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PMC:7565665 / 70183-71436 JSONTXT

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LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T496 810-820 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T497 1031-1041 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T806 54-58 http://purl.obolibrary.org/obo/PR_000001044 denotes CFTR
T807 713-721 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T808 750-751 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T809 955-963 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T810 1222-1230 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T15814 177-188 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T63851 332-334 Chemical denotes IV http://purl.obolibrary.org/obo/CHEBI_74327
T174 336-347 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T66577 531-533 Chemical denotes IV http://purl.obolibrary.org/obo/CHEBI_74327
T99338 534-545 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T70909 628-639 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T83059 733-736 Chemical denotes MDR http://purl.obolibrary.org/obo/CHEBI_53218
T72009 932-935 Chemical denotes MDR http://purl.obolibrary.org/obo/CHEBI_53218
T3847 976-979 Chemical denotes MDR http://purl.obolibrary.org/obo/CHEBI_53218
T45661 995-1006 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T7261 1062-1073 Chemical denotes antibiotics http://purl.obolibrary.org/obo/CHEBI_33281
T16389 1218-1221 Chemical denotes MDR http://purl.obolibrary.org/obo/CHEBI_53218

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1734 54-58 Gene denotes CFTR Gene:1080
1735 230-238 Species denotes patients Tax:9606
1736 591-599 Species denotes patients Tax:9606
1737 656-663 Species denotes patient Tax:9606
1738 671-678 Species denotes patient Tax:9606
1739 774-782 Species denotes patients Tax:9606
1740 810-820 Disease denotes infections MESH:D007239
1741 1031-1041 Disease denotes infections MESH:D007239

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T927 54-58 http://purl.obolibrary.org/obo/GO_0005260 denotes CFTR
T928 59-68 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T929 59-68 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T930 1183-1192 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T931 1183-1192 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T367 0-209 Sentence denotes Another reason to explore treatments that restore the CFTR-autophagy function to treat exacerbations is that the current first-line treatment for exacerbations usually includes antibiotics [4,173,210,212,213].
T368 210-363 Sentence denotes In situations where patients experience severe exacerbations, they are often hospitalized and given powerful intravenous (IV) antibiotics [4,31,173,176].
T369 364-457 Sentence denotes This is part of what plays into the exorbitant costs associated with recurrent exacerbations.
T370 458-606 Sentence denotes When looking specifically at exacerbations requiring hospitalization and IV-antibiotics, the cost is USD 36,319 per exacerbation for patients [176].
T371 607-858 Sentence denotes This frequent use of antibiotics in both the out-patient and in-patient treatment of exacerbations causes bacteria to develop MDR, which poses a significant issue for patients as the treatment of future infections becomes more difficult [151,214,215].
T372 859-946 Sentence denotes In fact, many pathogens that cause exacerbations have been found to have MDR [214,215].
T373 947-1105 Sentence denotes As more bacteria demonstrate MDR, more powerful antibiotics are needed to fight off infections, but these powerful antibiotics can have negative side effects.
T374 1106-1253 Sentence denotes As such, researchers have begun investigating the potential of targeting the autophagy pathway to fight off the MDR bacteria causing exacerbations.