reduction in the mortality of patients."}